Factors Associated With the Decline of C-Peptide in a Cohort of Young Children Diagnosed With Type 1 Diabetes

Abstract Context Understanding factors involved in the rate of C-peptide decline is needed to tailor therapies for type 1 diabetes (T1D). Objective Evaluate factors associated with rate of C-peptide decline after a T1D diagnosis in young children. Design Observational study. Setting Academic centers...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	The journal of clinical endocrinology and metabolism Ročník 106; číslo 3; s. e1380 - e1388
Hlavní autori:	Steck, Andrea K, Liu, Xiang, Krischer, Jeffrey P, Haller, Michael J, Veijola, Riitta, Lundgren, Markus, Ahmed, Simi, Akolkar, Beena, Toppari, Jorma, Hagopian, William A, Rewers, Marian J, Elding Larsson, Helena
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	US Oxford University Press 01.03.2021 Copyright Oxford University Press
Predmet:	Adolescent Age Age of Onset Alefacept Analysis Antithymocyte globulin Autoantibodies Autoantibodies - blood Autoimmunity Body mass index C-Peptide - blood Care and treatment Case-Control Studies Child Child, Preschool Children Clinical Medicine Clinical s Cohort Studies Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - epidemiology Diabetes therapy Diagnosis Disease Progression Down-Regulation Endocrinology and Diabetes Endokrinologi och diabetes Female Females Follow-Up Studies Health aspects Humans Infant Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Multivariate analysis Pediatrics Pediatrik Peptides Risk factors Sex Standard scores Type 1 diabetes Weight Florida Maryland Germany Finland pediatric type 1 diabetes risk factors new onset beta cell decline C-peptide
ISSN:	0021-972X, 1945-7197, 1945-7197
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Abstract Context Understanding factors involved in the rate of C-peptide decline is needed to tailor therapies for type 1 diabetes (T1D). Objective Evaluate factors associated with rate of C-peptide decline after a T1D diagnosis in young children. Design Observational study. Setting Academic centers. Participants A total of 57 participants from the Environmental Determinants of Diabetes in the Young (TEDDY) study who were enrolled at 3 months of age and followed until T1D, and 56 age-matched children diagnosed with T1D in the community. Intervention A mixed meal tolerance test was used to measure the area under the curve (AUC) C-peptide at 1, 3, 6, 12, and 24 months postdiagnosis. Outcome Factors associated with rate of C-peptide decline during the first 2 years postdiagnosis were evaluated using mixed effects models, adjusting for age at diagnosis and baseline C-peptide. Results Adjusted slopes of AUC C-peptide decline did not differ between TEDDY subjects and community controls (P = 0.21), although the former had higher C-peptide baseline levels. In univariate analyses combining both groups (n = 113), younger age, higher weight and body mass index z-scores, female sex, an increased number increased number of islet autoantibodies, and IA-2A or ZnT8A positivity at baseline were associated with a higher rate of C-peptide loss. Younger age, female sex, and higher weight z-score remained significant in multivariate analysis (all P < 0.02). At 3 months after diagnosis, higher HbA1c became an additional independent factor associated with a higher rate of C-peptide decline (P < 0.01). Conclusion Younger age at diagnosis, female sex, higher weight z-score, and HbA1c were associated with a higher rate of C-peptide decline after T1D diagnosis in young children.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3
ISSN:	0021-972X 1945-7197 1945-7197
DOI:	10.1210/clinem/dgaa715