Challenges on optimization of 3D-printed bone scaffolds

Advances in biomaterials and the need for patient-specific bone scaffolds require modern manufacturing approaches in addition to a design strategy. Hybrid materials such as those with functionally graded properties are highly needed in tissue replacement and repair. However, their constituents, prop...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Biomedical engineering online Ročník 19; číslo 1; s. 69 - 33
Hlavní autor:	Bahraminasab, Marjan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 03.09.2020 BioMed Central Ltd Springer Nature B.V BMC
Témata:	3-D printers 3D printing Additive manufacturing Artificial bone Biocompatibility Biomaterials Biomedical Engineering and Bioengineering Biomedical Engineering/Biotechnology Biomedical materials Biomimetic materials Bioprinting Biotechnology Bone and Bones - cytology Bone biomaterials Bones CAD Cell adhesion & migration Composites Computational design Computer aided design Customized bone scaffold Data acquisition Defects Engineering Functionally graded materials Functionally gradient materials Geometry Humans Magnetic resonance imaging Manufacturing Mathematical models Medical imaging Methods Optimization Pore size Porosity Printing, Three-Dimensional Process parameters Production processes Reverse engineering Review Scaffolds Software Three dimensional models Three dimensional printing Tissue Engineering Tissue Scaffolds Iran Bioprinting Composites Customized bone scaffold Functionally graded materials Computational design Metadata analysis Additive manufacturing
ISSN:	1475-925X, 1475-925X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Advances in biomaterials and the need for patient-specific bone scaffolds require modern manufacturing approaches in addition to a design strategy. Hybrid materials such as those with functionally graded properties are highly needed in tissue replacement and repair. However, their constituents, proportions, sizes, configurations and their connection to each other are a challenge to manufacturing. On the other hand, various bone defect sizes and sites require a cost-effective readily adaptive manufacturing technique to provide components (scaffolds) matching with the anatomical shape of the bone defect. Additive manufacturing or three-dimensional (3D) printing is capable of fabricating functional physical components with or without porosity by depositing the materials layer-by-layer using 3D computer models. Therefore, it facilitates the production of advanced bone scaffolds with the feasibility of making changes to the model. This review paper first discusses the development of a computer-aided-design (CAD) approach for the manufacture of bone scaffolds, from the anatomical data acquisition to the final model. It also provides information on the optimization of scaffold’s internal architecture, advanced materials, and process parameters to achieve the best biomimetic performance. Furthermore, the review paper describes the advantages and limitations of 3D printing technologies applied to the production of bone tissue scaffolds.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1475-925X 1475-925X
DOI:	10.1186/s12938-020-00810-2