Biocatalysis: Enzymatic Synthesis for Industrial Applications

Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, bioca...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 60; no. 1; pp. 88 - 119
Main Authors: Wu, Shuke, Snajdrova, Radka, Moore, Jeffrey C., Baldenius, Kai, Bornscheuer, Uwe T.
Format: Journal Article
Language:English
Published: Germany Wiley Subscription Services, Inc 04.01.2021
John Wiley and Sons Inc
Edition:International ed. in English
Subjects:
Biocatalysis
Biocatalysts
Biotechnology - methods
Catalysis
Enzymatic synthesis
enzyme catalysis
Enzymes
Enzymes - metabolism
Industrial applications
industrial catalysis
organic synthesis
Review
Reviews
stereoselectivity
industrial catalysis
enzyme catalysis
stereoselectivity
organic synthesis
biocatalysis
ISSN:1433-7851, 1521-3773, 1521-3773
Online Access:Get full text
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Summary:Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are used on a large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using enzymes. It also discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes. Biocatalysis has developed into a mature technology for chemical and pharmaceutical synthesis as well as other areas where high selectivity and mild reaction conditions are required. This Review highlights recent achievements with a special focus on industrialized applications including the introduction of key performance indicators (KPIs) to judge the efficiency of enzymes.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.202006648