[11C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients

Background P-glycoprotein (P-gp) is an efflux transporter which is abundantly expressed at the blood-brain barrier (BBB) and which has been implicated in the pathophysiology of various brain diseases. The radiolabelled antiemetic drug [ 11 C]metoclopramide is a P-gp substrate for positron emission t...

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Published in:	Fluids and barriers of the CNS Vol. 21; no. 1; pp. 87 - 12
Main Authors:	Biali, Myriam El, Breuil, Louise, Jackwerth, Matthias, Mairinger, Severin, Weber, Maria, Wölfl-Duchek, Michael, Bamminger, Karsten, Rausch, Ivo, Nics, Lukas, Hacker, Marcus, Rodrigo, Sebastian, Bouilleret, Viviane, Zeitlinger, Markus, Pataraia, Ekaterina, Tournier, Nicolas, Bauer, Martin, Langer, Oliver
Format:	Journal Article
Language:	English
Published:	London BioMed Central 28.10.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	[11C]Metoclopramide Adult Anticonvulsants ATP Binding Cassette Transporter, Subfamily B, Member 1 ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biomedical and Life Sciences Biomedicine Blood Blood-Brain Barrier Blood-Brain Barrier - diagnostic imaging Blood-Brain Barrier - metabolism Brain Brain - diagnostic imaging Brain - metabolism Brain diseases Carbon Radioisotopes Carbon Radioisotopes - pharmacokinetics Central nervous system Central nervous system depressants Choroid plexus Convulsions & seizures Disease resistance Drug dosages Drug resistance Drug Resistant Epilepsy Drug Resistant Epilepsy - diagnostic imaging Drug Resistant Epilepsy - metabolism Epilepsy Epilepsy, Temporal Lobe Epilepsy, Temporal Lobe - diagnostic imaging Epilepsy, Temporal Lobe - metabolism Female Glycoproteins Hematology Hippocampus Human health and pathology Humans Life Sciences Magnetic Resonance Imaging Magnetic Resonance Imaging - methods Male Medical examination Medical research Medicine, Experimental Metabolites Metoclopramide Middle Aged Neurobiology Neuroimaging Neurosciences P-Glycoprotein Pathophysiology Patients PET PET imaging Pharmaceutical sciences Pharmacology Plasma Positron emission tomography Positron-Emission Tomography - methods Seizures Seizures (Medicine) Seizures - diagnostic imaging Seizures - metabolism Superior temporal gyrus Temporal gyrus Temporal lobe Tomography Up-Regulation Up-Regulation - physiology Young Adult Connecticut Germany P-glycoprotein Drug-resistant epilepsy [ Blood-brain barrier C]Metoclopramide PET [11C]Metoclopramide
ISSN:	2045-8118, 2045-8118
Online Access:	Get full text
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