Generalized functional varying-index coefficient model for dynamic synergistic gene-environment interactions with binary longitudinal traits

The genetic basis of complex traits involves the function of many genes with small effects as well as complex gene-gene and gene-environment interactions. As one of the major players in complex diseases, the role of gene-environment interactions has been increasingly recognized. Motivated by epidemi...

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Bibliographic Details
Published in:	PloS one Vol. 20; no. 1; p. e0318103
Main Authors:	Zhang, Jingyi, Wang, Honglang, Cui, Yuehua
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 27.01.2025 Public Library of Science (PLoS)
Subjects:	Approximation Biology and Life Sciences Blood pressure Computer Simulation Data analysis Disease Engineering and Technology Environmental effects Environmental factors Epidemiology Functionals Gene-Environment Interaction Genes Genetic effects Genetic research Genetic susceptibility Genotype-environment interactions Humans Hypotheses Hypothesis testing Longitudinal method Longitudinal Studies Medicine and Health Sciences Methods Mixtures Models, Genetic Monte Carlo Method Monte Carlo simulation Pain sensitivity Performance evaluation Physical sciences Pressure effects Research and analysis methods Sensitivity analysis Single-nucleotide polymorphism Spline functions Statistical models Variables United States
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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