Clinical outcomes in patients with atrial fibrillation and frailty: insights from the ENGAGE AF-TIMI 48 trial

Background Atrial fibrillation (AF) is common in older people with frailty and is associated with an increased risk of stroke and systemic embolism. Whilst oral anticoagulation is associated with a reduction in this risk, there is a lack of data on the safety and efficacy of direct oral anticoagulan...

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Bibliographic Details
Published in:	BMC medicine Vol. 18; no. 1; pp. 401 - 12
Main Authors:	Wilkinson, Chris, Wu, Jianhua, Searle, Samuel D., Todd, Oliver, Hall, Marlous, Kunadian, Vijay, Clegg, Andrew, Rockwood, Kenneth, Gale, Chris P.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 24.12.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adult Age Aged Aged, 80 and over Anticoagulants Anticoagulants - administration & dosage Anticoagulants - adverse effects Anticoagulation Atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - diagnosis Atrial Fibrillation - drug therapy Biomedicine Bleeding Blood Coagulation - drug effects Cardiac arrhythmia Cerebral infarction Clinical outcomes Clinical trial Clinical trials Creatinine Dosage and administration Double-Blind Method Drug Administration Schedule Drug dosages Drug therapy Embolism Embolisms Factor Xa Inhibitors - therapeutic use Female Fibrillation Follow-Up Studies Frail elderly Frailty Frailty - complications Frailty - diagnosis Frailty - drug therapy Health risks Hemorrhage - chemically induced Humans Male Medicine Medicine & Public Health Middle Aged Mortality Myocardial infarction Myocardial Infarction - complications Myocardial Infarction - diagnosis Myocardial Infarction - drug therapy Older people Patient outcomes Patients Population studies Prognosis Pyridines - administration & dosage Pyridines - adverse effects Research Article Risk Risk factors Safety Stroke Thiazoles - administration & dosage Thiazoles - adverse effects Thrombolysis Thrombolytic drugs Treatment Outcome Variables Warfarin Warfarin - therapeutic use United Kingdom Frailty Clinical trial Stroke Anticoagulation Atrial fibrillation
ISSN:	1741-7015, 1741-7015
Online Access:	Get full text
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