Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

Long-lived species Homo sapiens have evolved robust protection mechanisms against cancer by repressing telomerase and maintaining short telomeres, thereby delaying the onset of the majority of cancer types until post-reproductive age. Indeed, telomerase is silent in most differentiated human cells,...

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Bibliographic Details
Published in:	Oncogene Vol. 38; no. 34; pp. 6172 - 6183
Main Authors:	Yuan, Xiaotian, Larsson, Catharina, Xu, Dawei
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.08.2019 Nature Publishing Group
Subjects:	631/67/395 631/67/68 Apoptosis Cancer Care and treatment Cell Biology Cell differentiation Cell Transformation, Neoplastic - genetics Derepression Development and progression Diagnosis Disease Progression Gene Expression Regulation, Neoplastic Gene regulation Gene silencing Genetic transcription Genetic transformation Genomics Human Genetics Humans Hyperactivity Immortalization Internal Medicine Medicine Medicine & Public Health Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Next-generation sequencing Oncology Post-transcription Promoter Regions, Genetic Review Review Article RNA-directed DNA polymerase Senescence Telomerase Telomerase - genetics Telomerase - metabolism Telomerase reverse transcriptase Telomere - genetics Telomere - metabolism Telomere Homeostasis - genetics Telomere Shortening - genetics Telomeres Therapeutic applications Transcription activation Transcription factors Transcription, Genetic Tumorigenesis
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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