Biocatalysis: Enzymatic Synthesis for Industrial Applications

Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, bioca...

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Vydané v:	Angewandte Chemie International Edition Ročník 60; číslo 1; s. 88 - 119
Hlavní autori:	Wu, Shuke, Snajdrova, Radka, Moore, Jeffrey C., Baldenius, Kai, Bornscheuer, Uwe T.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Germany Wiley Subscription Services, Inc 04.01.2021 John Wiley and Sons Inc
Vydanie:	International ed. in English
Predmet:	Biocatalysis Biocatalysts Biotechnology - methods Catalysis Enzymatic synthesis enzyme catalysis Enzymes Enzymes - metabolism Industrial applications industrial catalysis organic synthesis Review Reviews stereoselectivity industrial catalysis enzyme catalysis stereoselectivity organic synthesis biocatalysis
ISSN:	1433-7851, 1521-3773, 1521-3773
On-line prístup:	Získať plný text
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Abstract	Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are used on a large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using enzymes. It also discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes. Biocatalysis has developed into a mature technology for chemical and pharmaceutical synthesis as well as other areas where high selectivity and mild reaction conditions are required. This Review highlights recent achievements with a special focus on industrialized applications including the introduction of key performance indicators (KPIs) to judge the efficiency of enzymes.
AbstractList	Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are used on a large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using enzymes. It also discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes. Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are used on a large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using enzymes. It also discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes. Biocatalysis has developed into a mature technology for chemical and pharmaceutical synthesis as well as other areas where high selectivity and mild reaction conditions are required. This Review highlights recent achievements with a special focus on industrialized applications including the introduction of key performance indicators (KPIs) to judge the efficiency of enzymes. Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are used on a large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using enzymes. It also discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes. Biocatalysis has developed into a mature technology for chemical and pharmaceutical synthesis as well as other areas where high selectivity and mild reaction conditions are required. This Review highlights recent achievements with a special focus on industrialized applications including the introduction of key performance indicators (KPIs) to judge the efficiency of enzymes. Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are used on a large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using enzymes. It also discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes.Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are used on a large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using enzymes. It also discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes.
Author	Baldenius, Kai Wu, Shuke Snajdrova, Radka Bornscheuer, Uwe T. Moore, Jeffrey C.
AuthorAffiliation	4 Baldenius Biotech Consulting Hafenstr. 31 68159 Mannheim Germany 1 Institute of Biochemistry Dept. of Biotechnology & Enzyme Catalysis Greifswald University Felix-Hausdorff-Strasse 4 17487 Greifswald Germany 2 Novartis Institutes for BioMedical Research Global Discovery Chemistry 4056 Basel Switzerland 3 Process Research and Development Merck & Co., Inc. 126 E. Lincoln Ave Rahway NJ 07065 USA
AuthorAffiliation_xml	– name: 2 Novartis Institutes for BioMedical Research Global Discovery Chemistry 4056 Basel Switzerland – name: 3 Process Research and Development Merck & Co., Inc. 126 E. Lincoln Ave Rahway NJ 07065 USA – name: 1 Institute of Biochemistry Dept. of Biotechnology & Enzyme Catalysis Greifswald University Felix-Hausdorff-Strasse 4 17487 Greifswald Germany – name: 4 Baldenius Biotech Consulting Hafenstr. 31 68159 Mannheim Germany
Author_xml	– sequence: 1 givenname: Shuke orcidid: 0000-0003-0914-9277 surname: Wu fullname: Wu, Shuke organization: Greifswald University – sequence: 2 givenname: Radka orcidid: 0000-0002-4809-1066 surname: Snajdrova fullname: Snajdrova, Radka organization: Novartis Institutes for BioMedical Research – sequence: 3 givenname: Jeffrey C. orcidid: 0000-0002-9807-6315 surname: Moore fullname: Moore, Jeffrey C. organization: Merck & Co., Inc – sequence: 4 givenname: Kai orcidid: 0000-0003-2404-9418 surname: Baldenius fullname: Baldenius, Kai email: kai@baldenius.com organization: Baldenius Biotech Consulting – sequence: 5 givenname: Uwe T. orcidid: 0000-0003-0685-2696 surname: Bornscheuer fullname: Bornscheuer, Uwe T. email: uwe.bornscheuer@uni-greifswald.de organization: Greifswald University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32558088$$D View this record in MEDLINE/PubMed
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OpenAccessLink	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fanie.202006648
PMID	32558088
PQID	2471724284
PQPubID	946352
PageCount	32
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_7818486 proquest_miscellaneous_2415288538 proquest_journals_2471724284 pubmed_primary_32558088 crossref_primary_10_1002_anie_202006648 crossref_citationtrail_10_1002_anie_202006648 wiley_primary_10_1002_anie_202006648_ANIE202006648
PublicationCentury	2000
PublicationDate	January 4, 2021
PublicationDateYYYYMMDD	2021-01-04
PublicationDate_xml	– month: 01 year: 2021 text: January 4, 2021 day: 04
PublicationDecade	2020
PublicationPlace	Germany
PublicationPlace_xml	– name: Germany – name: Weinheim – name: Hoboken
PublicationTitle	Angewandte Chemie International Edition
PublicationTitleAlternate	Angew Chem Int Ed Engl
PublicationYear	2021
Publisher	Wiley Subscription Services, Inc John Wiley and Sons Inc
Publisher_xml	– name: Wiley Subscription Services, Inc – name: John Wiley and Sons Inc
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Snippet	Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to...
SourceID	pubmedcentral proquest pubmed crossref wiley
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	88
SubjectTerms	Biocatalysis Biocatalysts Biotechnology - methods Catalysis Enzymatic synthesis enzyme catalysis Enzymes Enzymes - metabolism Industrial applications industrial catalysis organic synthesis Review Reviews stereoselectivity
Title	Biocatalysis: Enzymatic Synthesis for Industrial Applications
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Volume	60
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