Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies

As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows minimal chances for developing resistance and has been recognized as a promising broad-spectrum antitumor drug becau...

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Bibliographic Details
Published in:Journal of nanobiotechnology Vol. 21; no. 1; pp. 454 - 22
Main Authors: Yu, Xiang, Jia, Siyu, Yu, Shi, Chen, Yaohui, Zhang, Chengwei, Chen, Haidan, Dai, Yanfeng
Format: Journal Article
Language:English
Published: London BioMed Central 28.11.2023
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Allergic reactions
Angiogenesis
Antimicrobial peptides
Antimitotic agents
Antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antitumor activity
Apoptosis
Biotechnology
Bladder cancer
Cancer therapies
Cell cycle
Cell death
Chemical properties
Chemistry
Chemistry and Materials Science
Coagulation
Colorectal cancer
Cyclin-dependent kinases
Cytolytic activity
Dosage and administration
Drug delivery
Drug delivery systems
Drug dosages
Drug resistance
Drugs
Health aspects
Humans
Hypersensitivity
Immunomodulation
Immunomodulators
Immunomodulatory
Kinases
Melitten - chemistry
Melitten - pharmacology
Melitten - therapeutic use
Melittin
Metastasis
Molecular Medicine
Molecular modelling
Multimechanism
Nanoparticles
Nanoparticles - chemistry
Nanotechnology
Neoplasms - drug therapy
Peptides
Peptides - therapeutic use
Pharmaceutical research
Proteins
Review
Side effects
Therapy
Toxicity
Tumor
Tumor necrosis factor-TNF
Tumors
Vascular endothelial growth factor
Vehicles
China
Tumor
Side effects
Melittin
Immunomodulatory
Multimechanism
ISSN:1477-3155, 1477-3155
Online Access:Get full text
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Summary:As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows minimal chances for developing resistance and has been recognized as a promising broad-spectrum antitumor drug because of this unique dual mechanism of action. However, MLT still displays obvious toxic side effects during treatment, such as nonspecific cytolytic activity, hemolytic toxicity, coagulation disorders, and allergic reactions, seriously hampering its broad clinical applications. With thorough research on antitumor mechanisms and the rapid development of nanotechnology, significant effort has been devoted to shielding against toxicity and achieving tumor-directed drug delivery to improve the therapeutic efficacy of MLT. Herein, we mainly summarize the potential antitumor mechanisms of MLT and recent progress in the targeted delivery strategies for tumor therapy, such as passive targeting, active targeting and stimulus-responsive targeting. Additionally, we also highlight the prospects and challenges of realizing the full potential of MLT in the field of tumor therapy. By exploring the antitumor molecular mechanisms and delivery strategies of MLT, this comprehensive review may inspire new ideas for tumor multimechanism synergistic therapy.
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ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-023-02223-4