A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer’s Disease

Alzheimer’s Disease (AD) is characterized by progressive neurodegeneration and cognitive impairment. Synaptic dysfunction is an established early symptom, which correlates strongly with cognitive decline, and is hypothesised to mediate the diverse neuronal network abnormalities observed in AD. Howev...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 17; no. 6; p. e1009115
Main Authors:	Ness, Natalie, Schultz, Simon R.
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 16.06.2021 Public Library of Science (PLoS)
Subjects:	Abnormalities Alzheimer's disease Animal models Biology and Life Sciences Cognitive ability Competition Computational grids Computational neuroscience Development and progression Feedback Firing rate Health aspects Impairment Medicine and Health Sciences Memory Neurodegeneration Neurodegenerative diseases Presenilin 1 Pyramidal cells Representations Research and Analysis Methods Simulation Stability Synapses Transformation Transformations (mathematics) United Kingdom
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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