Absence of an embryonic stem cell DNA methylation signature in human cancer

Background Differentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate the proportion of cells in a mixture of cell types that are of fetal origin and a...

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Bibliographic Details
Published in:	BMC cancer Vol. 19; no. 1; pp. 711 - 12
Main Authors:	Zhang, Ze, Wiencke, John K., Koestler, Devin C., Salas, Lucas A., Christensen, Brock C., Kelsey, Karl T.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 19.07.2019 BioMed Central Ltd BMC
Subjects:	Adult Algorithms Analysis Biological markers Biomarkers Biomedical and Life Sciences Biomedicine Cancer Cancer Epigenomics Cancer genetics Cancer Research Cell differentiation Cell Plasticity Cellular Reprogramming - genetics CpG Islands DNA DNA methylation DNA Methylation - genetics Embryonic stem cells Epigenesis, Genetic Female Gene expression Genetic Heterogeneity Genetic Loci Genomes Genomics Health Promotion and Disease Prevention Human embryonic stem cells Human Embryonic Stem Cells - metabolism Humans Linear Models Male Medicine/Public Health Methylation Neoplasms - genetics Neoplasms - pathology Neoplastic Stem Cells - metabolism Oncology post-genomic analysis and emerging technologies Pregnancy Regression analysis Research Article Statistics, Nonparametric Stem cells Surgical Oncology Systems biology Transcriptome Tumors Human embryonic stem cells DNA methylation Biomarkers Cancer Epigenomics Cell differentiation
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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