Generalizing RNA velocity to transient cell states through dynamical modeling

RNA velocity has opened up new ways of studying cellular differentiation in single-cell RNA-sequencing data. It describes the rate of gene expression change for an individual gene at a given time point based on the ratio of its spliced and unspliced messenger RNA (mRNA). However, errors in velocity...

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Veröffentlicht in:	Nature biotechnology Jg. 38; H. 12; S. 1408 - 1414
Hauptverfasser:	Bergen, Volker, Lange, Marius, Peidli, Stefan, Wolf, F Alexander, Theis, Fabian J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.12.2020
Schlagworte:	Animals Cell Cycle Cell differentiation Cell Lineage Dentate Gyrus - metabolism Differentiation (biology) Dynamic models Endocrine System - metabolism Gene expression Gene regulation Gene sequencing Humans Kinetics Mice Models, Genetic Neurogenesis Neurogenesis - genetics Pancreas Ribonucleic acid RNA RNA - genetics RNA Splicing - genetics Single-Cell Analysis Splicing Stem Cells - metabolism Stochastic Processes Transcription Transcription, Genetic Velocity
ISSN:	1087-0156, 1546-1696, 1546-1696
Online-Zugang:	Volltext
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