Challenges on optimization of 3D-printed bone scaffolds

Advances in biomaterials and the need for patient-specific bone scaffolds require modern manufacturing approaches in addition to a design strategy. Hybrid materials such as those with functionally graded properties are highly needed in tissue replacement and repair. However, their constituents, prop...

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Bibliographic Details
Published in:Biomedical engineering online Vol. 19; no. 1; pp. 69 - 33
Main Author: Bahraminasab, Marjan
Format: Journal Article
Language:English
Published: London BioMed Central 03.09.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
3-D printers
3D printing
Additive manufacturing
Artificial bone
Biocompatibility
Biomaterials
Biomedical Engineering and Bioengineering
Biomedical Engineering/Biotechnology
Biomedical materials
Biomimetic materials
Bioprinting
Biotechnology
Bone and Bones - cytology
Bone biomaterials
Bones
CAD
Cell adhesion & migration
Composites
Computational design
Computer aided design
Customized bone scaffold
Data acquisition
Defects
Engineering
Functionally graded materials
Functionally gradient materials
Geometry
Humans
Magnetic resonance imaging
Manufacturing
Mathematical models
Medical imaging
Methods
Optimization
Pore size
Porosity
Printing, Three-Dimensional
Process parameters
Production processes
Reverse engineering
Review
Scaffolds
Software
Three dimensional models
Three dimensional printing
Tissue Engineering
Tissue Scaffolds
Iran
Bioprinting
Composites
Customized bone scaffold
Functionally graded materials
Computational design
Metadata analysis
Additive manufacturing
ISSN:1475-925X, 1475-925X
Online Access:Get full text
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Description
Summary:Advances in biomaterials and the need for patient-specific bone scaffolds require modern manufacturing approaches in addition to a design strategy. Hybrid materials such as those with functionally graded properties are highly needed in tissue replacement and repair. However, their constituents, proportions, sizes, configurations and their connection to each other are a challenge to manufacturing. On the other hand, various bone defect sizes and sites require a cost-effective readily adaptive manufacturing technique to provide components (scaffolds) matching with the anatomical shape of the bone defect. Additive manufacturing or three-dimensional (3D) printing is capable of fabricating functional physical components with or without porosity by depositing the materials layer-by-layer using 3D computer models. Therefore, it facilitates the production of advanced bone scaffolds with the feasibility of making changes to the model. This review paper first discusses the development of a computer-aided-design (CAD) approach for the manufacture of bone scaffolds, from the anatomical data acquisition to the final model. It also provides information on the optimization of scaffold’s internal architecture, advanced materials, and process parameters to achieve the best biomimetic performance. Furthermore, the review paper describes the advantages and limitations of 3D printing technologies applied to the production of bone tissue scaffolds.
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ISSN:1475-925X
1475-925X
DOI:10.1186/s12938-020-00810-2