Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus

In recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on the metabolic phenotype of the host are often considered to be mediated by short-chain fatty acids (SCFAs), mainl...

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Vydané v:The Canadian journal of infectious diseases & medical microbiology Ročník 2021; s. 1 - 13
Hlavní autori: Tang, Ruiqi, Li, Lanjuan
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Egypt Hindawi 04.01.2021
John Wiley & Sons, Inc
Wiley
Predmet:
Acetates
Acetic acid
Adipocytes
Adipose tissue
Bacteria
Binding sites
Carbohydrates
Care and treatment
Deoxyribonucleic acid
Dextrose
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes therapy
Dietary fiber
DNA
Energy
Energy balance
Esters
Fatty acids
Fermentation
Glucose
Health aspects
Homeostasis
Hormones
Infectious diseases
Inflammation
Insulin resistance
Intestinal microflora
Intestine
Lipids
Liver
Metabolic regulation
Metabolism
Metabolites
Methods
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Modulation
Muscles
Musculoskeletal system
Nervous system
Organs
Overweight
Pancreas
Pathogenesis
Peptides
Phenotypes
Physiological aspects
Physiology
Propionic acid
Review
Skeletal muscle
Type 2 diabetes
China
ISSN:1712-9532, 1918-1493
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Shrnutí:In recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on the metabolic phenotype of the host are often considered to be mediated by short-chain fatty acids (SCFAs), mainly acetate, butyrate, and propionate, the small-molecule metabolites derived from microbial fermentation of indigestible carbohydrates. SCFAs not only have an essential role in intestinal health but might also enter the systemic circulation as signaling molecules affecting the host’s metabolism. In this review, we summarize the effects of SCFAs on glucose homeostasis and energy homeostasis and the mechanism through which SCFAs regulate the function of metabolically active organs (brain, liver, adipose tissue, skeletal muscle, and pancreas) and discuss the potential role of modulation of SCFAs as a therapeutic method for T2DM.
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Academic Editor: Meng-Hao Huang
ISSN:1712-9532
1918-1493
DOI:10.1155/2021/6632266