Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo

The essential Smc5/6 complex is required in response to replication stress and is best known for ensuring the fidelity of homologous recombination. Using single-molecule tracking in live fission yeast to investigate Smc5/6 chromatin association, we show that Smc5/6 is chromatin associated in unchall...

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Veröffentlicht in:	eLife Jg. 10
Hauptverfasser:	Etheridge, Thomas J, Villahermosa, Desiree, Campillo-Funollet, Eduard, Herbert, Alex David, Irmisch, Anja, Watson, Adam T, Dang, Hung Q, Osborne, Mark A, Oliver, Antony W, Carr, Antony M, Murray, Johanne M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Science Publications, Ltd 16.04.2021 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Schlagworte:	Adenosine triphosphatase Cell Cycle Proteins - metabolism Chromatin Chromatin - metabolism Chromosome rearrangements Chromosomes and Gene Expression DNA damage DNA repair Experiments Genetics and Genomics Homologous recombination Lasers Localization Microscopy Proteins Replication Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - metabolism Single Molecule Imaging single-molecule microscopy Single-stranded DNA SMC proteins Yeast genetics S. pombe chromosomes SMC proteins genomics single-molecule microscopy DNA repair gene expression
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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