Role of the intestinal microbiome and microbial-derived metabolites in immune checkpoint blockade immunotherapy of cancer

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune inhibitory pathways. Administration of ICIs augments T cell-mediated immune responses against tumor, resulting in improved overall survival in cancer patients. It has emerged that the intestinal microbiome can modulate r...

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Bibliographic Details
Published in:	Genome medicine Vol. 13; no. 1; pp. 107 - 11
Main Authors:	Hayase, Eiko, Jenq, Robert R.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 23.06.2021 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Anti-Bacterial Agents - pharmacology Antibiotics Antibodies Antigen (tumor-associated) Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use B cells Bacteria Bioinformatics Biomarkers Biomedical and Life Sciences Biomedicine Cancer Cancer immunotherapy Cancer Research Cancer therapies Care and treatment Chemotherapy Colitis Colitis - etiology Cytotoxicity Development and progression Drug therapy Dysbiosis - etiology Epitopes Fecal microflora Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - immunology Gene expression Host Microbial Interactions - drug effects Host Microbial Interactions - immunology Human Genetics Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - adverse effects Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immune response Immune response (cell-mediated) Immune system Immunomodulation Immunotherapy Inflammatory bowel disease Intestinal microbiome Intestine Lymphocytes Lymphocytes T Medical research Medicine/Public Health Melanoma Metabolites Metabolome - drug effects Metabolomics Metabolomics - methods Microbiomes Microbiota Microbiota (Symbiotic organisms) Models, Biological Monoclonal antibodies Neoplasms - complications Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Obesity Oncology, Experimental Oral administration Patients Review Systems Biology T cells Translating the microbiome in health and disease Transplantation Tumor antigens Tumor microenvironment Tumors Metabolites Intestinal microbiome Immune checkpoint inhibitors
ISSN:	1756-994X, 1756-994X
Online Access:	Get full text
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