Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex

Homology-directed repair (HDR), a critical DNA repair pathway in mammalian cells, is complex, leading to multiple outcomes with different impacts on genomic integrity. However, the factors that control these different outcomes are often not well understood. Here we show that SWS1–SWSAP1-SPIDR contro...

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Veröffentlicht in:	Nature communications Jg. 12; H. 1; S. 4255 - 15
Hauptverfasser:	Prakash, Rohit, Sandoval, Thomas, Morati, Florian, Zagelbaum, Jennifer A., Lim, Pei-Xin, White, Travis, Taylor, Brett, Wang, Raymond, Desclos, Emilie C. B., Sullivan, Meghan R., Rein, Hayley L., Bernstein, Kara A., Krawczyk, Przemek M., Gautier, Jean, Modesti, Mauro, Vanoli, Fabio, Jasin, Maria
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 12.07.2021 Nature Publishing Group Nature Portfolio
Schlagworte:	13/106 13/109 13/31 45/100 45/41 631/337/1427/2122 631/337/149 82/83 Animals Bloom Syndrome - genetics Bloom Syndrome - pathology Bloom's syndrome Cancer Cell Proliferation Deoxyribonucleic acid DNA DNA damage DNA helicase DNA repair DNA-Binding Proteins - metabolism Embryos Genetics HEK293 Cells Heterozygosity Homologous recombination Homologous Recombination - genetics Homology Humanities and Social Sciences Humans Life Sciences Loss of heterozygosity Mammalian cells Meiosis Mice Mitosis Mouse Embryonic Stem Cells - metabolism multidisciplinary Multiprotein Complexes - metabolism Mutation Mutation - genetics Phenotype Proteins Rad51 Recombinase - metabolism Recombinase Repair Science Science (multidisciplinary) Sister Chromatid Exchange Survival Analysis Yeast DNA recombination Double-strand DNA breaks
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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