Grape Polyphenols Prevent Fructose-Induced Oxidative Stress and Insulin Resistance in First-Degree Relatives of Type 2 Diabetic Patients

To assess the clinical efficacy of nutritional amounts of grape polyphenols (PPs) in counteracting the metabolic alterations of high-fructose diet, including oxidative stress and insulin resistance (IR), in healthy volunteers with high metabolic risk. Thirty-eight healthy overweight/obese first-degr...

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Bibliographic Details
Published in:	Diabetes care Vol. 36; no. 6; pp. 1454 - 1461
Main Authors:	Hokayem, Marie, Blond, Emilie, Vidal, Hubert, Lambert, Karen, Meugnier, Emmanuelle, Feillet-Coudray, Christine, Coudray, Charles, Pesenti, Sandra, Luyton, Cedric, Lambert-Porcheron, Stéphanie, Sauvinet, Valerie, Fedou, Christine, Brun, Jean-Frédéric, Rieusset, Jennifer, Bisbal, Catherine, Sultan, Ariane, Mercier, Jacques, Goudable, Joelle, Dupuy, Anne-Marie, Cristol, Jean-Paul, Laville, Martine, Avignon, Antoine
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01.06.2013
Subjects:	Adult Aged Biological and medical sciences Care and treatment Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Diabetics Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fructose - adverse effects Humans Insulin Insulin resistance Insulin Resistance - physiology Life Sciences Male Medical sciences Metabolic diseases Metabolic disorders Middle Aged Miscellaneous Original Research Oxidative stress Oxidative Stress - drug effects Polyphenols Polyphenols - chemistry Polyphenols - therapeutic use Public health. Hygiene Public health. Hygiene-occupational medicine Vitis - chemistry France Endocrinopathy Type 2 diabetes Human Oxidative stress Pancreatic hormone Nutrition Patient Metabolic diseases Insulin Fructose Prevention Target tissue resistance Polyphenol Grape Phenols Insulin resistance Inheritance(genetics) Endocrinology SKELETAL-MUSCLE DIET WINE CONSUMPTION RATS HUMANS GENE-EXPRESSION MITOCHONDRIAL DYSFUNCTION MICE METABOLIC DISEASES HEPATIC STEATOSIS
ISSN:	0149-5992, 1935-5548, 1935-5548, 0149-5992
Online Access:	Get full text
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