Extracellular vesicles: a rising star for therapeutics and drug delivery

Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including t...

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Veröffentlicht in:Journal of nanobiotechnology Jg. 21; H. 1; S. 231 - 51
Hauptverfasser: Du, Shuang, Guan, Yucheng, Xie, Aihua, Yan, Zhao, Gao, Sijia, Li, Weirong, Rao, Lang, Chen, Xiaojia, Chen, Tongkai
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 20.07.2023
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Advanced local therapies from nano-engineered implants and biomaterials
Biomedical materials
Biopsy
Biosynthesis
Biotechnology
Cell organelles
Cells
Chemical properties
Chemistry
Chemistry and Materials Science
Clinical challenges
Drug delivery
Drug delivery systems
Drug loading
Drugs
Extracellular vesicles
Health aspects
Kinases
Lipids
Molecular Medicine
Molecular targeted therapy
Nanotechnology
Neurodegenerative diseases
Pharmaceutical research
Pharmacology
Physiology
Plasma
Proteins
Review
Surface modification
Targeted therapy
Vehicles
Vesicles
China
Extracellular vesicles
Surface modification
Drug loading
Neurodegenerative diseases
Targeted therapy
Clinical challenges
ISSN:1477-3155, 1477-3155
Online-Zugang:Volltext
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Abstract Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood – brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs. Graphical Abstract Highlights Various current techniques for isolating extracellular vesicles are reviewed, and their advantages and disadvantages are compared. An overview of the strategies used for the modification of extracellular vesicles and their application as delivery systems or therapeutic agents in different diseases is provided. Several challenges in the clinical application of extracellular vesicles-based nanoplatforms are discussed, along with solutions for their implementation as a promising therapeutic tool.
AbstractList Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood-brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs. Graphical Keywords: Extracellular vesicles, Drug loading, Surface modification, Targeted therapy, Neurodegenerative diseases, Clinical challenges
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood–brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs. Various current techniques for isolating extracellular vesicles are reviewed, and their advantages and disadvantages are compared.An overview of the strategies used for the modification of extracellular vesicles and their application as delivery systems or therapeutic agents in different diseases is provided.Several challenges in the clinical application of extracellular vesicles-based nanoplatforms are discussed, along with solutions for their implementation as a promising therapeutic tool.
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood – brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs. Graphical Abstract
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood-brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs.Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood-brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs.
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood – brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs. Graphical Abstract Highlights Various current techniques for isolating extracellular vesicles are reviewed, and their advantages and disadvantages are compared. An overview of the strategies used for the modification of extracellular vesicles and their application as delivery systems or therapeutic agents in different diseases is provided. Several challenges in the clinical application of extracellular vesicles-based nanoplatforms are discussed, along with solutions for their implementation as a promising therapeutic tool.
*Various current techniques for isolating extracellular vesicles are reviewed, and their advantages and disadvantages are compared.*An overview of the strategies used for the modification of extracellular vesicles and their application as delivery systems or therapeutic agents in different diseases is provided.*Several challenges in the clinical application of extracellular vesicles-based nanoplatforms are discussed, along with solutions for their implementation as a promising therapeutic tool.
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood-brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs.
Abstract Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood–brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs. Graphical Abstract
ArticleNumber 231
Audience Academic
Author Li, Weirong
Chen, Xiaojia
Guan, Yucheng
Chen, Tongkai
Du, Shuang
Yan, Zhao
Gao, Sijia
Xie, Aihua
Rao, Lang
Author_xml – sequence: 1
  givenname: Shuang
  surname: Du
  fullname: Du, Shuang
  organization: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine
– sequence: 2
  givenname: Yucheng
  surname: Guan
  fullname: Guan, Yucheng
  organization: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine
– sequence: 3
  givenname: Aihua
  surname: Xie
  fullname: Xie, Aihua
  organization: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine
– sequence: 4
  givenname: Zhao
  surname: Yan
  fullname: Yan, Zhao
  organization: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine
– sequence: 5
  givenname: Sijia
  surname: Gao
  fullname: Gao, Sijia
  organization: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
– sequence: 6
  givenname: Weirong
  surname: Li
  fullname: Li, Weirong
  organization: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine
– sequence: 7
  givenname: Lang
  surname: Rao
  fullname: Rao, Lang
  email: lrao@szbl.ac.cn
  organization: Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory
– sequence: 8
  givenname: Xiaojia
  surname: Chen
  fullname: Chen, Xiaojia
  email: xiaojiachen@um.edu.mo
  organization: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
– sequence: 9
  givenname: Tongkai
  surname: Chen
  fullname: Chen, Tongkai
  email: chentongkai@gzucm.edu.cn
  organization: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37475025$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Extracellular vesicles
Surface modification
Drug loading
Neurodegenerative diseases
Targeted therapy
Clinical challenges
Language English
License 2023. The Author(s).
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Snippet Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells....
*Various current techniques for isolating extracellular vesicles are reviewed, and their advantages and disadvantages are compared.*An overview of the...
Abstract Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source...
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SubjectTerms Advanced local therapies from nano-engineered implants and biomaterials
Biomedical materials
Biopsy
Biosynthesis
Biotechnology
Cell organelles
Cells
Chemical properties
Chemistry
Chemistry and Materials Science
Clinical challenges
Drug delivery
Drug delivery systems
Drug loading
Drugs
Extracellular vesicles
Health aspects
Kinases
Lipids
Molecular Medicine
Molecular targeted therapy
Nanotechnology
Neurodegenerative diseases
Pharmaceutical research
Pharmacology
Physiology
Plasma
Proteins
Review
Surface modification
Targeted therapy
Vehicles
Vesicles
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Title Extracellular vesicles: a rising star for therapeutics and drug delivery
URI https://link.springer.com/article/10.1186/s12951-023-01973-5
https://www.ncbi.nlm.nih.gov/pubmed/37475025
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