Adverse events in an integrated home-based treatment program for MDR-TB and HIV in KwaZulu-Natal, South Africa

Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB pat...

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Published in:Journal of acquired immune deficiency syndromes (1999) Vol. 62; no. 4; p. 436
Main Authors: Brust, James C M, Shah, N Sarita, van der Merwe, Theo L, Bamber, Sheila, Ning, Yuming, Heo, Moonseong, Moll, Anthony P, Loveday, Marian, Lalloo, Umesh G, Friedland, Gerald H, Gandhi, Neel R
Format: Journal Article
Language:English
Published: United States 01.04.2013
Subjects:
Antitubercular Agents - adverse effects
Antitubercular Agents - therapeutic use
HIV Infections - complications
HIV Infections - drug therapy
Home Care Services
Humans
South Africa
Tuberculosis, Multidrug-Resistant - complications
Tuberculosis, Multidrug-Resistant - drug therapy
South Africa
ISSN:1944-7884, 1944-7884
Online Access:Get more information
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Summary:Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a home-based care setting.
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ISSN:1944-7884
1944-7884
DOI:10.1097/QAI.0b013e31828175ed