Targeting senescent cells enhances adipogenesis and metabolic function in old age

Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhibit adipogenesis in non-senescent progenitors. Blo...

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Vydáno v:	eLife Ročník 4; s. e12997
Hlavní autoři:	Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England eLife Science Publications, Ltd 19.12.2015 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Témata:	Activin A Activins - secretion Adipogenesis Adipose tissues adipose-derived stem cells Animals Cell differentiation Cellular Senescence Developmental Biology and Stem Cells Human Biology and Medicine Humans Inhibitor drugs INK-ATTAC insulin sensitivity JAK/STAT Mice Old age Physiological aspects Physiological research ruxolitinib Stem Cells - physiology human biology Activin A stem cells INK-ATTAC rat developmental biology medicine JAK/STAT adipose-derived stem cells insulin sensitivity mouse ruxolitinib human
ISSN:	2050-084X, 2050-084X
On-line přístup:	Získat plný text
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