Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and bi...

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Vydáno v:Nature communications Ročník 12; číslo 1; s. 5095 - 13
Hlavní autoři: Everson, Todd M., Vives-Usano, Marta, Seyve, Emie, Cardenas, Andres, Lacasaña, Marina, Craig, Jeffrey M., Lesseur, Corina, Baker, Emily R., Fernandez-Jimenez, Nora, Heude, Barbara, Perron, Patrice, Gónzalez-Alzaga, Beatriz, Halliday, Jane, Deyssenroth, Maya A., Karagas, Margaret R., Íñiguez, Carmen, Bouchard, Luigi, Carmona-Sáez, Pedro, Loke, Yuk J., Hao, Ke, Belmonte, Thalia, Charles, Marie A., Martorell-Marugán, Jordi, Muggli, Evelyne, Chen, Jia, Fernández, Mariana F., Tost, Jorg, Gómez-Martín, Antonio, London, Stephanie J., Sunyer, Jordi, Marsit, Carmen J., Lepeule, Johanna, Hivert, Marie-France, Bustamante, Mariona
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 24.08.2021
Nature Publishing Group
Nature Portfolio
Témata:
49
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631/208/176
631/208/177
692/499
Biochemistry, Molecular Biology
Birth
Children
Consortia
Cord blood
Deoxyribonucleic acid
DNA
DNA Methylation
Epigenesis, Genetic
Epigenetics
Female
Fetal Development - drug effects
Fetal Development - genetics
Fetuses
Gene expression
Genetic Heterogeneity
Genetics
Genomics
Humanities and Social Sciences
Humans
Life Sciences
multidisciplinary
Nicotiana
Nucleotide Motifs
Placenta
Placenta - metabolism
Pregnancy
Science
Science (multidisciplinary)
Smoking
Smoking - adverse effects
ISSN:2041-1723, 2041-1723
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Shrnutí:Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium ( N  = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth. Maternal smoking during pregnancy contributes to poor birth outcomes. Here the authors perform a meta-analysis of the associations between maternal smoking during pregnancy and placental DNA methylation and identify links between these and poor birth outcomes, which may better inform the mechanisms through which smoking impacts placental function and fetal growth.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-24558-y