Development of a hydrogel-based three-dimensional (3D) glioblastoma cell lines culture as a model system for CD73 inhibitor response study

Background Despite the development of various therapeutic approaches over the past decades, the treatment of glioblastoma multiforme (GBM) remains a major challenge. The extracellular adenosine-generating enzyme, CD73, is involved in the pathogenesis and progression of GBM, and targeting CD73 may re...

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Bibliographic Details
Published in:	Biomedical engineering online Vol. 23; no. 1; pp. 127 - 23
Main Authors:	Bahraminasab, Marjan, Asgharzade, Samira, Doostmohamadi, Ali, Satari, Atefeh, Hasannejad, Farkhonde, Arab, Samaneh
Format:	Journal Article
Language:	English
Published:	London BioMed Central 21.12.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	3D cell culture 5'-Nucleotidase - antagonists & inhibitors 5'-Nucleotidase - metabolism Adenosine Alginates - chemistry Alginates - pharmacology Alginic acid Angiogenesis Biocompatibility Biodegradation Biomaterials Biomedical Engineering and Bioengineering Biomedical Engineering/Biotechnology Biomedical materials Biotechnology Brain cancer Cancer Cancer therapies CD73 antigen CD73 inhibitor Cell culture Cell Culture Techniques, Three Dimensional Cell Line, Tumor Cell lines Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cell viability Colloids Confocal microscopy Drug therapy Engineering Enzyme inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fourier transforms Gelatin Gelatin–alginate hydrogel Glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Glioma GPI-Linked Proteins Health services Humans Hydrogels Hydrogels - chemistry Hydrogels - pharmacology Hypoxia Infrared analysis Infrared spectroscopy Inhibitors Medical prognosis Metastasis Microenvironments Microscopy Pathogenesis Patients Pharmaceuticals Polymers Real time Rheological properties Rheology Scanning electron microscopy Sodium Sodium alginate Spheroids Testing Tumor cells Tumor Microenvironment - drug effects Tumors Vascular endothelial growth factor Iran CD73 inhibitor 3D cell culture Glioblastoma Gelatin–alginate hydrogel
ISSN:	1475-925X, 1475-925X
Online Access:	Get full text
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