Anopheles metabolic proteins in malaria transmission, prevention and control: a review

The increasing resistance to currently available insecticides in the malaria vector, Anopheles mosquitoes, hampers their use as an effective vector control strategy for the prevention of malaria transmission. Therefore, there is need for new insecticides and/or alternative vector control strategies,...

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Vydáno v:Parasites & vectors Ročník 13; číslo 1; s. 465
Hlavní autoři: Adedeji, Eunice Oluwatobiloba, Ogunlana, Olubanke Olujoke, Fatumo, Segun, Beder, Thomas, Ajamma, Yvonne, Koenig, Rainer, Adebiyi, Ezekiel
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 10.09.2020
Springer Nature B.V
BMC
Témata:
Acetylcholinesterase
Animals
Anopheles
Anopheles - drug effects
Anopheles - genetics
Anopheles - metabolism
Anopheles - parasitology
Aquatic insects
Biomedical and Life Sciences
Biomedicine
blood
Control
Defence mechanisms
digestion
Disease transmission
Entomology
Enzymes
Human diseases
Humans
Immune response
Immunity
Infectious Diseases
Insect Proteins - genetics
Insect Proteins - metabolism
Insecticide
Insecticide Resistance
Insecticides
Insecticides - pharmacology
Insects
Malaria
Malaria - parasitology
Malaria - prevention & control
Malaria - transmission
Metabolism
Modulators
Mosquito Control
mosquito vectors
Mosquito Vectors - drug effects
Mosquito Vectors - genetics
Mosquito Vectors - metabolism
Mosquito Vectors - parasitology
Mosquitoes
Nervous system
nontarget organisms
Parasites
Parasitology
Pesticide resistance
Plasmodium
Plasmodium - physiology
Population
Prevention
Proteins
Review
Specificity
Sterilants
Synergists
Target recognition
Toxicity
Tropical Medicine
Vector control
Vector-borne diseases
Veterinary Medicine/Veterinary Science
Virology
Yields
Immune response
Insecticide
Insecticide resistance
Acetylcholinesterase
Vector control
Plasmodium
ISSN:1756-3305, 1756-3305
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Shrnutí:The increasing resistance to currently available insecticides in the malaria vector, Anopheles mosquitoes, hampers their use as an effective vector control strategy for the prevention of malaria transmission. Therefore, there is need for new insecticides and/or alternative vector control strategies, the development of which relies on the identification of possible targets in Anopheles . Some known and promising targets for the prevention or control of malaria transmission exist among Anopheles metabolic proteins. This review aims to elucidate the current and potential contribution of Anopheles metabolic proteins to malaria transmission and control. Highlighted are the roles of metabolic proteins as insecticide targets, in blood digestion and immune response as well as their contribution to insecticide resistance and Plasmodium parasite development. Furthermore, strategies by which these metabolic proteins can be utilized for vector control are described. Inhibitors of Anopheles metabolic proteins that are designed based on target specificity can yield insecticides with no significant toxicity to non-target species. These metabolic modulators combined with each other or with synergists, sterilants, and transmission-blocking agents in a single product, can yield potent malaria intervention strategies. These combinations can provide multiple means of controlling the vector. Also, they can help to slow down the development of insecticide resistance. Moreover, some metabolic proteins can be modulated for mosquito population replacement or suppression strategies, which will significantly help to curb malaria transmission.
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ISSN:1756-3305
1756-3305
DOI:10.1186/s13071-020-04342-5