Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A

Bisphenol A (BPA) is an estrogenic endocrine disruptor commonly used in manufacture of polycarbonate plastics and epoxy resins. Due to its ubiquitous presence in the environment, health concerns are increasing. Earlier studies from our group have shown that neonatal exposure of male rats to BPA affe...

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Veröffentlicht in:	Toxicology (Amsterdam) Jg. 289; H. 2; S. 74 - 82
Hauptverfasser:	Doshi, Tanvi, Mehta, Smita Salian, Dighe, Vikas, Balasinor, Nafisa, Vanage, Geeta
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Kidlington Elsevier Ireland Ltd 18.11.2011 Elsevier
Schlagworte:	adulthood adults adverse effects Age Factors Animals Animals, Newborn Benzhydryl Compounds Biological and medical sciences Bisphenol A DNA DNA methylation DNA Methylation - drug effects DNA Methylation - physiology Emergency epigenetics epoxides Estrogen receptor Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism estrogen receptors Estrogens, Non-Steroidal - administration & dosage Female gene expression Male manufacturing Medical sciences methyltransferases Neonatal exposure Phenols - administration & dosage plastics Pregnancy promoter regions Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - physiology Rats Rats, Sprague-Dawley Receptors, Estrogen - biosynthesis Receptors, Estrogen - genetics resins reverse transcriptase polymerase chain reaction sesame oil spermatogenesis testes Testis - drug effects Testis - metabolism Toxicology Western blotting DNA methylation Bisphenol A Estrogen receptor Neonatal exposure Neonatal Rat Rodentia Endocrine disruptor Exposure Testicle Male genital system Promoter Vertebrata Mammalia DNA Adult animal Methylation Hormonal receptor
ISSN:	0300-483X, 1879-3185, 1879-3185
Online-Zugang:	Volltext
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