Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis

We describe a method for correlating the immunoglobulin (Ig) proteomes with the B cell transcriptomes in human fluid and tissue samples, using multiple sclerosis as a paradigm. Oligoclonal Ig bands and elevated numbers of clonally expanded B cells in the cerebrospinal fluid (CSF) are diagnostic hall...

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Bibliographic Details
Published in:	Nature medicine Vol. 14; no. 6; pp. 688 - 693
Main Authors:	Obermeier, Birgit, Mentele, Reinhard, Malotka, Joachim, Kellermann, Josef, Kümpfel, Tania, Wekerle, Hartmut, Lottspeich, Friedrich, Hohlfeld, Reinhard, Dornmair, Klaus
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2008 Nature Publishing Group
Subjects:	Amino Acid Sequence B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Body fluids Cancer Research Care and treatment Cellular biology Cerebrospinal fluid Cerebrospinal Fluid Proteins - genetics Cerebrospinal Fluid Proteins - immunology Databases, Genetic Diagnosis Gels Health aspects Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Light Chains - genetics Immunoglobulin Variable Region - genetics Immunoglobulins Infectious Diseases Isoelectric Focusing Mass Spectrometry Medical research Metabolic Diseases Molecular Medicine Molecular Sequence Data Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - immunology Mutation Neurosciences Oligoclonal Bands - genetics Oligoclonal Bands - immunology Peptides Proteome - analysis Proteomics Research methodology Risk factors Sequence Homology, Amino Acid Spine technical-report Transcription, Genetic Germany
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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