Green Phellodendri Chinensis Cortex-based carbon dots for ameliorating imiquimod-induced psoriasis-like inflammation in mice

Background Carbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug for treating thorny diseases. This study developed a green and simple calcination method to prepare novel CDs as promising drug for psoriasis treatment. The as-prepared CDs using Phelloden...

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Vydáno v:Journal of nanobiotechnology Ročník 19; číslo 1; s. 105 - 14
Hlavní autoři: Zhang, Meiling, Cheng, Jinjun, Hu, Jie, Luo, Juan, Zhang, Yue, Lu, Fang, Kong, Hui, Qu, Huihua, Zhao, Yan
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 15.04.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Antiviral drugs
Biological activity
Biotechnology
Carbon
Carbon dots
Care and treatment
Chemistry
Chemistry and Materials Science
Cytokines
Cytotoxicity
Drug dosages
Electron microscopy
Erythema
Fluorescence
Fourier transforms
Health aspects
Imiquimod
Inflammation
Macrophage polarization
Macrophages
Medicinal plants
Molecular Medicine
Morphology
Nanotechnology
Optical properties
Phellodendri Chinensis Cortex-based carbon dots
Photoelectron spectroscopy
Photoelectrons
Polarization
Protective effect
Psoriasis
Quantum dots
Rutaceae
Skin
Spectrum analysis
Spleen
X ray photoelectron spectroscopy
China
Protective effect
Phellodendri Chinensis Cortex-based carbon dots
Psoriasis
Macrophage polarization
Imiquimod
ISSN:1477-3155, 1477-3155
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Shrnutí:Background Carbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug for treating thorny diseases. This study developed a green and simple calcination method to prepare novel CDs as promising drug for psoriasis treatment. The as-prepared CDs using Phellodendri Chinensis Cortex (PCC) as sole precursor were characterized by a series of methods, mainly including electron microscopy, optical technology and X-ray photoelectron spectroscopy (XPS). Results Results displayed that fluorescence (Quantum yield = 5.63%) and nontoxic PCC-based CDs (PCC-CDs) with abundant chemical groups exhibited solubility and tiny sizes at average of (1.93 ± 0.53) nm, which may be beneficial for its inherent biological activity. Moreover, by using the typical imiquimod (IMQ)-induced psoriasis-like skin mouse model, we firstly demonstrated the pronounced anti-psoriasis activity of as-prepared PCC-CDs on ameliorating the appearance, psoriasis area and severity index (PASI) scores as well as histopathological morphology of both back skin tissues and right ears in IMQ-induced mouse. Further potential mechanisms behind the anti-psoriasis activities may be related to suppress M1 polarization and relatively promote M2 polarization of macrophage both in vitro and in vivo. Conclusion These results suggested that PCC-CDs have potential to be an anti-psoriasis candidate for clinical applications to treat psoriasis, which not only provided an evidence for further broadening the biological application of CDs, but also provided a potential hope for application nanodrugs to treat thorny diseases. Graphic Abstract
Bibliografie:ObjectType-Article-1
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ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-021-00847-y