100 years of Bacillus Calmette-Guérin immunotherapy: from cattle to COVID-19

Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence in...

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Vydáno v:Nature reviews. Urology Ročník 18; číslo 10; s. 611 - 622
Hlavní autoři: Lobo, Niyati, Brooks, Nathan A, Zlotta, Alexandre R, Cirillo, Jeffrey D, Boorjian, Stephen, Black, Peter C, Meeks, Joshua J, Bivalacqua, Trinity J, Gontero, Paolo, Steinberg, Gary D, McConkey, David, Babjuk, Marko, Alfred Witjes, J, Kamat, Ashish M
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.10.2021
Témata:
Adjuvants, Immunologic - history
Animals
BCG Vaccine - history
Bladder cancer
Cattle
Coronaviruses
COVID-19 - prevention & control
COVID-19 Vaccines
History, 19th Century
History, 20th Century
Humans
Hypotheses
Immunotherapy
Immunotherapy - history
Infant
Pandemics
Tuberculosis
ISSN:1759-4812, 1759-4820, 1759-4820
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Abstract Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence indicates that BCG offers protection against various non-mycobacterial and viral infections. The non-specific effects of BCG occur via the induction of trained immunity and form the basis for the hypothesis that BCG vaccination could be used to protect against the severity of coronavirus disease 2019 (COVID-19). This Perspective article highlights key milestones in the 100-year history of BCG and projects its potential role in the COVID-19 pandemic.
AbstractList Bacillus Calmette–Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence indicates that BCG offers protection against various non-mycobacterial and viral infections. The non-specific effects of BCG occur via the induction of trained immunity and form the basis for the hypothesis that BCG vaccination could be used to protect against the severity of coronavirus disease 2019 (COVID-19). This Perspective article highlights key milestones in the 100-year history of BCG and projects its potential role in the COVID-19 pandemic.Bacillus Calmette–Guérin (BCG) has been used to prevent tuberculosis for a century and is also a standard approach for the treatment of non-muscle-invasive bladder cancer. However, BCG also has a plethora of non-specific effects that occur via the induction of trained immunity and have raised the hypothesis that BCG vaccination could be used to protect against coronavirus disease 2019 (COVID-19). In this Perspective, the authors describe the history of BCG, discuss the mechanisms of its effects, and consider its potential role during the COVID-19 pandemic.
Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence indicates that BCG offers protection against various non-mycobacterial and viral infections. The non-specific effects of BCG occur via the induction of trained immunity and form the basis for the hypothesis that BCG vaccination could be used to protect against the severity of coronavirus disease 2019 (COVID-19). This Perspective article highlights key milestones in the 100-year history of BCG and projects its potential role in the COVID-19 pandemic.
Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence indicates that BCG offers protection against various non-mycobacterial and viral infections. The non-specific effects of BCG occur via the induction of trained immunity and form the basis for the hypothesis that BCG vaccination could be used to protect against the severity of coronavirus disease 2019 (COVID-19). This Perspective article highlights key milestones in the 100-year history of BCG and projects its potential role in the COVID-19 pandemic.Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence indicates that BCG offers protection against various non-mycobacterial and viral infections. The non-specific effects of BCG occur via the induction of trained immunity and form the basis for the hypothesis that BCG vaccination could be used to protect against the severity of coronavirus disease 2019 (COVID-19). This Perspective article highlights key milestones in the 100-year history of BCG and projects its potential role in the COVID-19 pandemic.
Author Zlotta, Alexandre R
Brooks, Nathan A
Meeks, Joshua J
Cirillo, Jeffrey D
Black, Peter C
Steinberg, Gary D
Kamat, Ashish M
Alfred Witjes, J
Babjuk, Marko
Lobo, Niyati
Bivalacqua, Trinity J
Gontero, Paolo
Boorjian, Stephen
McConkey, David
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  organization: Department of Urology, MD Anderson Cancer Center, Houston, TX, USA
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  organization: Department of Urology, MD Anderson Cancer Center, Houston, TX, USA
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  organization: Department of Surgical Oncology, Division of Urology, Princess Margaret Cancer Centre, University of Toronto and University Health Network, Toronto, ON, Canada
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  surname: Cirillo
  fullname: Cirillo, Jeffrey D
  organization: Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX, USA
– sequence: 5
  givenname: Stephen
  surname: Boorjian
  fullname: Boorjian, Stephen
  organization: Department of Urology, Mayo Clinic, Rochester, MN, USA
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  organization: Vancouver Prostate Centre, Vancouver, BC, Canada
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  organization: Northwestern University School of Medicine, Chicago, IL, USA
– sequence: 8
  givenname: Trinity J
  surname: Bivalacqua
  fullname: Bivalacqua, Trinity J
  organization: The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
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  fullname: Gontero, Paolo
  organization: Division of Urology, Molinette Hospital, University of Torino School of Medicine, Torino, Italy
– sequence: 10
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  surname: Steinberg
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  organization: Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
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  orcidid: 0000-0003-3546-9928
  surname: Kamat
  fullname: Kamat, Ashish M
  email: akamat@mdanderson.org
  organization: Department of Urology, MD Anderson Cancer Center, Houston, TX, USA. akamat@mdanderson.org
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34131332$$D View this record in MEDLINE/PubMed
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Snippet Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an...
Bacillus Calmette–Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an...
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SubjectTerms Adjuvants, Immunologic - history
Animals
BCG Vaccine - history
Bladder cancer
Cattle
Coronaviruses
COVID-19 - prevention & control
COVID-19 Vaccines
History, 19th Century
History, 20th Century
Humans
Hypotheses
Immunotherapy
Immunotherapy - history
Infant
Pandemics
Tuberculosis
Title 100 years of Bacillus Calmette-Guérin immunotherapy: from cattle to COVID-19
URI https://www.ncbi.nlm.nih.gov/pubmed/34131332
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