Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites . However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intr...

Ausführliche Beschreibung