The interplay between oxidative stress and autophagy: focus on the development of neurological diseases

Regarding the epidemiological studies, neurological dysfunctions caused by cerebral ischemia or neurodegenerative diseases (NDDs) have been considered a pointed matter. Mount-up shreds of evidence support that both autophagy and reactive oxygen species (ROS) are involved in the commencement and prog...

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Vydáno v:Behavioral and brain functions Ročník 18; číslo 1; s. 3 - 22
Hlavní autoři: Talebi, Marjan, Mohammadi Vadoud, Seyyed Ali, Haratian, Alireza, Talebi, Mohsen, Farkhondeh, Tahereh, Pourbagher-Shahri, Ali Mohammad, Samarghandian, Saeed
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 29.01.2022
Springer Nature B.V
BMC
Témata:
Autophagy
Behavioral Therapy
Biomedical and Life Sciences
Biomedicine
Cellular and molecular mechanisms
Cytoplasm
Cytotoxicity
Epidemiology
Genes
Homeostasis
Humans
Hydrogen peroxide
Hypoxia
Ischemia
Kinases
Membranes
Mitochondria
Molecular modelling
Neurodegenerative Diseases
Neurological diseases
Neurological disorders
Neurology
Neurosciences
Oxidative Stress
Phosphorylation
Proteins
Psychiatry
Reactive Oxygen Species
Review
Signaling pathways, Alzheimer’s disease, Parkinson’s disease, Reactive Oxygen Species (ROS)
Neurological diseases
Oxidative stress
Neurodegenerative diseases
Signaling pathways, Alzheimer’s disease, Parkinson’s disease, Reactive Oxygen Species (ROS)
Autophagy
ISSN:1744-9081, 1744-9081
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Shrnutí:Regarding the epidemiological studies, neurological dysfunctions caused by cerebral ischemia or neurodegenerative diseases (NDDs) have been considered a pointed matter. Mount-up shreds of evidence support that both autophagy and reactive oxygen species (ROS) are involved in the commencement and progression of neurological diseases. Remarkably, oxidative stress prompted by an increase of ROS threatens cerebral integrity and improves the severity of other pathogenic agents such as mitochondrial damage in neuronal disturbances. Autophagy is anticipated as a cellular defending mode to combat cytotoxic substances and damage. The recent document proposes that the interrelation of autophagy and ROS creates a crucial function in controlling neuronal homeostasis. This review aims to overview the cross-talk among autophagy and oxidative stress and its molecular mechanisms in various neurological diseases to prepare new perceptions into a new treatment for neurological disorders. Furthermore, natural/synthetic agents entailed in modulation/regulation of this ambitious cross-talk are described.
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ISSN:1744-9081
1744-9081
DOI:10.1186/s12993-022-00187-3