Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Background In ovarian cancer, dysregulation of mRNA expression of several components of the family of the kallikrein-related peptidases (KLKs) is observed. In this study, we have analyzed the KLK5 mRNA expression pattern in tumor tissue of patients suffering from high-grade serous ovarian cancer sta...

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Bibliographic Details
Published in:	BMC cancer Vol. 19; no. 1; pp. 696 - 9
Main Authors:	Gong, Weiwei, Liu, Yueyang, Seidl, Christof, Diamandis, Eleftherios P., Kiechle, Marion, Drecoll, Enken, Kotzsch, Matthias, Magdolen, Viktor, Dorn, Julia
Format:	Journal Article
Language:	English
Published:	London BioMed Central 15.07.2019 BioMed Central Ltd BMC
Subjects:	Adult Aged Aged, 80 and over Antigens Ascites Biomarkers Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Ovarian Epithelial - pathology Chi-Square Distribution Development and progression Diagnosis Enzyme-linked immunosorbent assay Female Gene expression Genetic aspects Genomes Genomics Health aspects Health Promotion and Disease Prevention Humans Hydrolases Kallikrein Kallikreins - metabolism Kaplan-Meier Estimate KLK5 Medicine/Public Health Messenger RNA Middle Aged mRNA expression Neoplasm Staging Oncology Ovarian cancer Ovarian Neoplasms - pathology Polymerase chain reaction Progression-Free Survival Proportional Hazards Models Proteases Quantitative PCR Real-Time Polymerase Chain Reaction Regression analysis Research Article RNA RNA, Messenger - genetics Signaling peptides and proteins Statistics, Nonparametric Surgical Oncology Tumors Germany KLK5 Quantitative PCR Ovarian cancer mRNA expression
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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