Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes

Introduction The presence of tumor-infiltrating lymphocytes (TILs) is correlated with good prognosis and outcome after (immuno)therapy in triple-negative and HER2-positive breast cancer. However, the role of TILs in luminal breast cancer is less clear. Emerging evidence has now demonstrated that gen...

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Bibliographic Details
Published in:	Breast cancer research : BCR Vol. 21; no. 1; pp. 90 - 12
Main Authors:	Sobral-Leite, Marcelo, Salomon, Izhar, Opdam, Mark, Kruger, Dinja T., Beelen, Karin J., van der Noort, Vincent, van Vlierberghe, Ronald L. P., Blok, Erik J., Giardiello, Daniele, Sanders, Joyce, Van de Vijver, Koen, Horlings, Hugo M., Kuppen, Peter J. K., Linn, Sabine C., Schmidt, Marjanka K., Kok, Marleen
Format:	Journal Article
Language:	English
Published:	London BioMed Central 07.08.2019 BioMed Central Ltd BMC
Subjects:	Adjuvant chemotherapy Analysis Biomarkers, Tumor Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Care and treatment Cellular signal transduction Disease Susceptibility - immunology Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Profiling Genetic aspects Humans Immunohistochemistry Immunotherapy Luminal breast cancer Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Mutation Neoplasm Staging Neoplasms - etiology Neoplasms - metabolism Neoplasms - mortality Neoplasms - pathology Oncology Outcome and process assessment (Medical care) Phosphatidylinositol 3-Kinase - genetics Phosphatidylinositol 3-Kinase - metabolism Phospholipids PI3K pathway PIK3CA mutations Postmenopausal women Prognosis Proteins Receptors, Estrogen - metabolism Research Article Surgical Oncology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology Tamoxifen Transcriptome Tumor-infiltrating lymphocytes Tumors PI3K pathway mutations Tumor-infiltrating lymphocytes Luminal breast cancer PIK3CA mutations
ISSN:	1465-542X, 1465-5411, 1465-542X
Online Access:	Get full text
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