Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)

Background The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic lupus erythematosus (SLE). However, neuropsychiatric manifestations in this model have not been investigated in detail. Because neuropsychiatric lupus (NPSLE) is an important complication o...

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Vydáno v:	Behavioral and brain functions Ročník 19; číslo 1; s. 3 - 19
Hlavní autoři:	Yun, Yang, Wang, Xuejiao, Xu, Jingyi, Jin, Chenye, Chen, Jingyu, Wang, Xueru, Wang, Jianing, Qin, Ling, Yang, Pingting
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 10.02.2023 Springer Nature B.V BMC
Témata:	Age Animals Anxiety Arthritis Astrocytes Behavior Behavioral deficit Behavioral Therapy Biomedical and Life Sciences Biomedicine Blood-brain barrier Brain research Chemokines Chemokines - therapeutic use Choroid plexus CXCL10 protein Cytokine Cytokines Genotype & phenotype Glia cells Hippocampus IgG Immunoglobulin G Interleukin 10 Interleukin 6 Lupus Lupus Erythematosus, Systemic Lupus Vasculitis, Central Nervous System - chemically induced Lupus Vasculitis, Central Nervous System - diagnosis Lupus Vasculitis, Central Nervous System - drug therapy Membrane permeability Mice Microglia Monocyte chemoattractant protein 1 Mouse model Neurological complications Neurology Neuropsychiatric lupus Neurosciences Olfaction Pathogenesis Phenotypes Pristane Psychiatry Systemic lupus erythematosus Therapeutic targets Tumor necrosis factor-TNF Tumor necrosis factor-α Ventricle Ventricles (cerebral) α-Interferon β-Interferon γ-Interferon Cytokine IgG Mouse model Behavioral deficit Lipofuscin Neuropsychiatric lupus Glia cells
ISSN:	1744-9081, 1744-9081
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Popis
Shrnutí:	Background The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic lupus erythematosus (SLE). However, neuropsychiatric manifestations in this model have not been investigated in detail. Because neuropsychiatric lupus (NPSLE) is an important complication of SLE, we investigated the neuropsychiatric symptoms in the PIL mouse model to evaluate its suitability for NPSLE studies. Results PIL mice showed olfactory dysfunction accompanied by an anxiety- and depression-like phenotype at month 2 or 4 after pristane injection. The levels of cytokines (IL-1β, IFN-α, IFN-β, IL-10, IFN-γ, IL-6, TNF-α and IL-17A) and chemokines (CCL2 and CXCL10) in the brain and blood–brain barrier (BBB) permeability increased significantly from week 2 or month 1, and persisted throughout the observed course of the disease. Notably, IgG deposition in the choroid plexus and lateral ventricle wall were observed at month 1 and both astrocytes and microglia were activated. Persistent activation of astrocytes was detected throughout the observed course of the disease, while microglial activation diminished dramatically at month 4. Lipofuscin deposition, a sign of neuronal damage, was detected in cortical and hippocampal neurons from month 4 to 8. Conclusion PIL mice exhibit a series of characteristic behavioral deficits and pathological changes in the brain, and therefore might be suitable for investigating disease pathogenesis and for evaluating potential therapeutic targets for environmental-related NPSLE.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1744-9081 1744-9081
DOI:	10.1186/s12993-023-00205-y