Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model

The hippocampal CA2 region is essential for social memory. To determine whether CA2 activity encodes social interactions, we recorded extracellularly from CA2 pyramidal neurons (PNs) in male mice during social behavior. Although CA2 neuronal firing showed only weak spatial selectivity, it accurately...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 23; no. 11; pp. 1365 - 1375
Main Authors:	Donegan, Macayla L, Stefanini, Fabio, Meira, Torcato, Gordon, Joshua A, Fusi, Stefano, Siegelbaum, Steven A
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.11.2020
Subjects:	Action Potentials Animals CA2 Region, Hippocampal - physiology Chromosome Deletion Chromosomes, Human, Pair 22 - physiology Coding Disease Models, Animal Exploratory Behavior - physiology Hippocampus Male Memory Mental disorders Mice, Inbred C57BL Mice, Transgenic Neural coding Neurons Neurosciences Potassium Pyramidal cells Pyramidal Cells - physiology Schizophrenia Selectivity Social Behavior Social factors Social Interaction Social interactions Spatial Processing - physiology
ISSN:	1097-6256, 1546-1726, 1546-1726
Online Access:	Get full text
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