Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
Highlights Extracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies. Multiplexing in EV biomarker development includes high-throughput screening as well as point-of-care testing platforms which to date have been applied mainly to EV su...
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| Published in: | Nano-micro letters Vol. 14; no. 1; pp. 3 - 36 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Singapore
Springer Nature Singapore
01.12.2022
Springer Nature B.V Springer Singapore SpringerOpen |
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| ISSN: | 2311-6706, 2150-5551, 2150-5551 |
| Online Access: | Get full text |
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| Abstract | Highlights
Extracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies.
Multiplexing in EV biomarker development includes high-throughput screening as well as point-of-care testing platforms which to date have been applied mainly to EV surface proteins or internal cargo miRNAs.
Multiplexed measurements at single-EV resolution are likely to revolutionize the applicability of EV analytes as biomarkers in complex and heterogeneous diseases.
Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency. |
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| AbstractList | Extracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies.Multiplexing in EV biomarker development includes high-throughput screening as well as point-of-care testing platforms which to date have been applied mainly to EV surface proteins or internal cargo miRNAs.Multiplexed measurements at single-EV resolution are likely to revolutionize the applicability of EV analytes as biomarkers in complex and heterogeneous diseases.
Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency. Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency. Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency.Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency. Highlights Extracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies. Multiplexing in EV biomarker development includes high-throughput screening as well as point-of-care testing platforms which to date have been applied mainly to EV surface proteins or internal cargo miRNAs. Multiplexed measurements at single-EV resolution are likely to revolutionize the applicability of EV analytes as biomarkers in complex and heterogeneous diseases. Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency. Abstract Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency. HighlightsExtracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies.Multiplexing in EV biomarker development includes high-throughput screening as well as point-of-care testing platforms which to date have been applied mainly to EV surface proteins or internal cargo miRNAs.Multiplexed measurements at single-EV resolution are likely to revolutionize the applicability of EV analytes as biomarkers in complex and heterogeneous diseases.Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency. |
| ArticleNumber | 3 |
| Author | Tofaris, George K. Fu, Ying Jiang, Cheng Davis, Jason Liu, Guozhen Shu, Bowen |
| Author_xml | – sequence: 1 givenname: Cheng surname: Jiang fullname: Jiang, Cheng email: cheng.jiang@ndcn.ox.ac.uk organization: Nuffield Department of Clinical Neurosciences, New Biochemistry Building, University of Oxford, Department of Chemistry, University of Oxford, Kavli Institute for Nanoscience Discovery, New Biochemistry Building, University of Oxford – sequence: 2 givenname: Ying surname: Fu fullname: Fu, Ying organization: Department of Chemistry, University of Oxford – sequence: 3 givenname: Guozhen surname: Liu fullname: Liu, Guozhen organization: School of Life and Health Sciences, The Chinese University of Hong Kong – sequence: 4 givenname: Bowen surname: Shu fullname: Shu, Bowen organization: Dermatology Hospital, Southern Medical University – sequence: 5 givenname: Jason surname: Davis fullname: Davis, Jason email: jason.davis@chem.ox.ac.uk organization: Department of Chemistry, University of Oxford – sequence: 6 givenname: George K. surname: Tofaris fullname: Tofaris, George K. email: george.tofaris@ndcn.ox.ac.uk organization: Nuffield Department of Clinical Neurosciences, New Biochemistry Building, University of Oxford, Kavli Institute for Nanoscience Discovery, New Biochemistry Building, University of Oxford |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34855021$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1146/annurev-cellbio-101512-122326 10.1039/C9AN02294E 10.1039/C2CC36111F 10.1016/j.bios.2018.06.018 10.1002/elan.201400557 10.1021/acs.analchem.0c01464 10.1109/TBME.2016.2601014 10.1016/j.tibtech.2019.04.005 10.1016/j.bios.2019.04.043 10.1002/smll.202004492 10.1021/acs.chemrev.7b00534 10.20517/evcna.2021.06 10.1016/j.jprot.2018.12.023 10.1016/j.aca.2021.338633 10.1038/s41551-016-0021 10.1039/c5lc01117e 10.1093/neuonc/noy187 10.1038/s41467-019-11486-1 10.1016/j.bios.2019.111565 10.1126/sciadv.aba2556 10.1021/acssensors.6b00256 10.1002/anie.201915046 10.1021/acs.analchem.6b05037 10.1021/jacs.9b13874 10.1002/anie.201703807 10.1021/ja0102639 10.1038/srep34358 10.1016/j.tibtech.2018.12.005 10.1016/j.bioelechem.2020.107532 10.1002/adfm.201910335 10.1021/acsnano.0c08165 10.1016/j.bios.2020.112222 10.1021/jacs.8b09422 10.1021/jacs.9b13960 10.1021/acs.chemrev.7b00668 10.1021/ac500931f 10.1039/C9AN02180A 10.1073/pnas.2011660117 10.1016/j.talanta.2010.09.023 10.1007/s40820-019-0285-x 10.1021/acsnano.7b07060 10.1021/acs.nanolett.9b02232 10.1002/acn3.175 10.1007/s00604-012-0894-2 10.1016/j.bios.2020.112520 10.1373/clinchem.2016.271049 10.3402/jev.v2i0.20920 10.1021/acs.chemrev.9b00739 10.1016/j.trac.2019.05.013 10.1007/s40820-020-00533-y 10.1021/acs.analchem.8b03959 10.1073/pnas.1814110116 10.3390/jcm10020319 10.1371/journal.pone.0198552 10.1016/j.ab.2011.09.004 10.3389/fbioe.2021.735711 10.1021/acs.analchem.8b03272 10.1016/j.lungcan.2017.12.012 10.1039/C2LC40727B 10.1208/s12248-018-0201-1 10.1016/j.jelechem.2016.11.043 10.1002/elps.200800425 10.1038/s42003-018-0179-3 10.1016/j.bios.2020.112292 10.1016/j.trecan.2020.09.003 10.1021/acssensors.9b00686 10.1073/pnas.1318602111 10.1021/acs.analchem.0c00106 10.1073/pnas.1408301111 10.3402/jev.v5.29975 10.1126/scitranslmed.aaz2878 10.1021/acs.analchem.0c03092 10.1016/j.celrep.2019.03.003 10.1021/ac401983w 10.1039/C9AN02485A 10.20517/evcna.2021.02 10.1002/anie.201811142 10.1002/mds.28591 10.1038/srep35928 10.1021/acsabm.1c00320 10.3389/fgene.2020.00258 10.1002/smll.201907521 10.1016/j.cclet.2021.09.058 10.1002/adbi.201900309 10.1038/s41427-019-0184-0 10.20517/evcna.2021.09 10.1016/j.jelechem.2016.01.031 10.1038/nnano.2011.44 10.1021/acssensors.9b02377 10.3233/JPD-171176 10.1002/adfm.201202073 10.1002/adma.201503223 10.1038/ncomms9797 10.1002/smll.202006230 10.1039/C5LC00036J 10.1021/acssensors.8b00365 10.1016/j.bios.2020.112506 10.1038/s41467-019-13242-x 10.1021/acs.analchem.8b00189 10.1002/smll.202007971 10.1016/j.matt.2019.10.018 10.1021/acsnano.9b09119 10.1038/s41565-021-00872-w 10.1002/smll.201903761 10.1021/nn501312q 10.1016/j.ab.2010.09.022 10.1016/j.aca.2013.02.005 10.1016/j.talanta.2018.02.083 10.1038/nm.3618 10.1002/smll.202008155 10.1039/C8CS00303C 10.1021/acsabm.9b00825 10.1002/advs.202102789 10.1039/C9TB01490J 10.1002/smll.201600725 10.1038/s41551-019-0356-9 10.1126/science.aaq0179 10.1039/C3CS60353A 10.1002/smtd.201800021 10.1016/j.tibtech.2017.03.013 10.1080/21691401.2018.1489263 10.7150/thno.21274 10.1007/s00216-011-5631-x 10.20517/evcna.2021.04 10.1002/smll.201903916 10.1021/acsphotonics.7b00992 10.1126/scitranslmed.aal3226 10.1016/j.bios.2021.113145 10.1021/acssensors.6b00532 10.1002/adbi.202000003 10.1007/s00401-014-1314-y 10.1038/s41467-019-09030-2 10.1039/D0NR00619J 10.1002/adma.201505022 10.1021/acs.analchem.0c01387 10.1002/mas.21420 10.1016/j.trac.2019.115767 10.1038/nature25456 10.1039/C8LC00386F 10.1021/acssensors.8b01047 10.1038/nrclinonc.2014.5 10.1016/j.bios.2021.113155 10.1021/acsanm.8b00267 10.1016/j.bios.2020.112835 10.1039/C9SC00961B 10.1039/C4LC00662C 10.1002/ange.201900092 10.1021/acsnano.1c00782 10.1016/j.tibtech.2018.08.005 10.1212/nxi.0000000000000866 10.20517/evcna.2021.07 10.1021/acs.nanolett.1c00715 10.1016/S0958-1669(02)00282-3 10.1021/acs.langmuir.5b04550 10.1002/anie.202000489 10.1021/ac5023056 10.3402/jev.v4.26048 10.1002/anie.201407982 10.1007/s40820-020-00583-2 10.1016/j.trac.2021.116200 10.1016/j.bios.2018.06.062 10.1039/C9AN00777F 10.7150/thno.21358 10.1016/j.bios.2017.11.033 10.1016/j.bios.2017.03.036 10.1016/j.bios.2015.09.061 10.1021/acsami.8b13971 10.1038/s41551-018-0343-6 10.1021/ac502082b 10.1007/s40820-020-0404-8 10.1021/jacs.0c12016 10.1002/VIW.20210003 10.1039/C2CS15267C 10.1039/D0AN00393J 10.1002/adom.202000162 10.1021/acsnano.7b05083 10.1002/anie.201809607 10.1021/acsnano.7b07782 10.1016/j.trac.2019.115773 10.1021/acsnano.0c07581 10.1002/anie.201603007 10.1039/C6MB00082G 10.1002/jev2.12025 10.1039/C7CS00172J 10.1021/acs.analchem.9b04852 10.1126/sciadv.aax3223 10.1126/sciadv.abc1204 10.1039/C6NR03478K 10.1038/srep37246 10.1038/nbt.2886 10.1038/nnano.2012.186 10.1016/j.trac.2021.116269 10.1002/smll.201502365 10.1136/jnnp-2019-322588 10.3389/fimmu.2018.01326 10.1039/C7NR09162A 10.1161/CIRCRESAHA.117.310752 10.1126/sciadv.1501645 10.1016/j.bios.2017.01.063 10.1038/nnano.2007.99 10.1038/s41586-020-2279-8 10.1007/s40820-021-00622-6 10.1038/srep12539 10.1016/j.bios.2016.06.058 10.1021/acsami.6b16108 10.1016/j.bios.2020.112056 10.1021/acsnano.5b07584 10.1016/j.tibtech.2019.04.012 10.1021/jacs.9b00007 10.1007/s40820-021-00613-7 10.1002/adbi.201900307 10.1371/journal.pone.0175050 10.1016/j.bios.2016.08.001 10.1093/annonc/mdx765 10.1002/VIW.20200148 10.1002/anie.202015628 10.1039/D0LC00431F 10.1002/anie.202005398 10.1101/2020.06.17.157180 10.1007/978-1-4939-6866-4_5 10.1109/SENSORS43011.2019.8956561 |
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| Keywords | Extracellular vesicles Liquid biopsy Biomarker Exosomes Point-of-care Multiplexed profiling |
| Language | English |
| License | 2021. The Author(s). Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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| OpenAccessLink | https://www.proquest.com/docview/2605423522?pq-origsite=%requestingapplication% |
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| PublicationCentury | 2000 |
| PublicationDate | 20221200 |
| PublicationDateYYYYMMDD | 2022-12-01 |
| PublicationDate_xml | – month: 12 year: 2022 text: 20221200 |
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| PublicationPlace | Singapore |
| PublicationPlace_xml | – name: Singapore – name: Germany – name: Heidelberg |
| PublicationTitle | Nano-micro letters |
| PublicationTitleAbbrev | Nano-Micro Lett |
| PublicationTitleAlternate | Nanomicro Lett |
| PublicationYear | 2022 |
| Publisher | Springer Nature Singapore Springer Nature B.V Springer Singapore SpringerOpen |
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| References | Shu, Lin, Wu, Huang, Wang (CR66) 2021; 181 Zhou, Wu, Hu, Yang, Chen (CR80) 2020; 6 Taufik, Barfidokht, Alam, Jiang, Parker (CR112) 2016; 779 Rica, Stevens (CR174) 2012; 7 Zhang, Ding, Xie, Ding, Huang (CR10) 2021; 2 Fu, Jiang, Tofaris, Davis (CR133) 2020; 92 Jara-Acevedo, Campos-Silva, Valés-Gómez, Yáñez-Mó, Suárez (CR161) 2019; 198 Guo, Xu, Estell, Ivory, Du (CR145) 2020; 164 Geng, Peveler, Rotello (CR190) 2019; 58 Bruch, Urban, Dincer (CR203) 2019; 37 Tian, Han, Deng, Liu, Sun (CR58) 2021 Tian, Ma, Gong, Su, Zhu (CR168) 2018; 12 Jiang, Alam, Parker, Darwish, Gooding (CR150) 2016; 32 Chan, Maxwell, Gao, Bailey, Han (CR169) 2002; 13 Krug, Enderle, Karlovich, Priewasser, Bentink (CR219) 2018; 29 Fang, Tian, Li, Jin, Li (CR48) 2017; 12 Shi, Liu, Cook, Bullock, Zhao (CR163) 2014; 128 Xu, Ye (CR19) 2020; 123 Mei, Fancy, Shen, Niu, Zhao (CR205) 2014; 20 Wu, Yu, Wu, Wu, Fan (CR114) 2021; 175 Zhou, Hu, Zhang, Tang, Li (CR100) 2020; 92 Liu, Xiong, Kwok, He, Lam (CR193) 2020; 8 Su, Jiang, Gou, Long (CR119) 2021; 4 Taton, Lu, Mirkin (CR172) 2001; 123 Zhang, Zhou, Zeng (CR99) 2019; 10 Park, Im, Hong, Castro, Weissleder (CR94) 2018; 5 Bai, Lu, Wang, Cheng, Qu (CR185) 2019; 11 Ji, Zhang, Ye, Ji, Dong (CR33) 2021; 9 Wang, Sun, Natalia, Tang, Ang (CR106) 2020; 2 Oliveira-Rodríguez, Serrano-Pertierra, García, López-Martín, Yañez-Mo (CR142) 2017; 87 Ko, Wang, Carlson, Marquard, Gungabeesoon (CR157) 2020; 4 Weckman, Ermann, Gutierrez, Chen, Graham (CR202) 2019; 4 Zhang, Jiang, Diefenbach, Campbell, Walsh (CR36) 2020; 5 Deng, Jiang, Jia (CR44) 2013; 771 Chen, Sun, Jiang (CR23) 2021; 13 Gootenberg, Abudayyeh, Kellner, Joung, Collins (CR199) 2018; 360 Zheng, Jiang, Ng, Lu, Han (CR32) 2016; 28 Park, Lin, Assaker, Jeong, Huang (CR129) 2017; 11 Chiu, Cai, Shih, Lian, Lo (CR90) 2016; 12 Mori, Hirase, Morishige, Takano, Sunayama (CR91) 2019; 58 Jang, Choi, Choi, Lee, Jung (CR105) 2019; 11 Jansen, Nickenig, Werner (CR17) 2017; 120 Taller, Richards, Slouka, Senapati, Hill (CR215) 2015; 15 Shin, Jeong, Park, Hong, Choi (CR35) 2018; 3 He, Crow, Roth, Zeng, Godwin (CR49) 2014; 14 Min, Son, Hong, Cheah, Wegemann (CR118) 2020; 4 Daaboul, Gagni, Benussi, Bettotti, Ciani (CR141) 2016; 6 Xiao, Hareendran, Loh (CR14) 2021; 2 Zhao, Yang, Zeng, He (CR43) 2016; 16 Koliha, Wiencek, Heider, Jüngst, Kladt (CR162) 2016; 5 Zhao, Liu, Li, Ma, Deng (CR70) 2020; 142 Yaraki, Wu, Middha, Wu, Rezaei (CR194) 2021; 13 CR135 Liu, Zhao, Tian, Cai, Zhang (CR57) 2019; 3 Jeong, Park, Pathania, Castro, Weissleder (CR92) 2016; 10 Yang, Rhee (CR76) 2021; 10 Jiang, Xu, Zhang, Jia (CR153) 2012; 420 Chin, Son, Hong, Liu, Skog (CR120) 2020; 14 Jha, Chand, Han, Jang, Ra (CR156) 2012; 12 Khan, Zhu, Yao, Zhang, Agrawal (CR110) 2020; 12 Min, Wang, Bao, Li, Zhao (CR222) 2021; 8 Nakamura, Kaneko, Villemagne, Kato, Doecke (CR21) 2018; 554 Ghassemi, Wang, Wang, Wang, Chen (CR83) 2017; 64 Yang, Liu, Jiang (CR189) 2019; 48 Zhu, Wang, Cui, Liu, Bu (CR96) 2014; 86 Tian, Liu, Lin, Chen, Sun (CR128) 2019; 117 Abramowicz, Widlak, Pietrowska (CR27) 2016; 12 Hu, Wolfram, Srivastava (CR7) 2021; 7 Huang, Mousavi, Zhao, Hubarevich, Omeis (CR115) 2019; 10 Cheng, Lowe, Reece, Gooding (CR170) 2014; 43 Zhou, Mohamadi, Poudineh, Kermanshah, Ahmed (CR179) 2016; 12 Ackerman, Myhrvold, Thakku, Freije, Metsky (CR201) 2020; 582 Cheng, Fu, Kuo, Chen, Chen (CR103) 2018; 18 Wu, Kwak, Agarwal, Marras, Wang (CR81) 2013; 85 Olcum, Cermak, Wasserman, Christine, Atsumi (CR139) 2014; 111 Soda, Rehm, Sonar, Nguyen, Shiddiky (CR186) 2019; 7 Wang, Chen, Huang, Li, Deng (CR53) 2018; 184 Kwizera, O'Connor, Vinduska, Williams, Butch (CR95) 2018; 8 Vacchi, Burrello, Di Silvestre, Burrello, Bolis (CR165) 2020; 7 Wei, Ni, Cao, Yang, Liu (CR181) 2018; 3 Liu, Li, Wu, Xing, Lai (CR87) 2018; 102 Tian, Shu, Jiang, Ye, Liu (CR67) 2021; 15 Choi, Kim, Kim, Gho (CR28) 2015; 34 Lim, Natalia, Sundah, Shao (CR213) 2020; 4 Cialla-May, Zheng, Weber, Popp (CR42) 2017; 46 Wang, Zong, Wang, Li, Li (CR37) 2018; 10 Yeh, Fu, Hu, Thakur, Feng (CR64) 2017; 3 Tang, Vaze, Shen, Rusling (CR130) 2016; 1 Liu, Jiang, Lin, Yang (CR73) 2021; 2 Jiang, Hopfner, Katsikoudi, Hein, Catli (CR93) 2020; 91 Xu, Liao, Zuo, Liu, Ye (CR127) 2018; 90 Zhang, Shi, Zhang, Zhu, Liu (CR62) 2020; 10 Song, Chen, Kuang, Yao, Tang (CR154) 2021; 139 Zhou, Zou, Sun, Ren, Chen (CR122) 2018; 117 CR214 Wang, Zeng, Crunteanu, Xie, Humbert (CR34) 2021; 13 Wan, Zhou, Poudineh, Safaei, Mohamadi (CR180) 2014; 53 Zhu, Ji, Deng, Li, Bai (CR216) 2021 Guo, Ding, Gu, Liu, Jiang (CR183) 2018; 140 Dincer, Bruch, Kling, Dittrich, Urban (CR210) 2017; 35 You, Miranda, Gider, Ghosh, Kim (CR191) 2007; 2 Dai, Wu, Liu, Gooding (CR198) 2020; 59 Wang, He, Wan, Sheng, Cheng (CR104) 2020; 145 Goda, Masuno, Nishida, Kosaka, Ochiya (CR131) 2012; 48 Zhou, Yang, Wu, Liu (CR20) 2021; 1175 Aoki, Corn, Matthews (CR121) 2019; 142 Tomlinson, Zheng, Fischer, Heidasch, Gardiner (CR11) 2015; 2 Huang, Mousavi, Giovannini, Zhao, Hubarevich (CR116) 2020; 59 Vaidyanathan, Naghibosadat, Rauf, Korbie, Carrascosa (CR84) 2014; 86 Wang, Khan, Huang, Ye, Di (CR50) 2020; 154 Yang, Kannisto, Yu, Reid, Patnaik (CR79) 2018; 10 Jiang, Wang, Hein, Liu, Luo (CR113) 2020; 120 Lv, Ye, Yuan, Liu, Chen (CR184) 2020; 123 Kaur, Jiang, Liu (CR211) 2019; 123 Zhou, Hu, Han, Wu, Hua (CR77) 2020; 16 Ning, Wang, Tian, Yin, Ye (CR38) 2020; 145 An, Li, Zhang, He (CR101) 2020; 92 Zhang, Jiang, Jia (CR152) 2011; 408 Ragni, Orfei, Papait, Girolamo (CR4) 2021; 2 Jørgensen, Bæk, Pedersen, Søndergaard, Kristensen (CR123) 2013; 2 Fan, Xiao, Lin, Liao, Huang (CR8) 2019; 15 Zhao, Xie, Gu, Zhu, Gu (CR178) 2012; 41 Wu, Zhao, Natalia, Lim, Ho (CR63) 2020; 6 Li, Liu, Pan, Shen, Guo (CR54) 2020; 168 Wiklander, Bostancioglu, Welsh, Zickler, Murke (CR164) 2018; 9 Takeuchi, Mori, Sunayama, Takano, Kitayama (CR98) 2020; 142 Xiong, Huang, Yang, Lin, Yang (CR5) 2021; 17 Arlett, Myers, Roukes (CR138) 2011; 6 Wang, Kwak, Yang, Zhang, Zhang (CR82) 2018; 13 Riordon, Sovilj, Sanner, Sinton, Young (CR221) 2019; 37 Tamura, Yoshioka, Sakamoto, Ichikawa, Ochiya (CR9) 2021; 2 Zhang, Zhou, He, Shang, Tetlow (CR207) 2019; 3 Gaňová, Zhang, Zhu, Korabečná, Neužil (CR160) 2021; 181 Tofaris (CR13) 2017; 7 Singh, Huang, Wang, Shao, Zhang (CR155) 2020; 92 CR204 Li, Li, Wang, Liu (CR195) 2019; 37 Huang, Lin, Zhu, Duan, Jin (CR40) 2020; 20 Li, Liu, Liu (CR196) 2019; 37 Wu, Li, Ding, Xu, Ma (CR29) 2020; 12 Jiang, Silva, Fan, Wu, Alam (CR134) 2017; 785 Rupert, Lässer, Eldh, Block, Zhdanov (CR107) 2014; 86 Gool, Stojanovic, Schasfoort, Sturk, Leeuwen (CR109) 2017; 63 Guan, Jiang, Hu, Jia (CR45) 2010; 83 Zong, Xu, Xu, Wei, Ma (CR30) 2018; 118 Dong, Tang, Zhang, Zhou, Zhao (CR212) 2020; 3 Chevillet, Kang, Ruf, Briggs, Vojtech (CR72) 2014; 111 Liu, Yang, Wu (CR111) 2018; 20 Lee, Fraser, Ghaddar, Yang, Kim (CR51) 2018; 12 Im, Shao, Park, Peterson, Castro (CR86) 2014; 32 Loh (CR2) 2021; 2 Cavallaro, Pevere, Stridfeldt, Görgens, Paba (CR52) 2021; 17 Zhao, Wijerathne, Godwin, Soper (CR26) 2021; 2 Wu, Yan, Shen, Sun, Thulin (CR60) 2019; 10 Guo, Wang, Chen, Wei, Fu (CR187) 2020; 16 Shirshahi, Liu (CR146) 2021; 136 Ziaei, Berkman, Norton (CR25) 2018; 1 Xia, Liu, Wang, Yan, He (CR55) 2017; 92 Rodrigues, Richards, Ning, Lyon, Hu (CR97) 2019; 19 Cao, Zhang, Jiang, Qi, Liu (CR218) 2017; 9 Jin, Yang, Zhang, Liu, Zhou (CR56) 2018; 90 Xu, Jiang, Lin, Jia (CR47) 2012; 179 Shin, Oh, Hong, Kang, Kang (CR220) 2020; 14 Cui, Cheng, Qin, Jiang (CR6) 2018; 116 Jiang, Shi, Liu, Wan, Cui (CR88) 2017; 56 Liu, Zhao, Tian, Chang, Zhang (CR85) 2019; 141 Lyu, Cui, Huang, Fan, Miao (CR89) 2019; 58 Lin, Tian, Lu, Liu, Huang (CR59) 2021; 60 Zaborowski, Lee, Na, Sammarco, Zhang (CR124) 2019; 27 Ko, Wang, Sheng, Weitz, Weissleder (CR159) 2021; 15 Cheng, Hinde, Owen, Lowe, Reece (CR171) 2015; 27 Jiang, Alam, Parker, Gooding (CR136) 2015; 27 Cialla, März, Böhme, Theil, Weber (CR41) 2012; 403 Yang, Im, Hong, Pergolini, Castillo (CR102) 2017; 9 CR197 Bian, Sun, Cai, Wang, Zhao (CR188) 2020; 117 Noto, Bugatti, Zendrini, Mazzoldi, Montanelli (CR173) 2016; 77 Schwarzenbach, Nishida, Calin, Pantel (CR71) 2014; 11 Colombo, Raposo, Théry (CR1) 2014; 3 Zhang, Li, Jin, Jiang, Lu (CR151) 2015; 5 Zheng, Thai, Reineck, Qiu, Guo (CR176) 2013; 23 Ma, Zhu, Tian, Zhang, Wang (CR167) 2016; 128 Fan, Yu, Lin, Liu, Liao (CR3) 2019; 144 Pan, Zhang, Natalia, Lim, Ho (CR117) 2021; 16 Luo, Lv, Zhu, Li, Wang (CR149) 2020; 59 Fraser, Jo, Giedt, Vinegoni, Yang (CR223) 2019; 21 Daaboul, Lopez, Chinnala, Goldberg, Connor (CR143) 2014; 8 Jiang, Alam, Silva, Taufik, Fan (CR132) 2016; 1 Zhang, Wu, Gardashova, Yang, Zhang (CR206) 2020; 12 Plou, García, Charconnet, Astobiza, García-Astrain (CR31) 2020; 30 Wang, Wuethrich, Sina, Lane, Lin (CR39) 2020; 6 Yelleswarapu, Buser, Haber, Baron, Inapuri (CR65) 2019; 116 Tian, He, Liu, Zhao, Hui (CR158) 2018; 90 Li, Deng, Han, Liu, Tian (CR69) 2021; 143 Yu, Xianyu (CR192) 2021; 17 Baharfar, Rahbar, Tajik, Liu (CR147) 2020; 167 Liu, Yang, Liu (CR148) 2019; 136 Lim, Zhang, Chen, Zhao, Stephenson (CR68) 2019; 10 Zheng, Soeriyadi, Rosa, Ng, Bach (CR175) 2015; 6 Orooji, Sohrabi, Hemmat, Oroojalian, Baradaran (CR217) 2020; 13 Etayash, McGee, Kaur, Thundat (CR140) 2016; 8 Thakur, Qiu, Ng, Guan, Yue (CR108) 2017; 94 Gebauer, Malá, Boček (CR144) 2009; 30 Shao, Im, Castro, Breakefield, Weissleder (CR18) 2018; 118 Liu, Kannisto, Yu, Yang, Reid (CR78) 2020; 11 Liang, Liu, Fan, Sun, Liu (CR177) 2017; 1 Jin, Peng, Qin, Wu, Lu (CR22) 2020; 92 Xu, Shoaei, Jahanpeyma, Zhao, Azimzadeh (CR126) 2020; 161 Marcoux, Duchez, Cloutier, Provost, Nigrovic (CR166) 2016; 6 Zhao, Tian, Huang, Liu, Dong (CR209) 2020; 145 Jiang, Hopfner, Berg, Hu, Pilotto (CR15) 2021 Lin, Yu, Chen, Wang, Miao (CR46) 2020; 16 Bei, Das, Rodosthenous, Holvoet, Vanhaverbeke (CR16) 2017; 7 Lee, Kwon, Kim, Rhee (CR75) 2018; 46 Shen, Huang, Wei, Niu, Li (CR182) 2020; 134 Huang, Tian, Zhao, Liu, Ma (CR208) 2020; 145 Zhang, Jin, Gao, Zhang, Li (CR24) 2018; 2 Jørgensen, Bæk, Varming (CR125) 2015; 4 Patil, Al-Jehani, Etayash, Turbe, Jiang (CR137) 2018; 1 Lee, Kim, Jeong, Rhee (CR74) 2016; 86 Li, Tofaris, Davis (CR12) 2017; 89 Löf, Ebai, Dubois, Wik, Ronquist (CR61) 2016; 6 Yue, Shu, Tian, Xiong, Huang (CR200) 2021; 21 L Xu (753_CR126) 2020; 161 GG Daaboul (753_CR143) 2014; 8 N Koliha (753_CR162) 2016; 5 Y Li (753_CR196) 2019; 37 Z Zhao (753_CR43) 2016; 16 W Zhang (753_CR36) 2020; 5 L Xiao (753_CR14) 2021; 2 H Xu (753_CR19) 2020; 123 L Huang (753_CR208) 2020; 145 M Jang (753_CR105) 2019; 11 TA Taton (753_CR172) 2001; 123 EC Yeh (753_CR64) 2017; 3 Y Jiang (753_CR88) 2017; 56 N Singh (753_CR155) 2020; 92 Y Li (753_CR195) 2019; 37 Y Wu (753_CR81) 2013; 85 F Zhu (753_CR216) 2021 H Xiong (753_CR5) 2021; 17 X Cheng (753_CR170) 2014; 43 J Zhang (753_CR62) 2020; 10 D Taller (753_CR215) 2015; 15 H Wang (753_CR53) 2018; 184 Y Fu (753_CR133) 2020; 92 Y Bei (753_CR16) 2017; 7 Z Shen (753_CR182) 2020; 134 V Shirshahi (753_CR146) 2021; 136 C Jiang (753_CR150) 2016; 32 T Tamura (753_CR9) 2021; 2 CK Tang (753_CR130) 2016; 1 P Zhang (753_CR207) 2019; 3 J Wang (753_CR39) 2020; 6 H Shao (753_CR18) 2018; 118 C Jiang (753_CR93) 2020; 91 J Zhao (753_CR70) 2020; 142 M Rodrigues (753_CR97) 2019; 19 DS Choi (753_CR28) 2015; 34 S Guo (753_CR145) 2020; 164 A Abramowicz (753_CR27) 2016; 12 B Lin (753_CR59) 2021; 60 Q Chen (753_CR23) 2021; 13 J Riordon (753_CR221) 2019; 37 S Zhou (753_CR20) 2021; 1175 Y Zhang (753_CR10) 2021; 2 Q Guo (753_CR187) 2020; 16 M Yang (753_CR189) 2019; 48 Z Luo (753_CR149) 2020; 59 CC You (753_CR191) 2007; 2 G Liu (753_CR73) 2021; 2 W Liu (753_CR87) 2018; 102 F Jansen (753_CR17) 2017; 120 A Krug (753_CR219) 2018; 29 J Park (753_CR94) 2018; 5 J Ko (753_CR157) 2020; 4 Y Zheng (753_CR176) 2013; 23 J Kaur (753_CR211) 2019; 123 X Zhang (753_CR151) 2015; 5 F Tian (753_CR58) 2021 JA Huang (753_CR116) 2020; 59 MA Khan (753_CR110) 2020; 12 Y Tian (753_CR168) 2018; 12 X Wu (753_CR63) 2020; 6 D Cialla-May (753_CR42) 2017; 46 OPB Wiklander (753_CR164) 2018; 9 B Li (753_CR54) 2020; 168 S Cui (753_CR6) 2018; 116 C Jiang (753_CR15) 2021 M Gaňová (753_CR160) 2021; 181 JL Arlett (753_CR138) 2011; 6 L Löf (753_CR61) 2016; 6 753_CR197 P Zhang (753_CR206) 2020; 12 Z Fan (753_CR8) 2019; 15 H Wang (753_CR104) 2020; 145 R Jara-Acevedo (753_CR161) 2019; 198 H Yue (753_CR200) 2021; 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117 F Mei (753_CR205) 2014; 20 C Jiang (753_CR132) 2016; 1 YJ Chiu (753_CR90) 2016; 12 Y Orooji (753_CR217) 2020; 13 S Cavallaro (753_CR52) 2021; 17 G Huang (753_CR40) 2020; 20 C Jiang (753_CR136) 2015; 27 W Zhao (753_CR209) 2020; 145 S Zhou (753_CR100) 2020; 92 P Ziaei (753_CR25) 2018; 1 V Yelleswarapu (753_CR65) 2019; 116 M Jørgensen (753_CR123) 2013; 2 Q Tian (753_CR158) 2018; 90 G Marcoux (753_CR166) 2016; 6 C Zhou (753_CR122) 2018; 117 SB Patil (753_CR137) 2018; 1 MM Jørgensen (753_CR125) 2015; 4 S Wang (753_CR50) 2020; 154 Q Su (753_CR119) 2021; 4 D Jin (753_CR22) 2020; 92 Z Wang (753_CR106) 2020; 2 M Oliveira-Rodríguez (753_CR142) 2017; 87 C Liu (753_CR85) 2019; 141 A Nakamura (753_CR21) 2018; 554 L Min (753_CR222) 2021; 8 C Song (753_CR154) 2021; 139 R Rica (753_CR174) 2012; 7 M Shi (753_CR163) 2014; 128 N Soda (753_CR186) 2019; 7 H Aoki (753_CR121) 2019; 142 E Vacchi (753_CR165) 2020; 7 HC Yang (753_CR76) 2021; 10 D Jin (753_CR56) 2018; 90 A Thakur (753_CR108) 2017; 94 753_CR135 W Guo (753_CR183) 2018; 140 L Ma (753_CR167) 2016; 128 S Olcum (753_CR139) 2014; 111 |
| References_xml | – volume: 3 start-page: 255 year: 2014 end-page: 289 ident: CR1 article-title: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev-cellbio-101512-122326 – volume: 145 start-page: 2873 issue: 8 year: 2020 end-page: 2891 ident: CR209 article-title: A smartphone-based biomedical sensory system publication-title: Analyst doi: 10.1039/C9AN02294E – volume: 48 start-page: 11942 issue: 98 year: 2012 end-page: 11944 ident: CR131 article-title: A label-free electrical detection of exosomal micrornas using microelectrode array publication-title: Chem. Comm. doi: 10.1039/C2CC36111F – volume: 123 start-page: 85 issue: 1 year: 2019 end-page: 100 ident: CR211 article-title: Different strategies for detection of HBA1C emphasizing on biosensors and point-of-care analyzers publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2018.06.018 – volume: 27 start-page: 884 issue: 4 year: 2015 end-page: 889 ident: CR136 article-title: Zwitterionic phenyl phosphorylcholine on indium tin oxide: a low-impedance protein-resistant platform for biosensing publication-title: Electroanalysis doi: 10.1002/elan.201400557 – volume: 92 start-page: 10569 issue: 15 year: 2020 end-page: 10577 ident: CR155 article-title: Simultaneous detection of a cluster of differentiation markers on leukemia-derived exosomes by multiplex immuno-polymerase chain reaction via capillary electrophoresis analysis publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c01464 – volume: 64 start-page: 1650 issue: 7 year: 2017 end-page: 1653 ident: CR83 article-title: Evaluation of mobile phone performance for near-infrared fluorescence imaging publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2016.2601014 – volume: 37 start-page: 791 issue: 8 year: 2019 end-page: 792 ident: CR203 article-title: Crispr/Cas powered multiplexed biosensing publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2019.04.005 – volume: 136 start-page: 60 year: 2019 end-page: 75 ident: CR148 article-title: Signal amplification strategies for paper-based analytical devices publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2019.04.043 – volume: 16 start-page: 2004492 issue: 48 year: 2020 ident: CR77 article-title: Accurate cancer diagnosis and stage monitoring enabled by comprehensive profiling of different types of exosomal biomarkers: surface proteins and miRNAs publication-title: Small doi: 10.1002/smll.202004492 – volume: 118 start-page: 1917 issue: 4 year: 2018 end-page: 1950 ident: CR18 article-title: New technologies for analysis of extracellular vesicles publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.7b00534 – volume: 2 start-page: 148 issue: 2 year: 2021 end-page: 174 ident: CR9 article-title: Extracellular vesicles as a promising biomarker resource in liquid biopsy for cancer publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.06 – volume: 198 start-page: 87 year: 2019 end-page: 97 ident: CR161 article-title: Exosome beads array for multiplexed phenotyping in cancer publication-title: J. Proteomics doi: 10.1016/j.jprot.2018.12.023 – volume: 1175 year: 2021 ident: CR20 article-title: Review: multiplexed profiling of biomarkers in extracellular vesicles for cancer diagnosis and therapy monitoring publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2021.338633 – volume: 1 start-page: 0021 issue: 4 year: 2017 ident: CR177 article-title: Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-016-0021 – volume: 16 start-page: 489 issue: 3 year: 2016 end-page: 496 ident: CR43 article-title: A microfluidic Exosearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis publication-title: Lab Chip doi: 10.1039/c5lc01117e – volume: 21 start-page: 606 issue: 5 year: 2019 end-page: 615 ident: CR223 article-title: Characterization of single microvesicles in plasma from glioblastoma patients publication-title: Neuro Oncol. doi: 10.1093/neuonc/noy187 – volume: 10 start-page: 3854 issue: 1 year: 2019 ident: CR60 article-title: Profiling surface proteins on individual exosomes using a proximity barcoding assay publication-title: Nat. Comm. doi: 10.1038/s41467-019-11486-1 – volume: 142 year: 2019 ident: CR121 article-title: Microrna detection on microsensor arrays by SPR imaging measurements with enzymatic signal enhancement publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2019.111565 – volume: 6 start-page: 2556 issue: 19 year: 2020 ident: CR63 article-title: Exosome-templated nanoplasmonics for multiparametric molecular profiling publication-title: Sci. Adv. doi: 10.1126/sciadv.aba2556 – volume: 1 start-page: 1036 issue: 8 year: 2016 end-page: 1043 ident: CR130 article-title: High-throughput electrochemical microfluidic immunoarray for multiplexed detection of cancer biomarker proteins publication-title: ACS Sens. doi: 10.1021/acssensors.6b00256 – volume: 59 start-page: 3131 issue: 8 year: 2020 end-page: 3136 ident: CR149 article-title: Paper-based ratiometric fluorescence analytical devices towards point-of-care testing of human serum albumin publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201915046 – volume: 89 start-page: 3184 issue: 5 year: 2017 end-page: 3190 ident: CR12 article-title: Concentration-normalized electroanalytical assaying of exosomal markers publication-title: Anal. Chem. doi: 10.1021/acs.analchem.6b05037 – volume: 142 start-page: 6617 issue: 14 year: 2020 end-page: 6624 ident: CR98 article-title: Antibody-conjugated signaling nanocavities fabricated by dynamic molding for detecting cancers using small extracellular vesicle markers from tears publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b13874 – volume: 56 start-page: 11916 issue: 39 year: 2017 end-page: 11920 ident: CR88 article-title: Aptamer/AuNP biosensor for colorimetric profiling of exosomal proteins publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201703807 – volume: 123 start-page: 5164 issue: 21 year: 2001 end-page: 5165 ident: CR172 article-title: Two-color labeling of oligonucleotide arrays via size-selective scattering of nanoparticle probes publication-title: J. Am. Chem. Soc. doi: 10.1021/ja0102639 – volume: 6 start-page: 34358 year: 2016 ident: CR61 article-title: Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout publication-title: Sci. Rep. doi: 10.1038/srep34358 – volume: 37 start-page: 730 issue: 7 year: 2019 end-page: 743 ident: CR195 article-title: Crispr/cas systems towards next-generation biosensing publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2018.12.005 – volume: 134 year: 2020 ident: CR182 article-title: Validation of an in vivo electrochemical immunosensing platform for simultaneous detection of multiple cytokines in Parkinson’s disease mice model publication-title: Bioelectrochemistry doi: 10.1016/j.bioelechem.2020.107532 – volume: 30 start-page: 1910335 issue: 17 year: 2020 ident: CR31 article-title: Multiplex SERS detection of metabolic alterations in tumor extracellular media publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201910335 – volume: 15 start-page: 1167 issue: 1 year: 2021 end-page: 1178 ident: CR67 article-title: An ultralocalized cas13a assay enables universal and nucleic acid amplification-free single-molecule RNA diagnostics publication-title: ACS Nano doi: 10.1021/acsnano.0c08165 – volume: 161 year: 2020 ident: CR126 article-title: Optical, electrochemical and electrical (Nano) biosensors for detection of exosomes: a comprehensive overview publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112222 – volume: 140 start-page: 15904 issue: 46 year: 2018 end-page: 15915 ident: CR183 article-title: Potential-resolved multicolor electrochemiluminescence for multiplex immunoassay in a single sample publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b09422 – volume: 142 start-page: 4996 issue: 11 year: 2020 end-page: 5001 ident: CR70 article-title: Thermophoretic detection of exosomal microRNAs by nanoflares publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b13960 – volume: 118 start-page: 4946 issue: 10 year: 2018 end-page: 4980 ident: CR30 article-title: Surface-enhanced Raman spectroscopy for bioanalysis: reliability and challenges publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.7b00668 – volume: 86 start-page: 5929 issue: 12 year: 2014 end-page: 5936 ident: CR107 article-title: Determination of exosome concentration in solution using surface plasmon resonance spectroscopy publication-title: Anal. Chem. doi: 10.1021/ac500931f – volume: 145 start-page: 2795 issue: 7 year: 2020 end-page: 2804 ident: CR38 article-title: Multiple and sensitive SERS detection of cancer-related exosomes based on gold–silver bimetallic nanotrepangs publication-title: Analyst doi: 10.1039/C9AN02180A – volume: 117 start-page: 22736 issue: 37 year: 2020 end-page: 22742 ident: CR188 article-title: Bioinspired Mxene-integrated colloidal crystal arrays for multichannel bioinformation coding publication-title: PNAS doi: 10.1073/pnas.2011660117 – volume: 83 start-page: 337 issue: 2 year: 2010 end-page: 343 ident: CR45 article-title: Preparation of multi-walled carbon nanotubes functionalized magnetic particles by sol-gel technology and its application in extraction of estrogens publication-title: Talanta doi: 10.1016/j.talanta.2010.09.023 – volume: 11 start-page: 59 year: 2019 ident: CR185 article-title: Rapid isolation and multiplexed detection of exosome tumor markers via queued beads combined with quantum dots in a microarray publication-title: Nano-Micro Lett. doi: 10.1007/s40820-019-0285-x – volume: 12 start-page: 494 issue: 1 year: 2018 end-page: 503 ident: CR51 article-title: Multiplexed profiling of single extracellular vesicles publication-title: ACS Nano doi: 10.1021/acsnano.7b07060 – volume: 19 start-page: 7623 issue: 11 year: 2019 end-page: 7631 ident: CR97 article-title: Rapid lipid-based approach for normalization of quantum-dot-detected biomarker expression on extracellular vesicles in complex biological samples publication-title: Nano Lett. doi: 10.1021/acs.nanolett.9b02232 – volume: 2 start-page: 353 issue: 4 year: 2015 end-page: 361 ident: CR11 article-title: Identification of distinct circulating exosomes in Parkinson's disease publication-title: Ann. Clin. Transl. Neurol. doi: 10.1002/acn3.175 – volume: 179 start-page: 257 issue: 3 year: 2012 end-page: 264 ident: CR47 article-title: Magnetic nanoparticles modified with polydimethylsiloxane and multi-walled carbon nanotubes for solid-phase extraction of fluoroquinolones publication-title: Microchim. Acta doi: 10.1007/s00604-012-0894-2 – volume: 168 year: 2020 ident: CR54 article-title: Facile fluorescent aptasensor using aggregation-induced emission luminogens for exosomal proteins profiling towards liquid biopsy publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112520 – volume: 63 start-page: 1633 issue: 10 year: 2017 end-page: 1641 ident: CR109 article-title: Surface plasmon resonance is an analytically sensitive method for antigen profiling of extracellular vesicles publication-title: Clin. Chem. doi: 10.1373/clinchem.2016.271049 – volume: 2 start-page: 20920 issue: 1 year: 2013 ident: CR123 article-title: Extracellular vesicle (EV) array: microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping publication-title: J. Extracell. Vesicles doi: 10.3402/jev.v2i0.20920 – volume: 120 start-page: 3852 issue: 8 year: 2020 end-page: 3889 ident: CR113 article-title: Antifouling strategies for selective in vitro and in vivo sensing publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.9b00739 – volume: 117 start-page: 128 year: 2019 end-page: 145 ident: CR128 article-title: Microfluidic analysis of circulating tumor cells and tumor-derived extracellular vesicles publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2019.05.013 – volume: 13 start-page: 18 year: 2020 ident: CR217 article-title: An overview on SARS-Cov-2 (COVID-19) and other human coronaviruses and their detection capability via amplification assay, chemical sensing, biosensing, immunosensing, and clinical assays publication-title: Nano-Micro Lett. doi: 10.1007/s40820-020-00533-y – volume: 90 start-page: 14402 issue: 24 year: 2018 end-page: 14411 ident: CR56 article-title: ExoAPP: exosome-oriented, aptamer nanoprobe-enabled surface proteins profiling and detection publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b03959 – volume: 116 start-page: 4489 issue: 10 year: 2019 end-page: 4495 ident: CR65 article-title: Mobile platform for rapid sub–picogram-per-milliliter, multiplexed, digital droplet detection of proteins publication-title: PNAS doi: 10.1073/pnas.1814110116 – volume: 10 start-page: 319 issue: 2 year: 2021 ident: CR76 article-title: Single step in situ detection of surface protein and microRNA in clustered extracellular vesicles using flow cytometry publication-title: J. Clin. Med. doi: 10.3390/jcm10020319 – volume: 13 issue: 6 year: 2018 ident: CR82 article-title: Extracellular mRNA detected by molecular beacons in tethered lipoplex nanoparticles for diagnosis of human hepatocellular carcinoma publication-title: PLoS ONE doi: 10.1371/journal.pone.0198552 – volume: 420 start-page: 20 issue: 1 year: 2012 end-page: 25 ident: CR153 article-title: Chitosan functionalized magnetic particle-assisted detection of genetically modified soybeans based on polymerase chain reaction and capillary electrophoresis publication-title: Anal. Biochem. doi: 10.1016/j.ab.2011.09.004 – volume: 9 issue: 787 year: 2021 ident: CR33 article-title: Magnetically enhanced liquid SERS for ultrasensitive analysis of bacterial and SARS-Cov-2 biomarkers publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2021.735711 – volume: 90 start-page: 13451 issue: 22 year: 2018 end-page: 13458 ident: CR127 article-title: Magnetic-based microfluidic device for on-chip isolation and detection of tumor-derived exosomes publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b03272 – volume: 116 start-page: 46 year: 2018 end-page: 54 ident: CR6 article-title: Exosomes as a liquid biopsy for lung cancer publication-title: Lung Cancer doi: 10.1016/j.lungcan.2017.12.012 – volume: 12 start-page: 4455 issue: 21 year: 2012 end-page: 4464 ident: CR156 article-title: An integrated PCR microfluidic chip incorporating aseptic electrochemical cell lysis and capillary electrophoresis amperometric DNA detection for rapid and quantitative genetic analysis publication-title: Lab Chip doi: 10.1039/C2LC40727B – volume: 20 start-page: 41 issue: 2 year: 2018 ident: CR111 article-title: Recent advances in exosomal protein detection via liquid biopsy biosensors for cancer screening, diagnosis, and prognosis publication-title: AAPS J. doi: 10.1208/s12248-018-0201-1 – volume: 785 start-page: 265 year: 2017 end-page: 278 ident: CR134 article-title: Aryldiazonium salt derived mixed organic layers: from surface chemistry to their applications publication-title: J. Electroanal. Chem. doi: 10.1016/j.jelechem.2016.11.043 – volume: 30 start-page: 29 issue: 1 year: 2009 end-page: 35 ident: CR144 article-title: Recent progress in analytical capillary ITP publication-title: Electrophoresis doi: 10.1002/elps.200800425 – volume: 1 start-page: 175 issue: 1 year: 2018 ident: CR137 article-title: Modified cantilever arrays improve sensitivity and reproducibility of nanomechanical sensing in living cells publication-title: Commun. Biol. doi: 10.1038/s42003-018-0179-3 – volume: 164 year: 2020 ident: CR145 article-title: Paper-based ITP technology: an application to specific cancer-derived exosome detection and analysis publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112292 – volume: 7 start-page: 122 issue: 2 year: 2021 end-page: 133 ident: CR7 article-title: Extracellular vesicles in cancer detection: hopes and hypes publication-title: Trends in Cancer doi: 10.1016/j.trecan.2020.09.003 – volume: 4 start-page: 2065 issue: 8 year: 2019 end-page: 2072 ident: CR202 article-title: Multiplexed DNA identification using site specific dCas9 barcodes and nanopore sensing publication-title: ACS Sens. doi: 10.1021/acssensors.9b00686 – volume: 111 start-page: 1310 issue: 4 year: 2014 end-page: 1315 ident: CR139 article-title: Weighing nanoparticles in solution at the attogram scale publication-title: PNAS doi: 10.1073/pnas.1318602111 – volume: 92 start-page: 5404 issue: 7 year: 2020 end-page: 5410 ident: CR101 article-title: Magneto-mediated electrochemical sensor for simultaneous analysis of breast cancer exosomal proteins publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c00106 – volume: 111 start-page: 14888 issue: 41 year: 2014 end-page: 14893 ident: CR72 article-title: Quantitative and stoichiometric analysis of the microRNA content of exosomes publication-title: PNAS doi: 10.1073/pnas.1408301111 – volume: 5 start-page: 29975 issue: 1 year: 2016 ident: CR162 article-title: A novel multiplex bead-based platform highlights the diversity of extracellular vesicles publication-title: J. Extracell. Vesicles doi: 10.3402/jev.v5.29975 – volume: 12 start-page: 2878 issue: 547 year: 2020 ident: CR206 article-title: Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaz2878 – volume: 92 start-page: 13647 issue: 20 year: 2020 end-page: 13651 ident: CR133 article-title: Facile impedimetric analysis of neuronal exosome markers in Parkinson’s disease diagnostics publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c03092 – volume: 27 start-page: 255 issue: 1 year: 2019 end-page: 268.e6 ident: CR124 article-title: Methods for systematic identification of membrane proteins for specific capture of cancer-derived extracellular vesicles publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.03.003 – volume: 85 start-page: 11265 issue: 23 year: 2013 end-page: 11274 ident: CR81 article-title: Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons publication-title: Anal. Chem. doi: 10.1021/ac401983w – volume: 145 start-page: 2828 issue: 8 year: 2020 end-page: 2840 ident: CR208 article-title: Multiplexed detection of biomarkers in lateral-flow immunoassays publication-title: Analyst doi: 10.1039/C9AN02485A – volume: 2 start-page: 104 issue: 2 year: 2021 end-page: 126 ident: CR10 article-title: Identification of important extracellular vesicle RNA molecules related to sperm motility and prostate cancer publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.02 – volume: 58 start-page: 1612 issue: 6 year: 2019 end-page: 1615 ident: CR91 article-title: A pretreatment-free, polymer-based platform prepared by molecular imprinting and post-imprinting modifications for sensing intact exosomes publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201811142 – year: 2021 ident: CR15 article-title: Validation of α-synuclein in L1CAM-immunocaptured exosomes as a biomarker for the stratification of parkinsonian syndromes publication-title: Mov. Disord. doi: 10.1002/mds.28591 – volume: 6 start-page: 35928 issue: 1 year: 2016 ident: CR166 article-title: Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses publication-title: Sci. Rep. doi: 10.1038/srep35928 – ident: CR214 – volume: 4 start-page: 4684 issue: 6 year: 2021 end-page: 4705 ident: CR119 article-title: Surface plasmon-assisted fluorescence enhancing and quenching: from theory to application publication-title: ACS Appl. Bio Mater. doi: 10.1021/acsabm.1c00320 – volume: 11 start-page: 258 issue: 258 year: 2020 ident: CR78 article-title: Non-invasive detection of exosomal microRNAs via tethered cationic lipoplex nanoparticles (tCLN) biochip for lung cancer early detection publication-title: Front. Genet. doi: 10.3389/fgene.2020.00258 – volume: 16 start-page: 1907521 issue: 17 year: 2020 ident: CR187 article-title: Multiplexed luminescence oxygen channeling immunoassay based on dual-functional barcodes with a host-guest structure: a facile and robust suspension array platform publication-title: Small doi: 10.1002/smll.201907521 – year: 2021 ident: CR216 article-title: Microfluidics-based technologies for the analysis of extracellular vesicles at the single-cell level and single-vesicle level publication-title: Chin. Chem. Lett. doi: 10.1016/j.cclet.2021.09.058 – volume: 4 start-page: 1900309 issue: 12 year: 2020 ident: CR213 article-title: Biomarker organization in circulating extracellular vesicles: new applications in detecting neurodegenerative diseases publication-title: Adv. Biosyst. doi: 10.1002/adbi.201900309 – volume: 11 start-page: 79 issue: 1 year: 2019 ident: CR105 article-title: Extracellular vesicle (EV)-polyphenol nanoaggregates for microrna-based cancer diagnosis publication-title: NPG Asia Mater. doi: 10.1038/s41427-019-0184-0 – volume: 2 start-page: 1 issue: 1 year: 2021 end-page: 2 ident: CR2 article-title: Advances in EV isolation technology and function publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.09 – volume: 779 start-page: 229 year: 2016 end-page: 235 ident: CR112 article-title: An antifouling electrode based on electrode–organic layer–nanoparticle constructs: electrodeposited organic layers versus self-assembled monolayers publication-title: J. Electroanal. Chem. doi: 10.1016/j.jelechem.2016.01.031 – volume: 6 start-page: 203 issue: 4 year: 2011 end-page: 215 ident: CR138 article-title: Comparative advantages of mechanical biosensors publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2011.44 – volume: 5 start-page: 764 issue: 3 year: 2020 end-page: 771 ident: CR36 article-title: Enabling sensitive phenotypic profiling of cancer-derived small extracellular vesicles using surface-enhanced Raman spectroscopy nanotags publication-title: ACS Sens. doi: 10.1021/acssensors.9b02377 – volume: 7 start-page: 569 issue: 4 year: 2017 end-page: 576 ident: CR13 article-title: A critical assessment of exosomes in the pathogenesis and stratification of Parkinson’s disease publication-title: J. Parkinsons. Dis. doi: 10.3233/JPD-171176 – volume: 23 start-page: 1519 issue: 12 year: 2013 end-page: 1526 ident: CR176 article-title: DNA-directed self-assembly of core-satellite plasmonic nanostructures: a highly sensitive and reproducible near-IR SERS sensor publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201202073 – volume: 27 start-page: 6144 issue: 40 year: 2015 end-page: 6150 ident: CR171 article-title: Enhancing quantum dots for bioimaging using advanced surface chemistry and advanced optical microscopy: application to silicon quantum dots (SiQDs) publication-title: Adv. Mater. doi: 10.1002/adma.201503223 – volume: 6 start-page: 8797 issue: 1 year: 2015 ident: CR175 article-title: Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection publication-title: Nat. Commun. doi: 10.1038/ncomms9797 – volume: 17 start-page: 2006230 issue: 21 year: 2021 ident: CR192 article-title: Array-based biosensors for bacteria detection: from the perspective of recognition publication-title: Small doi: 10.1002/smll.202006230 – volume: 15 start-page: 1656 issue: 7 year: 2015 end-page: 1666 ident: CR215 article-title: On-chip surface acoustic wave lysis and ion-exchange nanomembrane detection of exosomal RNA for pancreatic cancer study and diagnosis publication-title: Lab Chip doi: 10.1039/C5LC00036J – volume: 3 start-page: 1553 issue: 8 year: 2018 end-page: 1561 ident: CR181 article-title: Graphene oxide signal reporter based multifunctional immunosensing platform for amperometric profiling of multiple cytokines in serum publication-title: ACS Sens. doi: 10.1021/acssensors.8b00365 – volume: 167 year: 2020 ident: CR147 article-title: Engineering strategies for enhancing the performance of electrochemical paper-based analytical devices publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112506 – volume: 10 start-page: 5321 issue: 1 year: 2019 ident: CR115 article-title: SERS discrimination of single DNA bases in single oligonucleotides by electro-plasmonic trapping publication-title: Nat. Commun. doi: 10.1038/s41467-019-13242-x – volume: 90 start-page: 6556 issue: 11 year: 2018 end-page: 6562 ident: CR158 article-title: Nanoparticle counting by microscopic digital detection: selective quantitative analysis of exosomes via surface-anchored nucleic acid amplification publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b00189 – volume: 17 start-page: 2007971 issue: 35 year: 2021 ident: CR5 article-title: Recent progress in detection and profiling of cancer cell-derived exosomes publication-title: Small doi: 10.1002/smll.202007971 – volume: 2 start-page: 150 issue: 1 year: 2020 end-page: 166 ident: CR106 article-title: Dual-selective magnetic analysis of extracellular vesicle glycans publication-title: Matter doi: 10.1016/j.matt.2019.10.018 – volume: 14 start-page: 5435 issue: 5 year: 2020 end-page: 5444 ident: CR220 article-title: Early-stage lung cancer diagnosis by deep learning-based spectroscopic analysis of circulating exosomes publication-title: ACS Nano doi: 10.1021/acsnano.9b09119 – volume: 16 start-page: 734 issue: 6 year: 2021 end-page: 742 ident: CR117 article-title: Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy publication-title: Nat. Nanotechnol. doi: 10.1038/s41565-021-00872-w – volume: 15 start-page: 1903761 issue: 47 year: 2019 ident: CR8 article-title: Functionalized DNA enables programming exosomes/vesicles for tumor imaging and therapy publication-title: Small doi: 10.1002/smll.201903761 – volume: 8 start-page: 6047 issue: 6 year: 2014 end-page: 6055 ident: CR143 article-title: Digital sensing and sizing of vesicular stomatitis virus pseudotypes in complex media: a model for Ebola and Marburg detection publication-title: ACS Nano doi: 10.1021/nn501312q – volume: 408 start-page: 284 issue: 2 year: 2011 end-page: 288 ident: CR152 article-title: Tetrabutylammonium phosphate-assisted separation of multiplex polymerase chain reaction products in non-gel sieving capillary electrophoresis publication-title: Anal. Biochem. doi: 10.1016/j.ab.2010.09.022 – volume: 771 start-page: 31 year: 2013 end-page: 36 ident: CR44 article-title: N-Methylimidazolium modified magnetic particles as adsorbents for solid phase extraction of genomic deoxyribonucleic acid from genetically modified soybeans publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2013.02.005 – volume: 184 start-page: 219 year: 2018 end-page: 226 ident: CR53 article-title: DAase I enzyme-aided fluorescence signal amplification based on graphene oxide-DNA aptamer interactions for colorectal cancer exosome detection publication-title: Talanta doi: 10.1016/j.talanta.2018.02.083 – volume: 20 start-page: 954 issue: 8 year: 2014 end-page: 960 ident: CR205 article-title: Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis publication-title: Nat. Med. doi: 10.1038/nm.3618 – volume: 17 start-page: 2008155 issue: 14 year: 2021 ident: CR52 article-title: Multiparametric profiling of single nanoscale extracellular vesicles by combined atomic force and fluorescence microscopy: correlation and heterogeneity in their molecular and biophysical features publication-title: Small doi: 10.1002/smll.202008155 – volume: 48 start-page: 850 issue: 3 year: 2019 end-page: 884 ident: CR189 article-title: Barcoded point-of-care bioassays publication-title: Chem. Soc. Rev. doi: 10.1039/C8CS00303C – volume: 3 start-page: 2560 issue: 5 year: 2020 end-page: 2567 ident: CR212 article-title: Simultaneous detection of exosomal membrane protein and RNA by highly sensitive aptamer assisted multiplex–PCR publication-title: ACS Appl. Bio Mater. doi: 10.1021/acsabm.9b00825 – volume: 8 start-page: 2102789 issue: 20 year: 2021 ident: CR222 article-title: Advanced nanotechnologies for extracellular vesicle-based liquid biopsy publication-title: Adv. Sci. doi: 10.1002/advs.202102789 – volume: 7 start-page: 6670 issue: 43 year: 2019 end-page: 6704 ident: CR186 article-title: Advanced liquid biopsy technologies for circulating biomarker detection publication-title: J. Mater. Chem. B doi: 10.1039/C9TB01490J – volume: 12 start-page: 3658 issue: 27 year: 2016 end-page: 3666 ident: CR90 article-title: A single-cell assay for time lapse studies of exosome secretion and cell behaviors publication-title: Small doi: 10.1002/smll.201600725 – ident: CR135 – volume: 3 start-page: 438 issue: 6 year: 2019 end-page: 451 ident: CR207 article-title: Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-019-0356-9 – volume: 360 start-page: 439 issue: 6387 year: 2018 end-page: 444 ident: CR199 article-title: Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6 publication-title: Science doi: 10.1126/science.aaq0179 – volume: 43 start-page: 2680 issue: 8 year: 2014 end-page: 2700 ident: CR170 article-title: Colloidal silicon quantum dots: from preparation to the modification of self-assembled monolayers (SAMs) for bio-applications publication-title: Chem. Soc. Rev. doi: 10.1039/C3CS60353A – volume: 2 start-page: 1800021 issue: 9 year: 2018 ident: CR24 article-title: Methods and technologies for exosome isolation and characterization publication-title: Small Methods doi: 10.1002/smtd.201800021 – volume: 35 start-page: 728 issue: 8 year: 2017 end-page: 742 ident: CR210 article-title: Multiplexed point-of-care testing–Xpoct publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2017.03.013 – volume: 46 start-page: S52 year: 2018 end-page: S63 ident: CR75 article-title: Detection of exosome miRNAs using molecular beacons for diagnosing prostate cancer publication-title: Artif. Cells Nanomed. Biotechnol. doi: 10.1080/21691401.2018.1489263 – volume: 7 start-page: 4168 issue: 17 year: 2017 end-page: 4182 ident: CR16 article-title: Extracellular vesicles in cardiovascular theranostics publication-title: Theranostics doi: 10.7150/thno.21274 – volume: 403 start-page: 27 issue: 1 year: 2012 end-page: 54 ident: CR41 article-title: Surface-enhanced Raman spectroscopy (SERS): progress and trends publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-011-5631-x – ident: CR204 – volume: 2 start-page: 55 issue: 1 year: 2021 end-page: 79 ident: CR14 article-title: Function of exosomes in neurological disorders and brain tumors publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.04 – volume: 16 start-page: 1903916 issue: 9 year: 2020 ident: CR46 article-title: Progress in microfluidics-based exosome separation and detection technologies for diagnostic applications publication-title: Small doi: 10.1002/smll.201903916 – volume: 5 start-page: 487 issue: 2 year: 2018 end-page: 494 ident: CR94 article-title: Analyses of intravesicular exosomal proteins using a nano-plasmonic system publication-title: ACS Photonics doi: 10.1021/acsphotonics.7b00992 – volume: 9 start-page: l3226 issue: 391 year: 2017 ident: CR102 article-title: Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aal3226 – volume: 181 year: 2021 ident: CR66 article-title: A pocket-sized device automates multiplexed point-of-care RNA testing for rapid screening of infectious pathogens publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2021.113145 – volume: 1 start-page: 1432 issue: 12 year: 2016 end-page: 1438 ident: CR132 article-title: Unique sensing interface that allows the development of an electrochemical immunosensor for the detection of tumor necrosis factor α in whole blood publication-title: ACS Sens. doi: 10.1021/acssensors.6b00532 – volume: 4 start-page: 2000003 issue: 12 year: 2020 ident: CR118 article-title: Plasmon-enhanced biosensing for multiplexed profiling of extracellular vesicles publication-title: Adv. Biosyst. doi: 10.1002/adbi.202000003 – volume: 128 start-page: 639 issue: 5 year: 2014 end-page: 650 ident: CR163 article-title: Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease publication-title: Acta Neuropathol. doi: 10.1007/s00401-014-1314-y – volume: 10 start-page: 1144 issue: 1 year: 2019 ident: CR68 article-title: Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition publication-title: Nat. Comm. doi: 10.1038/s41467-019-09030-2 – volume: 12 start-page: 7577 issue: 14 year: 2020 end-page: 7585 ident: CR110 article-title: Impact of metal crystallinity-related morphologies on the sensing performance of plasmonic nanohole arrays publication-title: Nanoscale doi: 10.1039/D0NR00619J – volume: 28 start-page: 2330 issue: 12 year: 2016 end-page: 2336 ident: CR32 article-title: Unclonable plasmonic security labels achieved by shadow-mask-lithography-assisted self-assembly publication-title: Adv. Mater. doi: 10.1002/adma.201505022 – volume: 92 start-page: 9877 issue: 14 year: 2020 end-page: 9886 ident: CR22 article-title: Multivalence-actuated DNA nanomachines enable bicolor exosomal phenotyping and PD-L1-guided therapy monitoring publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c01387 – volume: 34 start-page: 474 issue: 4 year: 2015 end-page: 490 ident: CR28 article-title: Proteomics of extracellular vesicles: exosomes and ectosomes publication-title: Mass Spectrom. Rev. doi: 10.1002/mas.21420 – volume: 123 year: 2020 ident: CR184 article-title: Recent advances in electrochemiluminescence-based simultaneous detection of multiple targets publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2019.115767 – volume: 554 start-page: 249 issue: 7691 year: 2018 end-page: 254 ident: CR21 article-title: High performance plasma amyloid-Β biomarkers for Alzheimer’s disease publication-title: Nature doi: 10.1038/nature25456 – volume: 18 start-page: 2917 issue: 19 year: 2018 end-page: 2925 ident: CR103 article-title: Detecting mirna biomarkers from extracellular vesicles for cardiovascular disease with a microfluidic system publication-title: Lab Chip doi: 10.1039/C8LC00386F – volume: 3 start-page: 2637 issue: 12 year: 2018 end-page: 2643 ident: CR35 article-title: Correlation between cancerous exosomes and protein markers based on surface-enhanced Raman spectroscopy (SERS) and principal component analysis (PCA) publication-title: ACS Sens. doi: 10.1021/acssensors.8b01047 – volume: 11 start-page: 145 issue: 3 year: 2014 end-page: 156 ident: CR71 article-title: Clinical relevance of circulating cell-free microRNAs in cancer publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2014.5 – volume: 181 year: 2021 ident: CR160 article-title: Multiplexed digital polymerase chain reaction as a powerful diagnostic tool publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2021.113155 – volume: 1 start-page: 2004 issue: 5 year: 2018 end-page: 2020 ident: CR25 article-title: Isolation and detection of tumor-derived extracellular vesicles publication-title: ACS Appl. Nano Mater. doi: 10.1021/acsanm.8b00267 – volume: 175 year: 2021 ident: CR114 article-title: Surface plasmon resonance imaging-based biosensor for multiplex and ultrasensitive detection of NSCLC-associated exosomal miRNAs using DNA programmed heterostructure of Au-on-Ag publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112835 – volume: 10 start-page: 5495 issue: 21 year: 2019 end-page: 5504 ident: CR99 article-title: Multiplexed immunophenotyping of circulating exosomes on nano-engineered exoprofile chip towards early diagnosis of cancer publication-title: Chem. Sci. doi: 10.1039/C9SC00961B – volume: 2 start-page: 202 issue: 3 year: 2021 end-page: 221 ident: CR4 article-title: Comparison of miRNA cargo in human adipose-tissue Vs amniotic-membrane derived mesenchymal stromal cells extracellular vesicles for osteoarthritis treatment publication-title: Extracell. Vesicles Circ. Nucleic Acids – volume: 14 start-page: 3773 issue: 19 year: 2014 end-page: 3780 ident: CR49 article-title: Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology publication-title: Lab Chip doi: 10.1039/C4LC00662C – volume: 58 start-page: 4983 issue: 15 year: 2019 end-page: 4987 ident: CR89 article-title: Near-infrared afterglow semiconducting nano-polycomplexes for the multiplex differentiation of cancer exosomes publication-title: Angew. Chem. Int. Ed. doi: 10.1002/ange.201900092 – volume: 15 start-page: 5631 issue: 3 year: 2021 end-page: 5638 ident: CR159 article-title: Sequencing-based protein analysis of single extracellular vesicles publication-title: ACS Nano doi: 10.1021/acsnano.1c00782 – volume: 37 start-page: 310 issue: 3 year: 2019 end-page: 324 ident: CR221 article-title: Deep learning with microfluidics for biotechnology publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2018.08.005 – volume: 7 issue: 6 year: 2020 ident: CR165 article-title: Immune profiling of plasma-derived extracellular vesicles identifies parkinson disease publication-title: Neurol. Neuroimmunol. doi: 10.1212/nxi.0000000000000866 – volume: 2 start-page: 80 issue: 1 year: 2021 end-page: 103 ident: CR26 article-title: Isolation and analysis methods of extracellular vesicles (EVs) publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.07 – volume: 21 start-page: 4643 issue: 11 year: 2021 end-page: 4653 ident: CR200 article-title: Droplet Cas12a assay enables DNA quantification from unamplified samples at the single-molecule level publication-title: Nano Lett. doi: 10.1021/acs.nanolett.1c00715 – volume: 13 start-page: 40 issue: 1 year: 2002 end-page: 46 ident: CR169 article-title: Luminescent quantum dots for multiplexed biological detection and imaging publication-title: Curr. Opin. Biotechnol. doi: 10.1016/S0958-1669(02)00282-3 – volume: 32 start-page: 2509 issue: 10 year: 2016 end-page: 2517 ident: CR150 article-title: Strategies to achieve control over the surface ratio of two different components on modified electrodes using aryldiazonium salts publication-title: Langmuir doi: 10.1021/acs.langmuir.5b04550 – volume: 59 start-page: 11423 issue: 28 year: 2020 end-page: 11431 ident: CR116 article-title: Multiplexed discrimination of single amino acid residues in polypeptides in a single SERS hot spot publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202000489 – volume: 86 start-page: 8857 issue: 17 year: 2014 end-page: 8864 ident: CR96 article-title: Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging publication-title: Anal. Chem. doi: 10.1021/ac5023056 – volume: 4 start-page: 26048 issue: 1 year: 2015 ident: CR125 article-title: Potentials and capabilities of the extracellular vesicle (EV) array publication-title: J. Extracell. Vesicles doi: 10.3402/jev.v4.26048 – volume: 53 start-page: 13145 issue: 48 year: 2014 end-page: 13149 ident: CR180 article-title: Highly specific electrochemical analysis of cancer cells using multi-nanoparticle labeling publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201407982 – volume: 13 start-page: 58 year: 2021 ident: CR194 article-title: Gold nanostars-AIE theranostic nanodots with enhanced fluorescence and photosensitization towards effective image-guided photodynamic therapy publication-title: Nano-Micro Lett. doi: 10.1007/s40820-020-00583-2 – volume: 136 year: 2021 ident: CR146 article-title: Enhancing the analytical performance of paper lateral flow assays: from chemistry to engineering publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2021.116200 – volume: 117 start-page: 678 year: 2018 end-page: 689 ident: CR122 article-title: Signal amplification strategies for DNA-based surface plasmon resonance biosensors publication-title: Biosensors Bioelectron. doi: 10.1016/j.bios.2018.06.062 – volume: 144 start-page: 5856 issue: 19 year: 2019 end-page: 5865 ident: CR3 article-title: Exosome-specific tumor diagnosis via biomedical analysis of exosome-containing microrna biomarkers publication-title: Analyst doi: 10.1039/C9AN00777F – volume: 8 start-page: 2722 issue: 10 year: 2018 ident: CR95 article-title: Molecular detection and analysis of exosomes using surface-enhanced Raman scattering gold nanorods and a miniaturized device publication-title: Theranostics doi: 10.7150/thno.21358 – volume: 102 start-page: 204 year: 2018 end-page: 210 ident: CR87 article-title: Target-induced proximity ligation triggers recombinase polymerase amplification and transcription-mediated amplification to detect tumor-derived exosomes in nasopharyngeal carcinoma with high sensitivity publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2017.11.033 – volume: 94 start-page: 400 year: 2017 end-page: 407 ident: CR108 article-title: Direct detection of two different tumor-derived extracellular vesicles by SAM-AuNIs LSPR biosensor publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2017.03.036 – volume: 77 start-page: 518 year: 2016 end-page: 524 ident: CR173 article-title: Merging colloidal nanoplasmonics and surface plasmon resonance spectroscopy for enhanced profiling of multiple myeloma-derived exosomes publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2015.09.061 – volume: 10 start-page: 43375 issue: 50 year: 2018 end-page: 43386 ident: CR79 article-title: An immuno-biochip selectively captures tumor-derived exosomes and detects exosomal RNAs for cancer diagnosis publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.8b13971 – volume: 3 start-page: 183 issue: 3 year: 2019 end-page: 193 ident: CR57 article-title: Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-018-0343-6 – volume: 86 start-page: 11125 issue: 22 year: 2014 end-page: 11132 ident: CR84 article-title: Detecting exosomes specifically: a multiplexed device based on alternating current electrohydrodynamic induced nanoshearing publication-title: Anal. Chem. doi: 10.1021/ac502082b – volume: 12 start-page: 70 year: 2020 ident: CR29 article-title: Recent advances of persistent luminescence nanoparticles in bioapplications publication-title: Nano-Micro Lett. doi: 10.1007/s40820-020-0404-8 – volume: 143 start-page: 1290 issue: 3 year: 2021 end-page: 1295 ident: CR69 article-title: Molecular identification of tumor-derived extracellular vesicles using thermophoresis-mediated DNA computation publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.0c12016 – volume: 2 start-page: 20210003 issue: 4 year: 2021 ident: CR73 article-title: Point-of-care detection of cytokines in cytokine storm management and beyond: significance and challenges publication-title: VIEW doi: 10.1002/VIW.20210003 – volume: 41 start-page: 3297 issue: 8 year: 2012 end-page: 3317 ident: CR178 article-title: Bio-inspired variable structural color materials publication-title: Chem. Soc. Rev. doi: 10.1039/C2CS15267C – volume: 145 start-page: 3289 year: 2020 end-page: 3296 ident: CR104 article-title: In situ multiplex detection of serum exosomal micrornas using all-in-one biosensor for breast cancer diagnosis publication-title: Analyst doi: 10.1039/D0AN00393J – volume: 8 start-page: 2000162 issue: 14 year: 2020 ident: CR193 article-title: AIE bioconjugates for biomedical applications publication-title: Adv. Opt. Mater. doi: 10.1002/adom.202000162 – volume: 11 start-page: 11041 issue: 11 year: 2017 end-page: 11046 ident: CR129 article-title: Integrated kidney exosome analysis for the detection of kidney transplant rejection publication-title: ACS Nano doi: 10.1021/acsnano.7b05083 – volume: 58 start-page: 5190 issue: 16 year: 2019 end-page: 5200 ident: CR190 article-title: Array-based “chemical nose” sensing in diagnostics and drug discovery publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201809607 – volume: 12 start-page: 671 issue: 1 year: 2018 end-page: 680 ident: CR168 article-title: Protein profiling and sizing of extracellular vesicles from colorectal cancer patients via flow cytometry publication-title: ACS Nano doi: 10.1021/acsnano.7b07782 – volume: 123 year: 2020 ident: CR19 article-title: Advances in biosensing technologies for analysis of cancer-derived exosomes publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2019.115773 – volume: 14 start-page: 14528 issue: 11 year: 2020 end-page: 14548 ident: CR120 article-title: Plasmonic sensors for extracellular vesicle analysis: from scientific development to translational research publication-title: ACS Nano doi: 10.1021/acsnano.0c07581 – volume: 128 start-page: 10395 issue: 35 year: 2016 end-page: 10399 ident: CR167 article-title: Label-free analysis of single viruses with a resolution comparable to that of electron microscopy and the throughput of flow cytometry publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201603007 – volume: 12 start-page: 1407 issue: 5 year: 2016 end-page: 1419 ident: CR27 article-title: Proteomic analysis of exosomal cargo: the challenge of high purity vesicle isolation publication-title: Mol. Biosyst. doi: 10.1039/C6MB00082G – volume: 10 issue: 1 year: 2020 ident: CR62 article-title: Localized fluorescent imaging of multiple proteins on individual extracellular vesicles using rolling circle amplification for cancer diagnosis publication-title: J. Extracell. Vesicles doi: 10.1002/jev2.12025 – volume: 46 start-page: 3945 issue: 13 year: 2017 end-page: 3961 ident: CR42 article-title: Recent progress in surface-enhanced Raman spectroscopy for biological and biomedical applications: from cells to clinics publication-title: Chem. Soc. Rev. doi: 10.1039/C7CS00172J – volume: 92 start-page: 1574 issue: 1 year: 2020 end-page: 1581 ident: CR100 article-title: Integrated microfluidic device for accurate extracellular vesicle quantification and protein markers analysis directly from human whole blood publication-title: Anal. Chem. doi: 10.1021/acs.analchem.9b04852 – volume: 6 start-page: eaax3223 issue: 9 year: 2020 ident: CR39 article-title: Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma publication-title: Sci. Adv. doi: 10.1126/sciadv.aax3223 – volume: 6 start-page: eabc1204 issue: 47 year: 2020 ident: CR80 article-title: High-throughput single-EV liquid biopsy: rapid, simultaneous, and multiplexed detection of nucleic acids, proteins, and their combinations publication-title: Sci. Adv. doi: 10.1126/sciadv.abc1204 – volume: 8 start-page: 15137 issue: 33 year: 2016 end-page: 15141 ident: CR140 article-title: Nanomechanical sandwich assay for multiple cancer biomarkers in breast cancer cell-derived exosomes publication-title: Nanoscale doi: 10.1039/C6NR03478K – volume: 6 start-page: 37246 year: 2016 ident: CR141 article-title: Digital detection of exosomes by interferometric imaging publication-title: Sci. Rep. doi: 10.1038/srep37246 – volume: 32 start-page: 490 issue: 5 year: 2014 end-page: 495 ident: CR86 article-title: Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2886 – volume: 7 start-page: 821 issue: 12 year: 2012 end-page: 824 ident: CR174 article-title: Plasmonic elisa for the ultrasensitive detection of disease biomarkers with the naked eye publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2012.186 – volume: 139 year: 2021 ident: CR154 article-title: Recent advances in the detection of multiple micrornas publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2021.116269 – volume: 12 start-page: 727 issue: 6 year: 2016 end-page: 732 ident: CR179 article-title: Interrogating circulating microsomes and exosomes using metal nanoparticles publication-title: Small doi: 10.1002/smll.201502365 – volume: 91 start-page: 720 year: 2020 end-page: 729 ident: CR93 article-title: Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp-2019-322588 – volume: 9 start-page: 1326 issue: 1326 year: 2018 ident: CR164 article-title: Systematic methodological evaluation of a multiplex bead-based flow cytometry assay for detection of extracellular vesicle surface signatures publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.01326 – volume: 10 start-page: 9053 year: 2018 end-page: 9062 ident: CR37 article-title: Screening and multiple detection of cancerous exosomes using a SERS-based method publication-title: Nanoscale doi: 10.1039/C7NR09162A – volume: 120 start-page: 1649 issue: 10 year: 2017 end-page: 1657 ident: CR17 article-title: Extracellular vesicles in cardiovascular disease publication-title: Circul. Res. doi: 10.1161/CIRCRESAHA.117.310752 – volume: 3 start-page: e1501645 issue: 3 year: 2017 ident: CR64 article-title: Self-powered integrated microfluidic point-of-care low-cost enabling (SIMPLE) chip publication-title: Sci. Adv. doi: 10.1126/sciadv.1501645 – volume: 92 start-page: 8 year: 2017 end-page: 15 ident: CR55 article-title: A visible and colorimetric aptasensor based on DNA-capped single-walled carbon nanotubes for detection of exosomes publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2017.01.063 – volume: 2 start-page: 318 issue: 5 year: 2007 end-page: 323 ident: CR191 article-title: Detection and identification of proteins using nanoparticle–fluorescent polymer ‘chemical nose’ sensors publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2007.99 – volume: 582 start-page: 277 issue: 7811 year: 2020 end-page: 282 ident: CR201 article-title: Massively multiplexed nucleic acid detection with Cas13 publication-title: Nature doi: 10.1038/s41586-020-2279-8 – volume: 13 start-page: 92 year: 2021 ident: CR23 article-title: Recent advancements in nanomedicine for ‘cold’ tumor immunotherapy publication-title: Nano-Micro Lett. doi: 10.1007/s40820-021-00622-6 – volume: 5 start-page: 12539 issue: 1 year: 2015 ident: CR151 article-title: Quantitative determination of target gene with electrical sensor publication-title: Sci. Rep. doi: 10.1038/srep12539 – volume: 86 start-page: 202 year: 2016 end-page: 210 ident: CR74 article-title: Simultaneous and multiplexed detection of exosome micrornas using molecular beacons publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2016.06.058 – volume: 9 start-page: 5031 issue: 6 year: 2017 end-page: 5049 ident: CR218 article-title: Advances on aryldiazonium salt chemistry based interfacial fabrication for sensing applications publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.6b16108 – volume: 154 year: 2020 ident: CR50 article-title: Recent advances in single extracellular vesicle detection methods publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112056 – volume: 10 start-page: 1802 issue: 2 year: 2016 end-page: 1809 ident: CR92 article-title: Integrated magneto–electrochemical sensor for exosome analysis publication-title: ACS Nano doi: 10.1021/acsnano.5b07584 – volume: 37 start-page: 792 issue: 8 year: 2019 end-page: 795 ident: CR196 article-title: CRISPR/Cas multiplexed biosensing: a challenge or an insurmountable obstacle? publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2019.04.012 – ident: CR197 – volume: 141 start-page: 3817 issue: 9 year: 2019 end-page: 3821 ident: CR85 article-title: λ-DNA- and aptamer-mediated sorting and analysis of extracellular vesicles publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b00007 – volume: 13 start-page: 96 year: 2021 ident: CR34 article-title: Targeted sub-attomole cancer biomarker detection based on phase singularity 2D nanomaterial-enhanced plasmonic biosensor publication-title: Nano-Micro Lett. doi: 10.1007/s40820-021-00613-7 – volume: 4 start-page: 1900307 issue: 12 year: 2020 ident: CR157 article-title: Single extracellular vesicle protein analysis using immuno-droplet digital polymerase chain reaction amplification publication-title: Adv. Biosyst. doi: 10.1002/adbi.201900307 – volume: 12 issue: 4 year: 2017 ident: CR48 article-title: Clinical application of a microfluidic chip for immunocapture and quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification publication-title: PLoS ONE doi: 10.1371/journal.pone.0175050 – volume: 87 start-page: 38 year: 2017 end-page: 45 ident: CR142 article-title: Point-of-care detection of extracellular vesicles: sensitivity optimization and multiple-target detection publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2016.08.001 – volume: 29 start-page: 700 issue: 3 year: 2018 end-page: 706 ident: CR219 article-title: Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma publication-title: Ann. Oncol. doi: 10.1093/annonc/mdx765 – year: 2021 ident: CR58 article-title: Thermomicrofluidics for biosensing applications publication-title: VIEW doi: 10.1002/VIW.20200148 – volume: 60 start-page: 7582 issue: 14 year: 2021 end-page: 7586 ident: CR59 article-title: Tracing tumor-derived exosomal PD-L1 by dual-aptamer activated proximity-induced droplet digital PCR publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202015628 – volume: 20 start-page: 2423 issue: 14 year: 2020 end-page: 2437 ident: CR40 article-title: Emerging technologies for profiling extracellular vesicle heterogeneity publication-title: Lab Chip doi: 10.1039/D0LC00431F – volume: 59 start-page: 20754 issue: 47 year: 2020 end-page: 20766 ident: CR198 article-title: CRISPR mediated biosensing toward understanding cellular biology and point-of-care diagnosis publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202005398 – volume: 4 start-page: 2000003 issue: 12 year: 2020 ident: 753_CR118 publication-title: Adv. Biosyst. doi: 10.1002/adbi.202000003 – volume: 7 start-page: 4168 issue: 17 year: 2017 ident: 753_CR16 publication-title: Theranostics doi: 10.7150/thno.21274 – volume: 46 start-page: S52 year: 2018 ident: 753_CR75 publication-title: Artif. Cells Nanomed. Biotechnol. doi: 10.1080/21691401.2018.1489263 – ident: 753_CR197 doi: 10.1101/2020.06.17.157180 – volume: 13 start-page: 40 issue: 1 year: 2002 ident: 753_CR169 publication-title: Curr. Opin. Biotechnol. doi: 10.1016/S0958-1669(02)00282-3 – volume: 2 start-page: 353 issue: 4 year: 2015 ident: 753_CR11 publication-title: Ann. Clin. Transl. Neurol. doi: 10.1002/acn3.175 – volume: 123 start-page: 85 issue: 1 year: 2019 ident: 753_CR211 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2018.06.018 – volume: 11 start-page: 145 issue: 3 year: 2014 ident: 753_CR71 publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2014.5 – volume: 9 start-page: 1326 issue: 1326 year: 2018 ident: 753_CR164 publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.01326 – volume: 17 start-page: 2006230 issue: 21 year: 2021 ident: 753_CR192 publication-title: Small doi: 10.1002/smll.202006230 – volume: 60 start-page: 7582 issue: 14 year: 2021 ident: 753_CR59 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202015628 – volume: 120 start-page: 3852 issue: 8 year: 2020 ident: 753_CR113 publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.9b00739 – ident: 753_CR135 – volume: 2 start-page: 148 issue: 2 year: 2021 ident: 753_CR9 publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.06 – volume: 13 start-page: 92 year: 2021 ident: 753_CR23 publication-title: Nano-Micro Lett. doi: 10.1007/s40820-021-00622-6 – volume: 198 start-page: 87 year: 2019 ident: 753_CR161 publication-title: J. Proteomics doi: 10.1016/j.jprot.2018.12.023 – volume: 128 start-page: 639 issue: 5 year: 2014 ident: 753_CR163 publication-title: Acta Neuropathol. doi: 10.1007/s00401-014-1314-y – volume: 7 issue: 6 year: 2020 ident: 753_CR165 publication-title: Neurol. Neuroimmunol. doi: 10.1212/nxi.0000000000000866 – volume: 32 start-page: 490 issue: 5 year: 2014 ident: 753_CR86 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2886 – volume: 10 start-page: 5321 issue: 1 year: 2019 ident: 753_CR115 publication-title: Nat. Commun. doi: 10.1038/s41467-019-13242-x – volume: 144 start-page: 5856 issue: 19 year: 2019 ident: 753_CR3 publication-title: Analyst doi: 10.1039/C9AN00777F – volume: 86 start-page: 5929 issue: 12 year: 2014 ident: 753_CR107 publication-title: Anal. Chem. doi: 10.1021/ac500931f – volume: 15 start-page: 1167 issue: 1 year: 2021 ident: 753_CR67 publication-title: ACS Nano doi: 10.1021/acsnano.0c08165 – volume: 59 start-page: 11423 issue: 28 year: 2020 ident: 753_CR116 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202000489 – volume: 1175 year: 2021 ident: 753_CR20 publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2021.338633 – volume: 408 start-page: 284 issue: 2 year: 2011 ident: 753_CR152 publication-title: Anal. Biochem. doi: 10.1016/j.ab.2010.09.022 – volume: 1 start-page: 0021 issue: 4 year: 2017 ident: 753_CR177 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-016-0021 – volume: 77 start-page: 518 year: 2016 ident: 753_CR173 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2015.09.061 – volume: 7 start-page: 821 issue: 12 year: 2012 ident: 753_CR174 publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2012.186 – volume: 59 start-page: 20754 issue: 47 year: 2020 ident: 753_CR198 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.202005398 – volume: 13 start-page: 18 year: 2020 ident: 753_CR217 publication-title: Nano-Micro Lett. doi: 10.1007/s40820-020-00533-y – volume: 120 start-page: 1649 issue: 10 year: 2017 ident: 753_CR17 publication-title: Circul. Res. doi: 10.1161/CIRCRESAHA.117.310752 – volume: 16 start-page: 1903916 issue: 9 year: 2020 ident: 753_CR46 publication-title: Small doi: 10.1002/smll.201903916 – volume: 179 start-page: 257 issue: 3 year: 2012 ident: 753_CR47 publication-title: Microchim. Acta doi: 10.1007/s00604-012-0894-2 – volume: 17 start-page: 2007971 issue: 35 year: 2021 ident: 753_CR5 publication-title: Small doi: 10.1002/smll.202007971 – volume: 85 start-page: 11265 issue: 23 year: 2013 ident: 753_CR81 publication-title: Anal. Chem. doi: 10.1021/ac401983w – volume: 164 year: 2020 ident: 753_CR145 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112292 – volume: 7 start-page: 122 issue: 2 year: 2021 ident: 753_CR7 publication-title: Trends in Cancer doi: 10.1016/j.trecan.2020.09.003 – volume: 141 start-page: 3817 issue: 9 year: 2019 ident: 753_CR85 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b00007 – volume: 116 start-page: 46 year: 2018 ident: 753_CR6 publication-title: Lung Cancer doi: 10.1016/j.lungcan.2017.12.012 – volume: 53 start-page: 13145 issue: 48 year: 2014 ident: 753_CR180 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201407982 – volume: 118 start-page: 1917 issue: 4 year: 2018 ident: 753_CR18 publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.7b00534 – volume: 123 start-page: 5164 issue: 21 year: 2001 ident: 753_CR172 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja0102639 – volume: 27 start-page: 884 issue: 4 year: 2015 ident: 753_CR136 publication-title: Electroanalysis doi: 10.1002/elan.201400557 – volume: 5 start-page: 764 issue: 3 year: 2020 ident: 753_CR36 publication-title: ACS Sens. doi: 10.1021/acssensors.9b02377 – volume: 6 start-page: 35928 issue: 1 year: 2016 ident: 753_CR166 publication-title: Sci. Rep. doi: 10.1038/srep35928 – volume: 6 start-page: eabc1204 issue: 47 year: 2020 ident: 753_CR80 publication-title: Sci. Adv. doi: 10.1126/sciadv.abc1204 – volume: 2 start-page: 150 issue: 1 year: 2020 ident: 753_CR106 publication-title: Matter doi: 10.1016/j.matt.2019.10.018 – volume: 12 start-page: 2878 issue: 547 year: 2020 ident: 753_CR206 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaz2878 – volume: 142 start-page: 4996 issue: 11 year: 2020 ident: 753_CR70 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b13960 – volume: 117 start-page: 128 year: 2019 ident: 753_CR128 publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2019.05.013 – volume: 145 start-page: 2828 issue: 8 year: 2020 ident: 753_CR208 publication-title: Analyst doi: 10.1039/C9AN02485A – volume: 89 start-page: 3184 issue: 5 year: 2017 ident: 753_CR12 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.6b05037 – volume: 11 start-page: 79 issue: 1 year: 2019 ident: 753_CR105 publication-title: NPG Asia Mater. doi: 10.1038/s41427-019-0184-0 – volume: 83 start-page: 337 issue: 2 year: 2010 ident: 753_CR45 publication-title: Talanta doi: 10.1016/j.talanta.2010.09.023 – volume: 6 start-page: 37246 year: 2016 ident: 753_CR141 publication-title: Sci. Rep. doi: 10.1038/srep37246 – volume: 27 start-page: 6144 issue: 40 year: 2015 ident: 753_CR171 publication-title: Adv. Mater. doi: 10.1002/adma.201503223 – volume: 779 start-page: 229 year: 2016 ident: 753_CR112 publication-title: J. Electroanal. Chem. doi: 10.1016/j.jelechem.2016.01.031 – volume: 92 start-page: 13647 issue: 20 year: 2020 ident: 753_CR133 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c03092 – volume: 6 start-page: 203 issue: 4 year: 2011 ident: 753_CR138 publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2011.44 – volume: 8 start-page: 6047 issue: 6 year: 2014 ident: 753_CR143 publication-title: ACS Nano doi: 10.1021/nn501312q – volume: 4 start-page: 2065 issue: 8 year: 2019 ident: 753_CR202 publication-title: ACS Sens. doi: 10.1021/acssensors.9b00686 – volume: 6 start-page: 34358 year: 2016 ident: 753_CR61 publication-title: Sci. Rep. doi: 10.1038/srep34358 – volume: 8 start-page: 15137 issue: 33 year: 2016 ident: 753_CR140 publication-title: Nanoscale doi: 10.1039/C6NR03478K – volume: 1 start-page: 2004 issue: 5 year: 2018 ident: 753_CR25 publication-title: ACS Appl. Nano Mater. doi: 10.1021/acsanm.8b00267 – volume: 143 start-page: 1290 issue: 3 year: 2021 ident: 753_CR69 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.0c12016 – volume: 136 year: 2021 ident: 753_CR146 publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2021.116200 – volume: 10 issue: 1 year: 2020 ident: 753_CR62 publication-title: J. Extracell. Vesicles doi: 10.1002/jev2.12025 – volume: 15 start-page: 1903761 issue: 47 year: 2019 ident: 753_CR8 publication-title: Small doi: 10.1002/smll.201903761 – volume: 3 start-page: 183 issue: 3 year: 2019 ident: 753_CR57 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-018-0343-6 – volume: 118 start-page: 4946 issue: 10 year: 2018 ident: 753_CR30 publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.7b00668 – volume: 19 start-page: 7623 issue: 11 year: 2019 ident: 753_CR97 publication-title: Nano Lett. doi: 10.1021/acs.nanolett.9b02232 – volume: 785 start-page: 265 year: 2017 ident: 753_CR134 publication-title: J. Electroanal. Chem. doi: 10.1016/j.jelechem.2016.11.043 – volume: 18 start-page: 2917 issue: 19 year: 2018 ident: 753_CR103 publication-title: Lab Chip doi: 10.1039/C8LC00386F – volume: 13 start-page: 96 year: 2021 ident: 753_CR34 publication-title: Nano-Micro Lett. doi: 10.1007/s40820-021-00613-7 – volume: 92 start-page: 8 year: 2017 ident: 753_CR55 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2017.01.063 – volume: 8 start-page: 2722 issue: 10 year: 2018 ident: 753_CR95 publication-title: Theranostics doi: 10.7150/thno.21358 – volume: 23 start-page: 1519 issue: 12 year: 2013 ident: 753_CR176 publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201202073 – volume: 35 start-page: 728 issue: 8 year: 2017 ident: 753_CR210 publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2017.03.013 – volume: 12 issue: 4 year: 2017 ident: 753_CR48 publication-title: PLoS ONE doi: 10.1371/journal.pone.0175050 – volume: 11 start-page: 258 issue: 258 year: 2020 ident: 753_CR78 publication-title: Front. Genet. doi: 10.3389/fgene.2020.00258 – volume: 90 start-page: 13451 issue: 22 year: 2018 ident: 753_CR127 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b03272 – volume: 86 start-page: 8857 issue: 17 year: 2014 ident: 753_CR96 publication-title: Anal. Chem. doi: 10.1021/ac5023056 – year: 2021 ident: 753_CR58 publication-title: VIEW doi: 10.1002/VIW.20200148 – volume: 12 start-page: 3658 issue: 27 year: 2016 ident: 753_CR90 publication-title: Small doi: 10.1002/smll.201600725 – volume: 91 start-page: 720 year: 2020 ident: 753_CR93 publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp-2019-322588 – volume: 21 start-page: 606 issue: 5 year: 2019 ident: 753_CR223 publication-title: Neuro Oncol. doi: 10.1093/neuonc/noy187 – volume: 4 start-page: 1900309 issue: 12 year: 2020 ident: 753_CR213 publication-title: Adv. Biosyst. doi: 10.1002/adbi.201900309 – volume: 28 start-page: 2330 issue: 12 year: 2016 ident: 753_CR32 publication-title: Adv. Mater. doi: 10.1002/adma.201505022 – volume: 403 start-page: 27 issue: 1 year: 2012 ident: 753_CR41 publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-011-5631-x – volume: 142 start-page: 6617 issue: 14 year: 2020 ident: 753_CR98 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b13874 – volume: 2 start-page: 20920 issue: 1 year: 2013 ident: 753_CR123 publication-title: J. Extracell. Vesicles doi: 10.3402/jev.v2i0.20920 – volume: 360 start-page: 439 issue: 6387 year: 2018 ident: 753_CR199 publication-title: Science doi: 10.1126/science.aaq0179 – year: 2021 ident: 753_CR15 publication-title: Mov. Disord. doi: 10.1002/mds.28591 – volume: 10 start-page: 5495 issue: 21 year: 2019 ident: 753_CR99 publication-title: Chem. Sci. doi: 10.1039/C9SC00961B – ident: 753_CR214 doi: 10.1007/978-1-4939-6866-4_5 – volume: 1 start-page: 1036 issue: 8 year: 2016 ident: 753_CR130 publication-title: ACS Sens. doi: 10.1021/acssensors.6b00256 – volume: 145 start-page: 2873 issue: 8 year: 2020 ident: 753_CR209 publication-title: Analyst doi: 10.1039/C9AN02294E – volume: 9 start-page: 5031 issue: 6 year: 2017 ident: 753_CR218 publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.6b16108 – volume: 3 start-page: 2637 issue: 12 year: 2018 ident: 753_CR35 publication-title: ACS Sens. doi: 10.1021/acssensors.8b01047 – volume: 116 start-page: 4489 issue: 10 year: 2019 ident: 753_CR65 publication-title: PNAS doi: 10.1073/pnas.1814110116 – volume: 175 year: 2021 ident: 753_CR114 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112835 – volume: 92 start-page: 10569 issue: 15 year: 2020 ident: 753_CR155 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c01464 – volume: 2 start-page: 55 issue: 1 year: 2021 ident: 753_CR14 publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.04 – volume: 167 year: 2020 ident: 753_CR147 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112506 – volume: 10 start-page: 319 issue: 2 year: 2021 ident: 753_CR76 publication-title: J. Clin. Med. doi: 10.3390/jcm10020319 – volume: 92 start-page: 5404 issue: 7 year: 2020 ident: 753_CR101 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c00106 – volume: 13 issue: 6 year: 2018 ident: 753_CR82 publication-title: PLoS ONE doi: 10.1371/journal.pone.0198552 – volume: 5 start-page: 12539 issue: 1 year: 2015 ident: 753_CR151 publication-title: Sci. Rep. doi: 10.1038/srep12539 – volume: 4 start-page: 4684 issue: 6 year: 2021 ident: 753_CR119 publication-title: ACS Appl. Bio Mater. doi: 10.1021/acsabm.1c00320 – volume: 87 start-page: 38 year: 2017 ident: 753_CR142 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2016.08.001 – volume: 10 start-page: 43375 issue: 50 year: 2018 ident: 753_CR79 publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.8b13971 – ident: 753_CR204 doi: 10.1109/SENSORS43011.2019.8956561 – volume: 145 start-page: 3289 year: 2020 ident: 753_CR104 publication-title: Analyst doi: 10.1039/D0AN00393J – volume: 3 start-page: 438 issue: 6 year: 2019 ident: 753_CR207 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-019-0356-9 – volume: 37 start-page: 792 issue: 8 year: 2019 ident: 753_CR196 publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2019.04.012 – volume: 102 start-page: 204 year: 2018 ident: 753_CR87 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2017.11.033 – volume: 10 start-page: 3854 issue: 1 year: 2019 ident: 753_CR60 publication-title: Nat. Comm. doi: 10.1038/s41467-019-11486-1 – volume: 16 start-page: 734 issue: 6 year: 2021 ident: 753_CR117 publication-title: Nat. Nanotechnol. doi: 10.1038/s41565-021-00872-w – volume: 16 start-page: 1907521 issue: 17 year: 2020 ident: 753_CR187 publication-title: Small doi: 10.1002/smll.201907521 – volume: 2 start-page: 202 issue: 3 year: 2021 ident: 753_CR4 publication-title: Extracell. Vesicles Circ. Nucleic Acids – volume: 142 year: 2019 ident: 753_CR121 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2019.111565 – volume: 92 start-page: 1574 issue: 1 year: 2020 ident: 753_CR100 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.9b04852 – volume: 181 year: 2021 ident: 753_CR66 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2021.113145 – volume: 58 start-page: 5190 issue: 16 year: 2019 ident: 753_CR190 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201809607 – volume: 139 year: 2021 ident: 753_CR154 publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2021.116269 – volume: 1 start-page: 175 issue: 1 year: 2018 ident: 753_CR137 publication-title: Commun. Biol. doi: 10.1038/s42003-018-0179-3 – volume: 168 year: 2020 ident: 753_CR54 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112520 – volume: 117 start-page: 678 year: 2018 ident: 753_CR122 publication-title: Biosensors Bioelectron. doi: 10.1016/j.bios.2018.06.062 – volume: 3 start-page: 255 year: 2014 ident: 753_CR1 publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev-cellbio-101512-122326 – volume: 16 start-page: 2004492 issue: 48 year: 2020 ident: 753_CR77 publication-title: Small doi: 10.1002/smll.202004492 – volume: 90 start-page: 6556 issue: 11 year: 2018 ident: 753_CR158 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b00189 – volume: 7 start-page: 6670 issue: 43 year: 2019 ident: 753_CR186 publication-title: J. Mater. Chem. B doi: 10.1039/C9TB01490J – volume: 64 start-page: 1650 issue: 7 year: 2017 ident: 753_CR83 publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2016.2601014 – volume: 63 start-page: 1633 issue: 10 year: 2017 ident: 753_CR109 publication-title: Clin. Chem. doi: 10.1373/clinchem.2016.271049 – volume: 14 start-page: 14528 issue: 11 year: 2020 ident: 753_CR120 publication-title: ACS Nano doi: 10.1021/acsnano.0c07581 – volume: 48 start-page: 11942 issue: 98 year: 2012 ident: 753_CR131 publication-title: Chem. Comm. doi: 10.1039/C2CC36111F – volume: 90 start-page: 14402 issue: 24 year: 2018 ident: 753_CR56 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b03959 – volume: 37 start-page: 310 issue: 3 year: 2019 ident: 753_CR221 publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2018.08.005 – volume: 582 start-page: 277 issue: 7811 year: 2020 ident: 753_CR201 publication-title: Nature doi: 10.1038/s41586-020-2279-8 – year: 2021 ident: 753_CR216 publication-title: Chin. Chem. Lett. doi: 10.1016/j.cclet.2021.09.058 – volume: 5 start-page: 29975 issue: 1 year: 2016 ident: 753_CR162 publication-title: J. Extracell. Vesicles doi: 10.3402/jev.v5.29975 – volume: 2 start-page: 80 issue: 1 year: 2021 ident: 753_CR26 publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.07 – volume: 140 start-page: 15904 issue: 46 year: 2018 ident: 753_CR183 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b09422 – volume: 86 start-page: 202 year: 2016 ident: 753_CR74 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2016.06.058 – volume: 111 start-page: 14888 issue: 41 year: 2014 ident: 753_CR72 publication-title: PNAS doi: 10.1073/pnas.1408301111 – volume: 8 start-page: 2102789 issue: 20 year: 2021 ident: 753_CR222 publication-title: Adv. Sci. doi: 10.1002/advs.202102789 – volume: 20 start-page: 2423 issue: 14 year: 2020 ident: 753_CR40 publication-title: Lab Chip doi: 10.1039/D0LC00431F – volume: 134 year: 2020 ident: 753_CR182 publication-title: Bioelectrochemistry doi: 10.1016/j.bioelechem.2020.107532 – volume: 4 start-page: 26048 issue: 1 year: 2015 ident: 753_CR125 publication-title: J. Extracell. Vesicles doi: 10.3402/jev.v4.26048 – volume: 11 start-page: 11041 issue: 11 year: 2017 ident: 753_CR129 publication-title: ACS Nano doi: 10.1021/acsnano.7b05083 – volume: 128 start-page: 10395 issue: 35 year: 2016 ident: 753_CR167 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201603007 – volume: 10 start-page: 1144 issue: 1 year: 2019 ident: 753_CR68 publication-title: Nat. Comm. doi: 10.1038/s41467-019-09030-2 – volume: 3 start-page: 1553 issue: 8 year: 2018 ident: 753_CR181 publication-title: ACS Sens. doi: 10.1021/acssensors.8b00365 – volume: 10 start-page: 1802 issue: 2 year: 2016 ident: 753_CR92 publication-title: ACS Nano doi: 10.1021/acsnano.5b07584 – volume: 20 start-page: 41 issue: 2 year: 2018 ident: 753_CR111 publication-title: AAPS J. doi: 10.1208/s12248-018-0201-1 – volume: 6 start-page: 2556 issue: 19 year: 2020 ident: 753_CR63 publication-title: Sci. Adv. doi: 10.1126/sciadv.aba2556 – volume: 14 start-page: 5435 issue: 5 year: 2020 ident: 753_CR220 publication-title: ACS Nano doi: 10.1021/acsnano.9b09119 – volume: 2 start-page: 20210003 issue: 4 year: 2021 ident: 753_CR73 publication-title: VIEW doi: 10.1002/VIW.20210003 – volume: 3 start-page: 2560 issue: 5 year: 2020 ident: 753_CR212 publication-title: ACS Appl. Bio Mater. doi: 10.1021/acsabm.9b00825 – volume: 2 start-page: 1 issue: 1 year: 2021 ident: 753_CR2 publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.09 – volume: 5 start-page: 487 issue: 2 year: 2018 ident: 753_CR94 publication-title: ACS Photonics doi: 10.1021/acsphotonics.7b00992 – volume: 9 issue: 787 year: 2021 ident: 753_CR33 publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2021.735711 – volume: 7 start-page: 569 issue: 4 year: 2017 ident: 753_CR13 publication-title: J. Parkinsons. Dis. doi: 10.3233/JPD-171176 – volume: 30 start-page: 1910335 issue: 17 year: 2020 ident: 753_CR31 publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201910335 – volume: 6 start-page: 8797 issue: 1 year: 2015 ident: 753_CR175 publication-title: Nat. Commun. doi: 10.1038/ncomms9797 – volume: 12 start-page: 494 issue: 1 year: 2018 ident: 753_CR51 publication-title: ACS Nano doi: 10.1021/acsnano.7b07060 – volume: 29 start-page: 700 issue: 3 year: 2018 ident: 753_CR219 publication-title: Ann. Oncol. doi: 10.1093/annonc/mdx765 – volume: 37 start-page: 730 issue: 7 year: 2019 ident: 753_CR195 publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2018.12.005 – volume: 92 start-page: 9877 issue: 14 year: 2020 ident: 753_CR22 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c01387 – volume: 15 start-page: 5631 issue: 3 year: 2021 ident: 753_CR159 publication-title: ACS Nano doi: 10.1021/acsnano.1c00782 – volume: 2 start-page: 1800021 issue: 9 year: 2018 ident: 753_CR24 publication-title: Small Methods doi: 10.1002/smtd.201800021 – volume: 32 start-page: 2509 issue: 10 year: 2016 ident: 753_CR150 publication-title: Langmuir doi: 10.1021/acs.langmuir.5b04550 – volume: 6 start-page: eaax3223 issue: 9 year: 2020 ident: 753_CR39 publication-title: Sci. Adv. doi: 10.1126/sciadv.aax3223 – volume: 8 start-page: 2000162 issue: 14 year: 2020 ident: 753_CR193 publication-title: Adv. Opt. Mater. doi: 10.1002/adom.202000162 – volume: 771 start-page: 31 year: 2013 ident: 753_CR44 publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2013.02.005 – volume: 12 start-page: 7577 issue: 14 year: 2020 ident: 753_CR110 publication-title: Nanoscale doi: 10.1039/D0NR00619J – volume: 2 start-page: 318 issue: 5 year: 2007 ident: 753_CR191 publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2007.99 – volume: 58 start-page: 4983 issue: 15 year: 2019 ident: 753_CR89 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/ange.201900092 – volume: 12 start-page: 671 issue: 1 year: 2018 ident: 753_CR168 publication-title: ACS Nano doi: 10.1021/acsnano.7b07782 – volume: 2 start-page: 104 issue: 2 year: 2021 ident: 753_CR10 publication-title: Extracell. Vesicles Circ. Nucleic Acids doi: 10.20517/evcna.2021.02 – volume: 16 start-page: 489 issue: 3 year: 2016 ident: 753_CR43 publication-title: Lab Chip doi: 10.1039/c5lc01117e – volume: 181 year: 2021 ident: 753_CR160 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2021.113155 – volume: 48 start-page: 850 issue: 3 year: 2019 ident: 753_CR189 publication-title: Chem. Soc. Rev. doi: 10.1039/C8CS00303C – volume: 161 year: 2020 ident: 753_CR126 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112222 – volume: 12 start-page: 1407 issue: 5 year: 2016 ident: 753_CR27 publication-title: Mol. Biosyst. doi: 10.1039/C6MB00082G – volume: 86 start-page: 11125 issue: 22 year: 2014 ident: 753_CR84 publication-title: Anal. Chem. doi: 10.1021/ac502082b – volume: 3 start-page: e1501645 issue: 3 year: 2017 ident: 753_CR64 publication-title: Sci. Adv. doi: 10.1126/sciadv.1501645 – volume: 59 start-page: 3131 issue: 8 year: 2020 ident: 753_CR149 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201915046 – volume: 145 start-page: 2795 issue: 7 year: 2020 ident: 753_CR38 publication-title: Analyst doi: 10.1039/C9AN02180A – volume: 37 start-page: 791 issue: 8 year: 2019 ident: 753_CR203 publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2019.04.005 – volume: 20 start-page: 954 issue: 8 year: 2014 ident: 753_CR205 publication-title: Nat. Med. doi: 10.1038/nm.3618 – volume: 4 start-page: 1900307 issue: 12 year: 2020 ident: 753_CR157 publication-title: Adv. Biosyst. doi: 10.1002/adbi.201900307 – volume: 46 start-page: 3945 issue: 13 year: 2017 ident: 753_CR42 publication-title: Chem. Soc. Rev. doi: 10.1039/C7CS00172J – volume: 12 start-page: 727 issue: 6 year: 2016 ident: 753_CR179 publication-title: Small doi: 10.1002/smll.201502365 – volume: 21 start-page: 4643 issue: 11 year: 2021 ident: 753_CR200 publication-title: Nano Lett. doi: 10.1021/acs.nanolett.1c00715 – volume: 14 start-page: 3773 issue: 19 year: 2014 ident: 753_CR49 publication-title: Lab Chip doi: 10.1039/C4LC00662C – volume: 41 start-page: 3297 issue: 8 year: 2012 ident: 753_CR178 publication-title: Chem. Soc. Rev. doi: 10.1039/C2CS15267C – volume: 123 year: 2020 ident: 753_CR184 publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2019.115767 – volume: 17 start-page: 2008155 issue: 14 year: 2021 ident: 753_CR52 publication-title: Small doi: 10.1002/smll.202008155 – volume: 1 start-page: 1432 issue: 12 year: 2016 ident: 753_CR132 publication-title: ACS Sens. doi: 10.1021/acssensors.6b00532 – volume: 13 start-page: 58 year: 2021 ident: 753_CR194 publication-title: Nano-Micro Lett. doi: 10.1007/s40820-020-00583-2 – volume: 56 start-page: 11916 issue: 39 year: 2017 ident: 753_CR88 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201703807 – volume: 184 start-page: 219 year: 2018 ident: 753_CR53 publication-title: Talanta doi: 10.1016/j.talanta.2018.02.083 – volume: 94 start-page: 400 year: 2017 ident: 753_CR108 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2017.03.036 – volume: 43 start-page: 2680 issue: 8 year: 2014 ident: 753_CR170 publication-title: Chem. Soc. Rev. doi: 10.1039/C3CS60353A – volume: 11 start-page: 59 year: 2019 ident: 753_CR185 publication-title: Nano-Micro Lett. doi: 10.1007/s40820-019-0285-x – volume: 111 start-page: 1310 issue: 4 year: 2014 ident: 753_CR139 publication-title: PNAS doi: 10.1073/pnas.1318602111 – volume: 58 start-page: 1612 issue: 6 year: 2019 ident: 753_CR91 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201811142 – volume: 136 start-page: 60 year: 2019 ident: 753_CR148 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2019.04.043 – volume: 12 start-page: 70 year: 2020 ident: 753_CR29 publication-title: Nano-Micro Lett. doi: 10.1007/s40820-020-0404-8 – volume: 27 start-page: 255 issue: 1 year: 2019 ident: 753_CR124 publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.03.003 – volume: 554 start-page: 249 issue: 7691 year: 2018 ident: 753_CR21 publication-title: Nature doi: 10.1038/nature25456 – volume: 10 start-page: 9053 year: 2018 ident: 753_CR37 publication-title: Nanoscale doi: 10.1039/C7NR09162A – volume: 123 year: 2020 ident: 753_CR19 publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2019.115773 – volume: 30 start-page: 29 issue: 1 year: 2009 ident: 753_CR144 publication-title: Electrophoresis doi: 10.1002/elps.200800425 – volume: 420 start-page: 20 issue: 1 year: 2012 ident: 753_CR153 publication-title: Anal. Biochem. doi: 10.1016/j.ab.2011.09.004 – volume: 12 start-page: 4455 issue: 21 year: 2012 ident: 753_CR156 publication-title: Lab Chip doi: 10.1039/C2LC40727B – volume: 15 start-page: 1656 issue: 7 year: 2015 ident: 753_CR215 publication-title: Lab Chip doi: 10.1039/C5LC00036J – volume: 117 start-page: 22736 issue: 37 year: 2020 ident: 753_CR188 publication-title: PNAS doi: 10.1073/pnas.2011660117 – volume: 9 start-page: l3226 issue: 391 year: 2017 ident: 753_CR102 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aal3226 – volume: 154 year: 2020 ident: 753_CR50 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112056 – volume: 34 start-page: 474 issue: 4 year: 2015 ident: 753_CR28 publication-title: Mass Spectrom. Rev. doi: 10.1002/mas.21420 |
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Extracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies.
Multiplexing in EV... Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of... HighlightsExtracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies.Multiplexing in EV... Extracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies.Multiplexing in EV biomarker... Abstract Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the... |
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| SubjectTerms | Biomarker Biomarkers Body fluids Egress Engineering Exosomes Extracellular vesicles Liquid biopsy Multiplexed profiling Multiplexing Nanobiomedicine Nanoparticles Nanoscale Science and Technology Nanotechnology Nanotechnology and Microengineering Nucleic acids Platforms Point-of-care Proteins Review Vesicles |
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| Title | Multiplexed Profiling of Extracellular Vesicles for Biomarker Development |
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