Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies

As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows minimal chances for developing resistance and has been recognized as a promising broad-spectrum antitumor drug becau...

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Bibliographic Details
Published in:	Journal of nanobiotechnology Vol. 21; no. 1; pp. 454 - 22
Main Authors:	Yu, Xiang, Jia, Siyu, Yu, Shi, Chen, Yaohui, Zhang, Chengwei, Chen, Haidan, Dai, Yanfeng
Format:	Journal Article
Language:	English
Published:	London BioMed Central 28.11.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Allergic reactions Angiogenesis Antimicrobial peptides Antimitotic agents Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Biotechnology Bladder cancer Cancer therapies Cell cycle Cell death Chemical properties Chemistry Chemistry and Materials Science Coagulation Colorectal cancer Cyclin-dependent kinases Cytolytic activity Dosage and administration Drug delivery Drug delivery systems Drug dosages Drug resistance Drugs Health aspects Humans Hypersensitivity Immunomodulation Immunomodulators Immunomodulatory Kinases Melitten - chemistry Melitten - pharmacology Melitten - therapeutic use Melittin Metastasis Molecular Medicine Molecular modelling Multimechanism Nanoparticles Nanoparticles - chemistry Nanotechnology Neoplasms - drug therapy Peptides Peptides - therapeutic use Pharmaceutical research Proteins Review Side effects Therapy Toxicity Tumor Tumor necrosis factor-TNF Tumors Vascular endothelial growth factor Vehicles China Tumor Side effects Melittin Immunomodulatory Multimechanism
ISSN:	1477-3155, 1477-3155
Online Access:	Get full text
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