Somatic mutations render human exome and pathogen DNA more similar

Immunotherapy has recently shown important clinical successes in a substantial number of oncology indications. Additionally, the tumor somatic mutation load has been shown to associate with response to these therapeutic agents, and specific mutational signatures are hypothesized to improve this asso...

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Veröffentlicht in:	PloS one Jg. 14; H. 5; S. e0197949
Hauptverfasser:	Ebrahimzadeh, Ehsan, Engler, Maggie, Tse, David, Cristescu, Razvan, Tchamkerten, Aslan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.05.2019 Public Library of Science (PLoS)
Schlagworte:	Amino acids Biology and Life Sciences Bladder cancer Cancer Cancer research Cancer therapies Cell division Chemical compounds Colorectal cancer Deoxyribonucleic acid DNA DNA - genetics Electrical engineering Exome - genetics Exposure Gene mutation Gene sequencing Genetic research Genome, Human - genetics Genomes Health aspects Humans Immune response Immune system Immunogenicity Immunological tolerance Immunotherapy Infiltration Ipilimumab Load Lung cancer Lung diseases Lymphocytes Medicine and Health Sciences Melanoma Metastases Metastasis Mutation Mutation - genetics Mutation Rate Mutation rates Neoplasms - genetics Nucleotide sequence Oncology Pathogenic microorganisms Pathogens Peptides Pharmacology Recognition Research and Analysis Methods Signatures Similarity Smoking Tumors Ultraviolet radiation United States > US California
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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