Hybrids of RNA viruses and viroid-like elements replicate in fungi

Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase (RdRp), whereas viroid-like elements consist...

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Vydáno v:	Nature communications Ročník 14; číslo 1; s. 2591 - 11
Hlavní autoři:	Forgia, Marco, Navarro, Beatriz, Daghino, Stefania, Cervera, Amelia, Gisel, Andreas, Perotto, Silvia, Aghayeva, Dilzara N., Akinyuwa, Mary F., Gobbi, Emanuela, Zheludev, Ivan N., Edgar, Robert C., Chikhi, Rayan, Turina, Massimo, Babaian, Artem, Di Serio, Francesco, de la Peña, Marcos
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 05.05.2023 Nature Publishing Group Nature Portfolio
Témata:	45/29 45/77 45/88 45/90 45/91 631/181/735 631/326/193 631/326/596/2554 631/337/1910 Biochemistry, Molecular Biology Biodiversity Circular RNA DNA-directed RNA polymerase Evolution Fungi Fungi - genetics Genomes Genomics Humanities and Social Sciences Hybrids Life Sciences Microbiology and Parasitology Mitochondria multidisciplinary Mycology Populations and Evolution Ribozymes RNA - genetics RNA polymerase RNA viruses RNA Viruses - genetics RNA, Catalytic - genetics RNA, Viral - genetics RNA-Dependent RNA Polymerase - genetics RNA-directed RNA polymerase Science Science (multidisciplinary) Viroids Viroids - genetics Virology Virus Replication - genetics Viruses Fungi Molecular evolution Ribozymes Viral evolution
ISSN:	2041-1723, 2041-1723
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Shrnutí:	Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase (RdRp), whereas viroid-like elements consist of small, single-stranded, circular RNA genomes that, in some cases, encode paired self-cleaving ribozymes. Here we show that the number of candidate viroid-like elements occurring in geographically and ecologically diverse niches is much higher than previously thought. We report that, amongst these circular genomes, fungal ambiviruses are viroid-like elements that undergo rolling circle replication and encode their own viral RdRp. Thus, ambiviruses are distinct infectious RNAs showing hybrid features of viroid-like RNAs and viruses. We also detected similar circular RNAs, containing active ribozymes and encoding RdRps, related to mitochondrial-like fungal viruses, highlighting fungi as an evolutionary hub for RNA viruses and viroid-like elements. Our findings point to a deep co-evolutionary history between RNA viruses and subviral elements and offer new perspectives in the origin and evolution of primordial infectious agents, and RNA life. RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase, while viroid-like elements consist of small, single-stranded, circular RNA genomes that, in some cases, encode self-cleaving catalytic RNAs. Here, the authors identify over 20,000 candidate viroid-like elements, and show that infectious agents of fungi display hybrid features of viroid-like RNAs and RNA viruses.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC10162972
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-023-38301-2