Amelioration of TMAO through probiotics and its potential role in atherosclerosis

Atherosclerosis is a major cause of mortalities and morbidities worldwide. It is associated with hyperlipidemia and inflammation, and become chronic by triggering metabolites in different metabolic pathways. Disturbance in the human gut microbiota is now considered a critical factor in the atheroscl...

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Vydáno v:	Applied microbiology and biotechnology Ročník 103; číslo 23-24; s. 9217 - 9228
Hlavní autoři:	Din, Ahmad Ud, Hassan, Adil, Zhu, Yuan, Yin, Tieying, Gregersen, Hans, Wang, Guixue
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2019 Springer Springer Nature B.V
Témata:	Animals Arteriosclerosis Atherosclerosis Atherosclerosis - physiopathology Atherosclerosis - prevention & control biochemical pathways Biomedical and Life Sciences Biosynthesis Biotechnology Canada Cardiovascular disease Carnitine Cholesterol Choline Diabetes Diet Flavin flavin-containing monooxygenase Health aspects Heart failure Humans Hyperlipidemia Immune system Inflammation Intestinal microflora intestinal microorganisms Lecithin Life Sciences Lipids Metabolic disorders Metabolic pathways Metabolites Metabolomics Methylamines - antagonists & inhibitors Methylamines - metabolism Mice Microbial Genetics and Genomics Microbiology Microbiomes Microbiota Microbiota (Symbiotic organisms) Microorganisms microRNA MicroRNAs Mini-Review miRNA Mortality oxidation Phosphatidylcholine phosphatidylcholines Prevention Probiotics Probiotics - therapeutic use Risk factors Trimethylamine Trimethylamine-N-oxide Type 2 diabetes Canada Gut microbiota TMAO Probiotics TMA lyases Atherosclerosis
ISSN:	0175-7598, 1432-0614, 1432-0614
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Shrnutí:	Atherosclerosis is a major cause of mortalities and morbidities worldwide. It is associated with hyperlipidemia and inflammation, and become chronic by triggering metabolites in different metabolic pathways. Disturbance in the human gut microbiota is now considered a critical factor in the atherosclerosis. Trimethylamine-N-oxide (TMAO) attracts attention and is regarded as a vital contributor in the development of atherosclerosis. TMAO is generated from its dietary precursors choline, carnitine, and phosphatidylcholine by gut microbiota into an intermediate compound known as trimethylamine (TMA), which is then oxidized into TMAO by hepatic flavin monooxygenases. The present review focus on advances in TMAO preventing strategies through probiotics, including, modulation of gut microbiome, metabolomics profile, miRNA, or probiotic antagonistic abilities. Furthermore, possible recommendations based on relevant literature have been presented, which could be applied in probiotics and atherosclerosis-preventing strategies.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23
ISSN:	0175-7598 1432-0614 1432-0614
DOI:	10.1007/s00253-019-10142-4