Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

Bispecific antibodies that connect T cells with tumor cells can be delivered in the form of in vitro –transcribed pharmacologically optimized mRNA; when injected into mice, these mRNA-encoded antibodies reject large established tumors as efficiently as the corresponding recombinant antibody protein....

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Veröffentlicht in:	Nature medicine Jg. 23; H. 7; S. 815 - 817
Hauptverfasser:	Stadler, Christiane R, Bähr-Mahmud, Hayat, Celik, Leyla, Hebich, Bernhard, Roth, Alexandra S, Roth, René P, Karikó, Katalin, Türeci, Özlem, Sahin, Ugur
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.07.2017 Nature Publishing Group
Schlagworte:	13/1 13/109 13/31 13/51 38/1 42/109 631/61/51/1568 692/699/67/580 692/700/565/1436/152 82/1 82/29 Animals Antibodies Antibodies, Bispecific - genetics Antibodies, Bispecific - immunology Biomedicine Bispecific antibodies brief-communication Cancer Research Cell Line, Tumor Cells Coding Cytokines Cytokines - drug effects Cytokines - immunology Cytotoxicity Dosage and administration Drug dosages Drug therapy Enzyme-Linked Immunosorbent Assay Female Humans Immunoblotting Immunoglobulins Immunohistochemistry In vitro methods and tests In Vitro Techniques Infectious Diseases Luminescent Measurements Lymphocytes Lymphocytes T Male Manufacturing Medical research Messenger RNA Metabolic Diseases Mice Mice, Inbred BALB C Mice, Inbred NOD Molecular Medicine Monoclonal antibodies mRNA Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy Neurosciences Ovaries Pharmacology Plasma Proteins Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - pharmacology T cell receptors T cells T-Lymphocytes - drug effects Tumor Burden - drug effects Tumor cells Tumors Xenograft Model Antitumor Assays
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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