Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Background Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-indu...

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Veröffentlicht in:	Current controlled trials in cardiovascular medicine Jg. 23; H. 1; S. 928 - 13
Hauptverfasser:	Maitre, Thomas, Bonnet, Maryline, Calmy, Alexandra, Raberahona, Mihaja, Rakotoarivelo, Rivonirina Andry, Rakotosamimanana, Niaina, Ambrosioni, Juan, Miró, José M., Debeaudrap, Pierre, Muzoora, Conrad, Davis, Angharad, Meintjes, Graeme, Wasserman, Sean, Wilkinson, Robert, Eholié, Serge, Nogbou, Frédéric Ello, Calvo-Cortes, Maria-Camilla, Chazallon, Corine, Machault, Vanessa, Anglaret, Xavier, Bonnet, Fabrice
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 08.11.2022 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Adolescent Adult Antitubercular Agents - adverse effects Aspirin Aspirin - therapeutic use Biomedicine Care and treatment Cerebrospinal fluid Clinical trials Clinical Trials, Phase III as Topic Diagnosis Dosage and administration Drug dosages Drug resistance Health Sciences HIV HIV infection HIV Infections - complications HIV Infections - diagnosis HIV Infections - drug therapy HIV, High-dose rifampicin Human immunodeficiency virus Humans Life Sciences Linezolid Medicine Medicine & Public Health Meningitis Metabolism Mortality Multicenter Studies as Topic Patient outcomes Patients Peripheral neuropathy Pharmacokinetics Randomized controlled trial Randomized Controlled Trials as Topic Rifampin Santé publique et épidémiologie South Africa - epidemiology Statistics for Life Sciences Study Protocol Testing Tuberculosis Tuberculosis, Meningeal - diagnosis Tuberculosis, Meningeal - drug therapy Tuberculous meningitis South Africa Sub-Saharan Africa Uganda Madagascar Ivory Coast Linezolid Aspirin Randomized controlled trial HIV, High-dose rifampicin Tuberculous meningitis HIV High-dose rifampicin
ISSN:	1745-6215, 1745-6215
Online-Zugang:	Volltext
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