Construct validity of the Post-COVID-19 Functional Status Scale in adult subjects with COVID-19

Background An increasing number of subjects are recovering from COVID-19, raising the need for tools to adequately assess the course of the disease and its impact on functional status. We aimed to assess the construct validity of the Post-COVID-19 Functional Status (PCFS) Scale among adult subjects...

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Published in:Health and quality of life outcomes Vol. 19; no. 1; pp. 40 - 10
Main Authors: Machado, Felipe V. C., Meys, Roy, Delbressine, Jeannet M., Vaes, Anouk W., Goërtz, Yvonne M. J., van Herck, Maarten, Houben-Wilke, Sarah, Boon, Gudula J. A. M., Barco, Stefano, Burtin, Chris, van ’t Hul, Alex, Posthuma, Rein, Franssen, Frits M. E., Spies, Yvonne, Vijlbrief, Herman, Pitta, Fabio, Rezek, Spencer A., Janssen, Daisy J. A., Siegerink, Bob, Klok, Frederikus A., Spruit, Martijn A.
Format: Journal Article
Language:English
Published: London BioMed Central 03.02.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Adult
Belgium
Committees
Convalescence
Coronaviruses
COVID-19
COVID-19 - physiopathology
COVID-19 - psychology
COVID-19 diagnostic tests
Cross-Sectional Studies
Demographic aspects
Disease
Domains
Evaluation
Female
Functional Status
Health aspects
Hospitalization
Humans
Hypotheses
Impairment
Indexing
Infections
Male
Medical ethics
Medicine
Medicine & Public Health
Middle Aged
Netherlands
Quality of Life
Quality of Life Research
Questionnaires
Reproducibility of Results
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Surveys and Questionnaires
Symptoms
Thromboembolism
Validation studies
Validity
Viral diseases
Belgium
Netherlands
United States > US
Functional status
SARS-CoV-2
Symptoms
Quality of life
ISSN:1477-7525, 1477-7525
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Summary:Background An increasing number of subjects are recovering from COVID-19, raising the need for tools to adequately assess the course of the disease and its impact on functional status. We aimed to assess the construct validity of the Post-COVID-19 Functional Status (PCFS) Scale among adult subjects with confirmed and presumed COVID-19. Methods Adult subjects with confirmed and presumed COVID-19, who were members of an online panel and two Facebook groups for subjects with COVID-19 with persistent symptoms, completed an online survey after the onset of infection-related symptoms. The number and intensity of symptoms were evaluated with the Utrecht Symptom Diary, health-related quality of life (HrQoL) with the 5-level EQ-5D questionnaire, impairment in work and activities with the Work Productivity and Activity Impairment questionnaire and functional status with the PCFS Scale. Results 1939 subjects were included in the analyses (85% women, 95% non-hospitalized during infection) about 3 months after the onset of infection-related symptoms. Subjects classified as experiencing ‘slight’, ‘moderate’ and ‘severe’ functional limitations presented a gradual increase in the number/intensity of symptoms, reduction of HrQoL and impairment in work and usual activities. No differences were found regarding the number and intensity of symptoms, HrQoL and impairment in work and usual activities between subjects classified as experiencing ‘negligible’ and ‘no’ functional limitations. We found weak-to-strong statistical associations between functional status and all domains of HrQoL (r: 0.233–0.661). Notably, the strongest association found was with the ‘usual activities’ domain of the 5-level EQ-5D questionnaire. Conclusion We demonstrated the construct validity of the PCFS Scale in highly-symptomatic adult subjects with confirmed and presumed COVID-19, 3 months after the onset of symptoms.
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ISSN:1477-7525
1477-7525
DOI:10.1186/s12955-021-01691-2