Polyphyllin I alleviates neuroinflammation after cerebral ischemia–reperfusion injury via facilitating autophagy-mediated M2 microglial polarization

Microglial activation and polarization play a central role in poststroke inflammation and neuronal damage. Modulating microglial polarization from pro-inflammatory to anti-inflammatory phenotype is a promising therapeutic strategy for the treatment of cerebral ischemia. Polyphyllin I (PPI), a steroi...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Jg. 30; H. 1; S. 59 - 18
Hauptverfasser:	Kang, Chunyang, Sang, Qiuling, Liu, Dingxi, Wang, Libo, Li, Jia, Liu, Xiaoyang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 14.05.2024 Springer Nature B.V BMC
Schlagworte:	Animals Apoptosis Autophagy Autophagy - drug effects Biomedical and Life Sciences Biomedicine Brain Brain Ischemia - drug therapy Brain Ischemia - metabolism Cancer Carotid arteries Cell Polarity - drug effects Cerebral ischemia Cytokines Diosgenin - analogs & derivatives Diosgenin - pharmacology Diosgenin - therapeutic use Disease Models, Animal Infarction, Middle Cerebral Artery - drug therapy Inflammation Ischemia Male Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Microglial polarization Molecular Medicine Neuroinflammatory Diseases - drug therapy Neuroinflammatory Diseases - etiology Neuroinflammatory Diseases - metabolism NLRP3 inflammasome Polyphyllin I (PPI) Reperfusion Injury - drug therapy Reperfusion Injury - etiology Reperfusion Injury - metabolism Research Article Signal Transduction - drug effects Stroke Surgery Tissues TOR Serine-Threonine Kinases - metabolism Veins & arteries United States > US China Japan Cerebral ischemia NLRP3 inflammasome Microglial polarization Polyphyllin I (PPI) Autophagy
ISSN:	1528-3658, 1076-1551, 1528-3658
Online-Zugang:	Volltext
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