100 years of Bacillus Calmette-Guérin immunotherapy: from cattle to COVID-19

Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence in...

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Vydané v:Nature reviews. Urology Ročník 18; číslo 10; s. 611 - 622
Hlavní autori: Lobo, Niyati, Brooks, Nathan A, Zlotta, Alexandre R, Cirillo, Jeffrey D, Boorjian, Stephen, Black, Peter C, Meeks, Joshua J, Bivalacqua, Trinity J, Gontero, Paolo, Steinberg, Gary D, McConkey, David, Babjuk, Marko, Alfred Witjes, J, Kamat, Ashish M
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Nature Publishing Group 01.10.2021
Predmet:
Adjuvants, Immunologic - history
Animals
BCG Vaccine - history
Bladder cancer
Cattle
Coronaviruses
COVID-19 - prevention & control
COVID-19 Vaccines
History, 19th Century
History, 20th Century
Humans
Hypotheses
Immunotherapy
Immunotherapy - history
Infant
Pandemics
Tuberculosis
ISSN:1759-4812, 1759-4820, 1759-4820
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Shrnutí:Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence indicates that BCG offers protection against various non-mycobacterial and viral infections. The non-specific effects of BCG occur via the induction of trained immunity and form the basis for the hypothesis that BCG vaccination could be used to protect against the severity of coronavirus disease 2019 (COVID-19). This Perspective article highlights key milestones in the 100-year history of BCG and projects its potential role in the COVID-19 pandemic.
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ISSN:1759-4812
1759-4820
1759-4820
DOI:10.1038/s41585-021-00481-1