The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Acute myeloid leukemia (AML) remains incurable, largely due to its resistance to conventional treatments. Here, we find that increased abundance of the ubiquitin ligase RNF5 contributes to AML development and survival. High RNF5 expression in AML patient specimens correlates with poor prognosis. RNF...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 5397 - 17
Main Authors:	Khateb, Ali, Deshpande, Anagha, Feng, Yongmei, Finlay, Darren, Lee, Joo Sang, Lazar, Ikrame, Fabre, Bertrand, Li, Yan, Fujita, Yu, Zhang, Tongwu, Yin, Jun, Pass, Ian, Livneh, Ido, Jeremias, Irmela, Burian, Carol, Mason, James R., Almog, Ronit, Horesh, Nurit, Ofran, Yishai, Brown, Kevin, Vuori, Kristiina, Jackson, Michael, Ruppin, Eytan, Deshpande, Aniruddha J., Ronai, Ze’ev A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.09.2021 Nature Publishing Group Nature Portfolio
Subjects:	13 38 38/61 631/337/458/582 631/67/1990/283/1897 631/80/304 64 64/60 82/1 82/80 96 96/95 Acute Disease Acute myeloid leukemia Animals Biochemistry, Molecular Biology Cell culture Cell Line, Tumor DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenetics Female Gene regulation Genetic Predisposition to Disease - genetics HEK293 Cells Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histones HL-60 Cells Humanities and Social Sciences Humans Inhibitors K562 Cells Leukemia Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemia, Myeloid - metabolism Leukemogenesis Life Sciences Medical prognosis Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Mice, SCID multidisciplinary Myeloid leukemia Patients Prognosis Science Science (multidisciplinary) Sensitivity enhancement Substrates Survival Transcription Tumorigenesis U937 Cells Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Xenograft Model Antitumor Assays - methods Xenografts Xenotransplantation
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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