The challenge of mapping the human connectome based on diffusion tractography

Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tracto...

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Vydáno v:	Nature communications Ročník 8; číslo 1; s. 1349 - 13
Hlavní autoři:	Maier-Hein, Klaus H., Neher, Peter F., Houde, Jean-Christophe, Côté, Marc-Alexandre, Garyfallidis, Eleftherios, Zhong, Jidan, Chamberland, Maxime, Yeh, Fang-Cheng, Lin, Ying-Chia, Ji, Qing, Reddick, Wilburn E., Glass, John O., Chen, David Qixiang, Feng, Yuanjing, Gao, Chengfeng, Wu, Ye, Ma, Jieyan, He, Renjie, Li, Qiang, Westin, Carl-Fredrik, Deslauriers-Gauthier, Samuel, González, J. Omar Ocegueda, Paquette, Michael, St-Jean, Samuel, Girard, Gabriel, Rheault, François, Sidhu, Jasmeen, Tax, Chantal M. W., Guo, Fenghua, Mesri, Hamed Y., Dávid, Szabolcs, Froeling, Martijn, Heemskerk, Anneriet M., Leemans, Alexander, Boré, Arnaud, Pinsard, Basile, Bedetti, Christophe, Desrosiers, Matthieu, Brambati, Simona, Doyon, Julien, Sarica, Alessia, Vasta, Roberta, Cerasa, Antonio, Quattrone, Aldo, Yeatman, Jason, Khan, Ali R., Hodges, Wes, Alexander, Simon, Romascano, David, Barakovic, Muhamed, Auría, Anna, Esteban, Oscar, Lemkaddem, Alia, Thiran, Jean-Philippe, Cetingul, H. Ertan, Odry, Benjamin L., Mailhe, Boris, Nadar, Mariappan S., Pizzagalli, Fabrizio, Prasad, Gautam, Villalon-Reina, Julio E., Galvis, Justin, Thompson, Paul M., Requejo, Francisco De Santiago, Laguna, Pedro Luque, Lacerda, Luis Miguel, Barrett, Rachel, Dell’Acqua, Flavio, Catani, Marco, Petit, Laurent, Caruyer, Emmanuel, Daducci, Alessandro, Dyrby, Tim B., Holland-Letz, Tim, Hilgetag, Claus C., Stieltjes, Bram, Descoteaux, Maxime
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 07.11.2017 Nature Publishing Group Nature Portfolio
Témata:	631/114 631/378 692/308 692/698/1688 Algorithms Brain Brain - diagnostic imaging Bundles Bundling Computer Science Computer simulation Connectome Databases, Factual Diffusion Tensor Imaging - methods Ground truth Humanities and Social Sciences Humans Image Processing, Computer-Assisted - methods Image Processing, Computer-Assisted - statistics & numerical data Innovations Medical Imaging multidisciplinary Neural networks Neuroimaging Reproducibility of Results Science Science (multidisciplinary)
ISSN:	2041-1723, 2041-1723
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Shrnutí:	Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations. Though tractography is widely used, it has not been systematically validated. Here, authors report results from 20 groups showing that many tractography algorithms produce both valid and invalid bundles.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-017-01285-x