Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis

Background Drug resistance in tuberculosis (TB) poses a major ongoing challenge to public health. The recent inclusion of bedaquiline into TB drug regimens has improved treatment outcomes, but this advance is threatened by the emergence of strains of Mycobacterium tuberculosis ( Mtb ) resistant to b...

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Bibliographic Details
Published in:	Genome medicine Vol. 16; no. 1; pp. 34 - 15
Main Authors:	Nimmo, Camus, Ortiz, Arturo Torres, Tan, Cedric C. S., Pang, Juanita, Acman, Mislav, Millard, James, Padayatchi, Nesri, Grant, Alison D., O’Donnell, Max, Pym, Alex, Brynildsrud, Ola B., Eldholm, Vegard, Grandjean, Louis, Didelot, Xavier, Balloux, François, van Dorp, Lucy
Format:	Journal Article
Language:	English
Published:	London BioMed Central 19.02.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	AMR Antibiotics Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Archives & records Bedaquiline Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Research Clinical outcomes Clinical trials Clofazimine Cross-resistance Datasets Diarylquinolines Disease susceptibility Drug resistance Drug resistance in microorganisms Epistasis Genes Genomes Genomics Human Genetics Humans Medicine/Public Health Metabolomics Metadata Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Phylogenetics Phylogeny Public health Systems Biology Tuberculosis Tuberculosis - drug therapy South Africa Phylogenetics Tuberculosis Drug resistance AMR Bedaquiline
ISSN:	1756-994X, 1756-994X
Online Access:	Get full text
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