Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

Prostate cancer is an androgen-dependent disease subject to interactions between the tumor epithelium and its microenvironment. Here, we found that epigenetic changes in prostatic cancer-associated fibroblasts (CAF) initiated a cascade of stromal-epithelial interactions. This facilitated lethal pros...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 128; no. 10; pp. 4472 - 4484
Main Authors:	Mishra, Rajeev, Haldar, Subhash, Placencio, Veronica, Madhav, Anisha, Rohena-Rivera, Krizia, Agarwal, Priyanka, Duong, Frank, Angara, Bryan, Tripathi, Manisha, Liu, Zhenqiu, Gottlieb, Roberta A., Wagner, Shawn, Posadas, Edwin M., Bhowmick, Neil A.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.10.2018
Subjects:	Animals Care and treatment Diagnosis Fibroblasts - metabolism Fibroblasts - pathology Gene mutation Gene Silencing Genetic aspects Glutamine - genetics Glutamine - metabolism Health aspects Hormone therapy Humans Male Methods Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neuroendocrine Tumors - genetics Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology Patient outcomes Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - metabolism Epigenetics Metabolism Molecular biology Cancer Cell Biology
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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