Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites . However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intr...

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Vydáno v:	Nature medicine Ročník 25; číslo 1; s. 89 - 94
Hlavní autoři:	Scheper, Wouter, Kelderman, Sander, Fanchi, Lorenzo F, Linnemann, Carsten, Bendle, Gavin, de Rooij, Marije A J, Hirt, Christian, Mezzadra, Riccardo, Slagter, Maarten, Dijkstra, Krijn, Kluin, Roelof J C, Snaebjornsson, Petur, Milne, Katy, Nelson, Brad H, Zijlmans, Henry, Kenter, Gemma, Voest, Emile E, Haanen, John B A G, Schumacher, Ton N
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Nature Publishing Group 01.01.2019
Témata:	CD8 antigen CD8-Positive T-Lymphocytes - immunology Colorectal cancer Colorectal carcinoma Humans Infiltration Jurkat Cells Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Metastases Neoplasms - immunology Neoplasms - pathology Ovarian cancer Phenotype Receptors, Antigen, T-Cell - metabolism Reproducibility of Results T cell receptors Tumors
ISSN:	1078-8956, 1546-170X, 1546-170X
On-line přístup:	Získat plný text
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