LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation

De novo DNA methylation (DNAme) during mouse oogenesis occurs within transcribed regions enriched for H3K36me3. As many oocyte transcripts originate in long terminal repeats (LTRs), which are heterogeneous even between closely related mammals, we examined whether species-specific LTR-initiated trans...

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Vydané v:	Nature communications Ročník 9; číslo 1; s. 3331 - 14
Hlavní autori:	Brind’Amour, Julie, Kobayashi, Hisato, Richard Albert, Julien, Shirane, Kenjiro, Sakashita, Akihiko, Kamio, Asuka, Bogutz, Aaron, Koike, Tasuku, Karimi, Mohammad M., Lefebvre, Louis, Kono, Tomohiro, Lorincz, Matthew C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 20.08.2018 Nature Publishing Group Nature Portfolio
Predmet:	38/15 38/39 38/91 631/136/2086 631/136/2434 631/208/176 631/208/182 64/60 64/86 Animals Blastocysts CpG islands CpG Islands - genetics Deoxyribonucleic acid Divergence DNA DNA methylation DNA Methylation - genetics DNA, Intergenic - genetics Epigenetics Fertilization - genetics Gene Expression Regulation Genomes Heredity Humanities and Social Sciences Humans Inheritance Patterns - genetics Life Sciences Mammals - metabolism Mice Mice, Inbred C57BL multidisciplinary Oocytes Oocytes - metabolism Oogenesis Placenta Polymorphism, Genetic Promoters Rats Retroelements - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Species Species Specificity Synteny Synteny - genetics Terminal Repeat Sequences - genetics Transcription Transcription, Genetic
ISSN:	2041-1723, 2041-1723
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Shrnutí:	De novo DNA methylation (DNAme) during mouse oogenesis occurs within transcribed regions enriched for H3K36me3. As many oocyte transcripts originate in long terminal repeats (LTRs), which are heterogeneous even between closely related mammals, we examined whether species-specific LTR-initiated transcription units (LITs) shape the oocyte methylome. Here we identify thousands of syntenic regions in mouse, rat, and human that show divergent DNAme associated with private LITs, many of which initiate in lineage-specific LTR retrotransposons. Furthermore, CpG island (CGI) promoters methylated in mouse and/or rat, but not human oocytes, are embedded within rodent-specific LITs and vice versa. Notably, at a subset of such CGI promoters, DNAme persists on the maternal genome in fertilized and parthenogenetic mouse blastocysts or in human placenta, indicative of species-specific epigenetic inheritance. Polymorphic LITs are also responsible for disparate DNAme at promoter CGIs in distantly related mouse strains, revealing that LITs also promote intra-species divergence in CGI DNAme. De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-018-05841-x